[8-14C]-uric acid | 92334-71-9

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪类
• 英文名称: [8-14C]-uric acid
• 英文别名: [¹⁴C]-uric acid；7,9-dihydro-3H-purine-2,6,8-trione
• CAS: 92334-71-9
• 化学式: C₅H₄N₄O₃
• 分子量: 170.101
• InChiKey: LEHOTFFKMJEONL-DOMIDYPGSA-N

反应信息

• 作为反应物：
  描述：

  [8-14C]-uric acid 在 Bacillus fastidiosus uricase 、 catalase 作用下， 生成 DL-2-(14)C-allantoin 、 DL-[H2N(14)CO]allantoin
  参考文献：
  名称：

  Purine Nucleotide Catabolism in Rat Liver. Certain Preliminary Aspects of Uricase Reaction

  摘要：

  We investigated the mechanism of action of uricase, which oxidizes uric acid to allantoin, in the rat. Allantoin may decompose chemically to urea and hydantoin, containing the carbons in positions 2 and 8 of the purine ring, respectively. These carbons are derived by formylation, catalyzed by formyltransferase, in two reactions of de novo synthesis. Since uric acid and allantoin are represented in equivalent amounts in the liver, we expected to find identical incorporation of radioactivity in C2 and C8 of both compounds after administration of 14C-formate. In the case of 14C-allantoin, this was true, but not for 14C-uric acid extracted from rat liver. We interpret these results through a series of experiments and considerations.

  DOI：

  10.1080/15257770902865381