6-tert-butylchroman-8-carbaldehyde | 1165739-46-7

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并吡喃
• 英文名称: 6-tert-butylchroman-8-carbaldehyde
• CAS: 1165739-46-7
• 化学式: C₁₄H₁₈O₂
• 分子量: 218.296
• InChiKey: DVGUBYIWGWLFCY-UHFFFAOYSA-N

反应信息

• 作为反应物：
  描述：

  丙二酸 、 6-tert-butylchroman-8-carbaldehyde 在 哌啶 、 吡啶 作用下， 反应 2.0h， 以86%的产率得到(E)-3-(6-tert-butylchroman-8-yl)acrylic acid
  参考文献：
  名称：

  Design, synthesis, and biological evaluation of novel diarylalkyl amides as TRPV1 antagonists

  摘要：

  We have developed a new class of diarylalkyl amides as novel TRPV1 antagonists. They exhibited potent Ca-45(2+) uptake inhibitions in rat DRG neuron. In particular, the amide 59 was identified as a potent antagonist with IC50 of 57 nM. The synthesis and structure-activity relationship of the diarylalkyl amides are also described. (C) 2009 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmc.2009.04.010
• 作为产物：
  描述：

  、 N,N-二甲基甲酰胺 在 叔丁基锂 作用下， 以 四氢呋喃 、 正己烷 为溶剂， 反应 0.5h， 生成 6-tert-butylchroman-8-carbaldehyde
  参考文献：
  名称：

  Design, synthesis, and biological evaluation of novel diarylalkyl amides as TRPV1 antagonists

  摘要：

  We have developed a new class of diarylalkyl amides as novel TRPV1 antagonists. They exhibited potent Ca-45(2+) uptake inhibitions in rat DRG neuron. In particular, the amide 59 was identified as a potent antagonist with IC50 of 57 nM. The synthesis and structure-activity relationship of the diarylalkyl amides are also described. (C) 2009 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmc.2009.04.010