Methods of diagnosing and/or of treating tumors by administering a nucleoside analogue which is activated by thymidylate synthase and/or thymidine kinase enzyme into a diagnostic or toxic metabolite, and uridine analogue compounds, and compositions of same having a pharmaceutically acceptable carrier. For diagnostic applications, compounds containing a label and methods of use of such compounds are described.
通过向患者施用由胸腺
嘧啶酸合成酶和/或胸腺
嘧啶激酶酶激活的核苷类似物,使其转化为诊断或毒性代谢产物,以及尿
嘧啶类似物化合物,以及具有药学可接受载体的组合物,来诊断和/或治疗肿瘤的方法。对于诊断应用,描述了含有标签的化合物以及使用这些化合物的方法。