[2-(11)C]5-FU | 1041333-31-6

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪类
• 英文名称: [2-(11)C]5-FU
• CAS: 1041333-31-6
• 化学式: C₄H₃FN₂O₂
• 分子量: 129.067
• InChiKey: GHASVSINZRGABV-NUTRPMROSA-N

反应信息

• 作为产物：
  描述：

  [2-(11)C]N-benzoyl-5-FU 在 氨 作用下， 以 甲醇 为溶剂， 反应 0.02h， 生成 [2-(11)C]5-FU
  参考文献：
  名称：

  New [11C]Phosgene Based Synthesis of [11C]Pyrimidines for Positron Emission Tomography

  摘要：

  Thymine, 5-FU, and uracil were successfully synthesized through a procedure involving a cyclocondensation of triphosgene with newly developed alpha-substituted beta-aminoacrylamides intermediates (1a, X = Me; 1b, X = F; 1c, X = H). The radioligands [2-C-11]thymine and [2-C-11]5-fluorouracil were synthesized in high radiochemical yields in 16-17 minutes from the end of bombardment by applying the cyclocondensation method with [C-11]COCl2,

  DOI：

  10.3987/com-08-s(f)116