| 1058035-43-0

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪类
• CAS: 1058035-43-0
• 化学式: C₁₇H₃₁N₂O₇P
• 分子量: 406.416
• InChiKey: DIAORDHCVOZGQU-OAHLLOKOSA-N

反应信息

• 作为反应物：
  描述：

  在 全氟丁基磺酰氟 、 1,8-二氮杂双环[5.4.0]十一碳-7-烯 作用下， 以 甲苯 为溶剂， 生成
  参考文献：
  名称：

  Syntheses of Pyrimidine Acyclic Nucleoside Phosphonates as Potent Inhibitors of Thymidine Phosphorylase (PD-ECGF) from SD-Lymphoma

  摘要：

  In the present study, we synthesized a series of pyrimidine acyclic nucleoside phosphonates bearing a number of substituents in C-5 position of uracil moiety and in the N-1-side chain. In addition, we have investigated in particular the novel syntheses of fluorinated derivatives substituted in the N-1-side chain and uracil C-5 position because fluorine-containing substituents are often powerful modifiers of chemical and biological properties. The obtained compounds exhibit a considerable inhibitory potency of thymidine phosphorylase from SD-lymphoma. In contrast, the synthesized phosphonates are not efficient inhibitors of E. coli and human thymidine phosphorylase.

  DOI：

  10.1080/15257770701508679