N'-(4-aminobutyl)-N'-[4-[bis(4-aminobutyl)amino]butyl]butane-1,4-diamine | 139035-38-4

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: N'-(4-aminobutyl)-N'-[4-[bis(4-aminobutyl)amino]butyl]butane-1,4-diamine
• CAS: 139035-38-4
• 化学式: C₂₀H₄₈N₆
• 分子量: 372.641
• InChiKey: DHGXLBQYDMWXFX-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.1
• 重原子数：
  26
• 可旋转键数：
  21
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  111
• 氢给体数：
  4
• 氢受体数：
  6

反应信息

• 作为反应物：
  描述：

  N'-(4-aminobutyl)-N'-[4-[bis(4-aminobutyl)amino]butyl]butane-1,4-diamine 、 (S)-4-citronellyloxybenzoic acid 以 四氢呋喃 为溶剂， 反应 0.25h， 生成
  参考文献：
  名称：

  树突状离子液晶的研究：（S）-4-香茅酰氧基苯甲酸和聚丙烯亚胺树状聚合物的使用

  摘要：

  为了研究大分子结构与介晶性质之间的关系；树状离子液晶已经通过常规方法或微波辅助合成技术合成，并通过光谱学方法进行了表征（FT-IR，1 H-NMR，131 H-NMR）。使具有越来越多的氨基末端基团（DABn; n = 4，8，16，32）的基于二氨基丁烷（DAB）的聚丙烯亚胺（PPI）树状大分子与（S）-4-香茅基氧基苯甲酸（S-CBA）相互作用已经具有液晶性质。这些相互作用可以通过超声处理获得季铵盐，也可以通过使用适当的偶联剂进行共价连接。通过差示扫描量热法（DSC）和偏振光学显微镜（POM）研究了树枝状分子的液晶性质。通过热重分析（TGA）研究了热稳定性。合成的离子配合物显示出非倾斜的近晶中间相，其介晶范围比单个介晶单元的介晶范围宽，而那些通过共价键产生的衍生物则没有介晶相。

  DOI：

  10.1016/j.molliq.2015.12.070
• 作为产物：
  描述：

  N,N,N',N'-tetra(4-phthalimidobutyl)-1,4-diaminobutane 在 乙醇 、 一水合肼 作用下， 生成 N'-(4-aminobutyl)-N'-[4-[bis(4-aminobutyl)amino]butyl]butane-1,4-diamine
  参考文献：
  名称：

  [EN] POLYVALENT MOLECULE BASED LIPID NANOPARTICLES FOR NUCLEIC ACID DELIVERY
  [FR] NANOPARTICULES LIPIDIQUES À BASE DE MOLÉCULES POLYVALENTES POUR L'ADMINISTRATION D'ACIDES NUCLÉIQUES

  摘要：

  The invention relates to nanoparticles particularly for nanoparticles suitable for the delivery of a nucleic acid to a cell. The nanoparticles comprise polyvalent molecules to stabilise the nucleic acid molecules in the nanoparticles. Particularly the polyvalent molecules have a dendrimer like structure. The invention further relates to manufacturing nanoparticles, and uses of such nanoparticles in the treatment of a disease.

  公开号：

  WO2023233042A1

文献信息

• A novel nickel (II) complex based on a cyclam-cored generation-one dendrimeric salicylaldimine ligand and its application as a catalyst precursor in norbornene polymerization: Comparative study with some other first generation DAB-polypropyleneimine metallodendrimers
  作者：Rehana Malgas-Enus、Selwyn F. Mapolie

  DOI：10.1016/j.poly.2012.08.015

  日期：2012.10

  A new cyclam based first generation metallodendrimer with nickel centres on the periphery as well as at the core was synthesized by reacting a novel tetrakis(salicylaldimine) cyclam ligand with nickel acetate. The trinuclear complex was evaluated as a catalyst precursor in the vinyl polymerization of norbornene using methylaluminoxane as co-catalyst. The activity of this cyclam-based complex was compared with that of first generation DAB-PPI-salicylaldimine and DAB-PPI-pyridine-imine complexes (DAB = diaminobutane, PPI = polypropyleneimine). The cyclam based complex was found to have superior activity than both the DAB-PPI analogues as well as analogous mononuclear complexes. (c) 2012 Elsevier Ltd. All rights reserved.
• PGSE NMR Studies on DAB-Organo-Rhodium Dendrimers:  Evaluation of the Molecular Size, Self-Aggregation Tendency, and Surface Metal Density
  作者：Daniele Zuccaccia、Luigi Busetto、M. Cristina Cassani、Alceo Macchioni、Rita Mazzoni

  DOI：10.1021/om0600240

  日期：2006.4.1

  PGSE NMR measurements have been carried out for DAB-dendr-(NH2)(n) [n = 4 (Dab4), 8 (Dab8), 16 (Dab16), 32 (Dab32), and 64 (Dab64)] and DAB-dendr-[NH(O)COCH2CH2OC(O)C5H4Rh(NBD)](n) [n = 4 (Rh-Dab4), 8 (Rh-Dab8), 16 (Rh-Dab16), 32 (Rh-Dab32), and 64 (Rh-Dab64)] in CD2Cl2 and CD3OD as a function of the concentration. The hydrodynamic radius (r(H)) and, consequently, the hydrodynamic volume (V-H) of all the species are determined from the measured translational self-diffusion coefficients (D-t). In CD2Cl2, both Dab and Rh-Dab dendrimers show a tendency toward self-aggregation that increases with the generations. In addition, while the radii r(H) for Dab dendrimers is ca. 20-30% higher in CD3OD than in CD2Cl2, the r(H) values for Rh-Dab dendrimers are only slightly influenced by solvent variation. To estimate the Rh-Rh spatial proximity (d(Rh/Rh)) on the surface, the internal radius (r(int)) of the Dab skeleton in Rh-Dab dendrimers was (i) considered equal to that of the Dab dendrimers (model A) or (ii) evaluated assuming that the additional solvent molecules derived from the attachment of Rh to Dab dendrimers were incorporated into the elongated dendritic skeleton (model B). It was found that dRh/Rh decreases from 17.2-19.8 angstrom (Rh-Dab4) to about 14.0 angstrom (Rh-Dab64) with the increase in dendrimer generation.