3-Chloro-6-(4-chloro-phenyl)-thieno[2,3-b]pyrazine | 909301-53-7

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 噻吩并吡啶类
• 英文名称: 3-Chloro-6-(4-chloro-phenyl)-thieno[2,3-b]pyrazine
• CAS: 909301-53-7
• 化学式: C₁₂H₆Cl₂N₂S
• 分子量: 281.165
• InChiKey: BEJZTDIVMUJETN-UHFFFAOYSA-N

反应信息

• 作为反应物：
  描述：

  3-Chloro-6-(4-chloro-phenyl)-thieno[2,3-b]pyrazine 在 aluminium hydride 、 (1,4-bis(diphenylphosphino)butane)palladium chloride 、 cesium fluoride 作用下， 以 四氢呋喃 、 乙二醇二甲醚 为溶剂， 反应 13.0h， 生成 6-(4-Chloro-phenyl)-3-[3-methoxy-4-(2-pyrrolidin-1-yl-ethoxy)-phenyl]-thieno[2,3-b]pyrazine
  参考文献：
  名称：

  The discovery and optimization of pyrimidinone-containing MCH R1 antagonists

  摘要：

  Optimization of a series of constrained melanin-concentrating hormone receptor 1 (MCH RI) antagonists has provided compounds with potent and selective MCH R1 activity. Details of the optimization process are provided and the use of one of the compounds in an animal model of diet-induced obesity is presented. (c) 2006 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2006.07.008
• 作为产物：
  描述：

  6-(4-Chloro-phenyl)-thieno[2,3-b]pyrazine 4-oxide 在 三氯氧磷 作用下， 反应 1.0h， 生成 3-Chloro-6-(4-chloro-phenyl)-thieno[2,3-b]pyrazine
  参考文献：
  名称：

  The discovery and optimization of pyrimidinone-containing MCH R1 antagonists

  摘要：

  Optimization of a series of constrained melanin-concentrating hormone receptor 1 (MCH RI) antagonists has provided compounds with potent and selective MCH R1 activity. Details of the optimization process are provided and the use of one of the compounds in an animal model of diet-induced obesity is presented. (c) 2006 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2006.07.008