| 1142204-15-6

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 大环内酯类和类似物
• CAS: 1142204-15-6
• 化学式: C₂₂H₃₄O₄
• 分子量: 362.51
• InChiKey: MTWAVIQCPSMKLF-COTNDKPBSA-N

反应信息

• 作为反应物：
  描述：

  在 lithium hydroxide 作用下， 以 四氢呋喃 、 水 为溶剂， 反应 4.0h， 以100%的产率得到4-(R)-F(3t)-neuroprostane
  参考文献：
  名称：

  Total synthesis of 4-F3t-neuroprostane and its 4-epimer

  摘要：

  The first synthesis of 4-F-3t-Neuroprostane 1a and its 4-epimer is described. This molecule presents an important contribution to the study of neuronal oxidative stress in DHA-omega 3 depleted brain. The key step involves the introduction of two unsaturated side chains into the chiral polyfunctional cyclopentane 4 via E selective HWE reaction and Z selective Wittig olefination for alpha and omega chains, respectively. (C) 2009 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2009.01.075
• 作为产物：
  描述：

  在 四丁基氟化铵 作用下， 以 四氢呋喃 为溶剂， 反应 4.0h， 生成 、 (5R)-5-[(E)-2-[(1S,2R,3R,5S)-3,5-dihydroxy-2-[(2Z,5Z)-undeca-2,5-dienyl]cyclopentyl]ethenyl]oxolan-2-one
  参考文献：
  名称：

  Total synthesis of 4-F3t-neuroprostane and its 4-epimer

  摘要：

  The first synthesis of 4-F-3t-Neuroprostane 1a and its 4-epimer is described. This molecule presents an important contribution to the study of neuronal oxidative stress in DHA-omega 3 depleted brain. The key step involves the introduction of two unsaturated side chains into the chiral polyfunctional cyclopentane 4 via E selective HWE reaction and Z selective Wittig olefination for alpha and omega chains, respectively. (C) 2009 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2009.01.075