[(2S)-7-(9H-fluoren-9-ylmethoxycarbonylamino)-2-(4-hydroxybenzyl)-3-oxo-1,2,3,5-tetrahydrobenzo[1,4]diazepin-4-yl]acetic acid | 669772-24-1

• 分子结构分类: 有机化合物 - 苯类化合物 - 芴
• 英文名称: [(2S)-7-(9H-fluoren-9-ylmethoxycarbonylamino)-2-(4-hydroxybenzyl)-3-oxo-1,2,3,5-tetrahydrobenzo[1,4]diazepin-4-yl]acetic acid
• CAS: 669772-24-1
• 化学式: C₃₃H₂₉N₃O₆
• 分子量: 563.61
• InChiKey: APEBVPIBKMEVNA-PMERELPUSA-N

反应信息

• 作为反应物：
  描述：

  Fmoc-L-缬氨酸 、 Fmoc-L-丙氨酸 、 Fmoc-L-天冬氨酸 beta-叔丁酯 、 [(2S)-7-(9H-fluoren-9-ylmethoxycarbonylamino)-2-(4-hydroxybenzyl)-3-oxo-1,2,3,5-tetrahydrobenzo[1,4]diazepin-4-yl]acetic acid 、 alkaline earth salt of/the/ methylsulfuric acid 以39.1%的产率得到(3S)-3-amino-4-[[(2S)-1-[[(2S)-1-[[(2S)-4-[2-[[(2S)-1-[(2S)-2-[[(1S)-1-carboxy-2-phenylethyl]carbamoyl]pyrrolidin-1-yl]-3-(1H-imidazol-5-yl)-1-oxopropan-2-yl]amino]-2-oxoethyl]-2-[(4-hydroxyphenyl)methyl]-3-oxo-2,5-dihydro-1H-1,4-benzodiazepin-7-yl]amino]-3-methyl-1-oxobutan-2-yl]amino]-1-oxopropan-2-yl]amino]-4-oxobutanoic acid
  参考文献：
  名称：

  A Selective AT₂ Receptor Ligand with a γ-Turn-Like Mimetic Replacing the Amino Acid Residues 4−5 of Angiotensin II

  摘要：

  Three angiotensin II (Ang II) analogues encompassing a benzodiazepine-based gamma-turn-like scaffold have been synthesized. Evaluation of the compounds in a radioligand binding assay showed that they had no affinity to the rat liver AT(1) receptor. However, one of the compounds displayed considerable affinity to the pig uterus AT(2) receptor (K-i = 3.0 nM) while the other two lacked affinity to this receptor. It was hypothesized that the reason for the inactivity of one of these analogues to the AT(2) receptor was that the guanidino group of the Arg(2) residue and/or the N-terminal end of the pseudopeptide could not interact optimally with the receptor. To investigate this hypothesis, a conformational analysis was performed and a comparison was carried out with the monocyclic methylenedithioether analogue cyclo(S-CH2-S) [CyS3,5]-Ang II which is known to bind with high affinity to the AT(2) receptor (K-i = 0.62 nM). This comparison showed that, in the compounds with high AT(2) receptor affinity, the guanidino group of the Arg(2) residue and the N-terminal end could access common regions of space that were not accessible to the inactive compound. To examine the importance of the guanidino group for binding, the Arg side chain was removed by substituting Arg(2) for Ala(2) in the analogue having the high affinity. This analogue lacked affinity to AT(2) receptors, which supports the role of the guanidino group in receptor binding.

  DOI：

  10.1021/jm030921v
• 作为产物：
  描述：

  氯甲酸-9-芴基甲酯 、 在 sodium carbonate 作用下， 以 1,4-二氧六环 为溶剂， 反应 24.0h， 以57 mg的产率得到[(2S)-7-(9H-fluoren-9-ylmethoxycarbonylamino)-2-(4-hydroxybenzyl)-3-oxo-1,2,3,5-tetrahydrobenzo[1,4]diazepin-4-yl]acetic acid
  参考文献：
  名称：

  A Selective AT₂ Receptor Ligand with a γ-Turn-Like Mimetic Replacing the Amino Acid Residues 4−5 of Angiotensin II

  摘要：

  Three angiotensin II (Ang II) analogues encompassing a benzodiazepine-based gamma-turn-like scaffold have been synthesized. Evaluation of the compounds in a radioligand binding assay showed that they had no affinity to the rat liver AT(1) receptor. However, one of the compounds displayed considerable affinity to the pig uterus AT(2) receptor (K-i = 3.0 nM) while the other two lacked affinity to this receptor. It was hypothesized that the reason for the inactivity of one of these analogues to the AT(2) receptor was that the guanidino group of the Arg(2) residue and/or the N-terminal end of the pseudopeptide could not interact optimally with the receptor. To investigate this hypothesis, a conformational analysis was performed and a comparison was carried out with the monocyclic methylenedithioether analogue cyclo(S-CH2-S) [CyS3,5]-Ang II which is known to bind with high affinity to the AT(2) receptor (K-i = 0.62 nM). This comparison showed that, in the compounds with high AT(2) receptor affinity, the guanidino group of the Arg(2) residue and the N-terminal end could access common regions of space that were not accessible to the inactive compound. To examine the importance of the guanidino group for binding, the Arg side chain was removed by substituting Arg(2) for Ala(2) in the analogue having the high affinity. This analogue lacked affinity to AT(2) receptors, which supports the role of the guanidino group in receptor binding.

  DOI：

  10.1021/jm030921v