| 1017965-05-7

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• CAS: 1017965-05-7
• 化学式: C₁₈H₂₇NO₁₁P₂
• 分子量: 495.36
• InChiKey: AKEKZIRDKJCVLU-NZQIIRQASA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.7
• 重原子数：
  32.0
• 可旋转键数：
  10.0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.56
• 拓扑面积：
  166.92
• 氢给体数：
  3.0
• 氢受体数：
  9.0

反应信息

• 作为产物：
  描述：

  (2R,3R,4S,5S)-5-((benzyl(ethoxy)phosphoryl)amino)-2-((bis(benzyloxy)phosphoryl)oxy)tetrahydro-2H-pyran-3,4-diyl diacetate 在 palladium on activated charcoal 氢气 作用下， 以 甲醇 为溶剂， 生成
  参考文献：
  名称：

  Synthesis of and evaluation of lipid A modification by 4-substituted 4-deoxy arabinose analogs as potential inhibitors of bacterial polymyxin resistance

  摘要：

  Three sets of novel 4-deoxy-L-arabinose analogs were synthesized and evaluated as potential inhibitors of the bacterial resistance mechanism in which lipid A, on the outer membrane, is modified with 4-amino-4-deoxy-L-arabinose (L-Ara4N). One compound diminished the transfer of L-Ara4N onto lipid A. These results suggest that small molecules might be designed that would effect the same reversal of bacterial resistance observed in genetic knockouts. (c) 2007 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2007.12.061