[4-Benzyloxy-3-(4-methoxycarbonyl-phenoxy)-benzyl]-triphenyl-phosphonium | 139963-01-2

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: [4-Benzyloxy-3-(4-methoxycarbonyl-phenoxy)-benzyl]-triphenyl-phosphonium
• CAS: 139963-01-2
• 化学式: C₄₀H₃₄O₄P
• 分子量: 609.681
• InChiKey: GGCABEVNTXVRKS-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  8.34
• 重原子数：
  45.0
• 可旋转键数：
  11.0
• 环数：
  6.0
• sp3杂化的碳原子比例：
  0.07
• 拓扑面积：
  44.76
• 氢给体数：
  0.0
• 氢受体数：
  4.0

反应信息

• 作为反应物：
  描述：

  [4-Benzyloxy-3-(4-methoxycarbonyl-phenoxy)-benzyl]-triphenyl-phosphonium 、 Methyl 4-benzyloxy-2-(4-benzyloxy-2-formylphenyl)-5-methoxybenzoate 在 sodium methylate 作用下， 以 甲醇 为溶剂， 以83%的产率得到(E)- and (Z)-1-<5-Benzyloxy-2-(5-benzyloxy-2-methoxycarbonyl-4-methoxyphenyl)-phenyl>-2-<4-benzyloxy-4-(4-methoxycarbonylphenoxy)phenyl>-ethene
  参考文献：
  名称：

  Total synthesis of plagiochins C and D, macrocyclic bis(bibenzyl) constituents of plagiochila acantophylla

  摘要：

  Plagiochins C (3) and D (4) were synthesized by convergent schemes. Rings C and B were joined by Ullman ether synthesis, the aryl-aryl bond between rings A and D was formed by Pd(0)-catalysed coupling of an arylboronic acid (ring D) and a bromobenzoic ester (ring A). Ring C and D were linked by the Wittig reaction, while final ring closure was effected by tetraphenylethene assisted Wurtz reaction.

  DOI：

  10.1016/s0040-4020(01)88193-x