1,2-O-dioleyl-3-O-[2-[(12-crown-4-)-methoxy]ethyl]-sn-glycerol | 1134802-75-7

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 甘油脂
• 英文名称: 1,2-O-dioleyl-3-O-[2-[(12-crown-4-)-methoxy]ethyl]-sn-glycerol
• CAS: 1134802-75-7
• 化学式: C₅₀H₉₂O₁₀
• 分子量: 853.274
• InChiKey: VJOSRPDSJTZTFO-XDLWQMJLSA-N

物化性质

• 沸点：
  827.9±65.0 °C(predicted)
• 密度：
  0.967±0.06 g/cm3(Temp: 20 °C; Press: 760 Torr)(predicted)

反应信息

• 作为反应物：
  描述：

  1,2-O-dioleyl-3-O-[2-[(12-crown-4-)-methoxy]ethyl]-sn-glycerol 、 manganese(ll) chloride 以 水 为溶剂， 生成 1,2-O-dioleyl-3-O-[2-[(12-crown-4-)-methoxy]ethyl]-sn-glycerol*manganese dichloride
  参考文献：
  名称：

  12-Crown-4-based amphipathic lipid and corresponding metal cation complexes for gene therapy applications: FT-IR characterization and surface charge determination

  摘要：

  The new lipid 1,2-O-dioleyl-3-O-{2-[(12-crown-4)-methoxy]-ethyl}-sn-glycerol, 12C4L, has been synthesized. This molecule can coordinate different cations that should make the corresponding liposome a good candidate as vector of genetic material for possible applications in gene therapy. An important feature of the molecule is the possibility to modulate the net surface charge of their complexes with metal cations, which is important to provide efficient DNA transfections. The molecule and its complexes with some metal cations (Mg2+, Ca2+, Mn2+) have been characterized by FT-IR spectroscopy and band attributions confirmed by Density Functional Theory calculations. The net surface charge has been determined by Z potential determinations. (C) 2008 Elsevier B.V. All rights reserved.

  DOI：

  10.1016/j.molstruc.2008.09.030