| 1018855-99-6

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• CAS: 1018855-99-6
• 化学式: C₂₆H₂₇N₃O₃
• 分子量: 429.519
• InChiKey: HFWIAPXHDUWZGX-UHFFFAOYSA-N

反应信息

• 作为反应物：
  描述：

  、 在 4-二甲氨基吡啶 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 生成
  参考文献：
  名称：

  Novel echinocandin antifungals. Part 1: Novel side-chain analogs of the natural product FR901379

  摘要：

  A series of novel acylated analogs of the novel water-soluble echinocandin FR901379 have been prepared and evaluated for antifungal and hemolytic activity. A relationship between antifungal activity and lipophilicity of the acyl side chain, expressed as ClogP was demonstrated, and an analog (3c) with 5.5- to 8-fold superior in vivo activity relative to the previously disclosed 4-(n-octyloxy) benzoyl side chain analog, FR131535 obtained. (c) 2008 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2007.12.062