(1-phenethyl-aziridin-2-yl)-methanol | 99858-55-6

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: (1-phenethyl-aziridin-2-yl)-methanol
• 英文别名: (1-Phenaethyl-aziridin-2-yl)-methanol；[1-(2-Phenylethyl)aziridin-2-yl]methanol
• CAS: 99858-55-6
• 化学式: C₁₁H₁₅NO
• 分子量: 177.246
• InChiKey: ITGFEZVHKHWJDV-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.4
• 重原子数：
  13
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.45
• 拓扑面积：
  23.2
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  alkaline earth salt of/the/ methylsulfuric acid 在 四氢呋喃 、 lithium aluminium tetrahydride 作用下， 生成 (1-phenethyl-aziridin-2-yl)-methanol
  参考文献：
  名称：

  取代的亚乙基亚胺羧酸酯和亚乙基亚胺甲醇的表征和性能†

  摘要：

  相应的乙烯亚胺甲醇可以通过用氢化铝锂还原取代的乙烯亚胺羧酸酯来获得。描述了它们的性质和一些衍生物的表示。

  DOI：

  10.1002/hlca.19570400612

文献信息

• USE OF 1- BENZYL-1- HYDROXY-2, 3-DIAMINO-PROPYL AMINES, 3-BENZYL-3 HYDROXY-2-AMINO PROPIONIC ACID AMIDES AND RELATED COMPOUNDS AS ANALGESICS
  申请人：ALLERGAN, INC.

  公开号：EP1841423A2

  公开（公告）日：2007-10-10
• [EN] PROCESS FOR PREPARING 2,3-DIAMINOPROPANOLS AND SYNTHESIS OF OTHER COMPOUNDS USING 2,3-DIAMINOPROPANOLS<br/>[FR] ÉLABORATION DE 2,3-DIAMINOPROPANOLS ET SYNTHÈSE D'AUTRES COMPOSÉS PAR UTILISATION DE 2,3-DIAMINOPROPANOLS
  申请人：CHEMBIONEX CO LTD

  公开号：WO2002012185A1

  公开（公告）日：2002-02-14

  The invention relates to a process for producing 2,3-diaminopropanol of formula (II) from aziridine of formula (I) wherein, R1 is selected from a group consisting of hydrogen, alkyl, cycloalkyl, acyl, aryl, hydrocarbon residues, aralkyl, and those groups substituted with suitable substituent(s); R2 is selected from a group consisting of hydrogen, alkyl, cycloalkyl, C¿2?-C5-alkenyl, aralkyl which may be optionally substituted with suitable substituent(s), aryl which may be optionally substituted with suitable substituent(s), and heteroaryl which may be optionally substituted with suitable substituent(s); each of R?3 and R4¿ is independently selected from a group consisting of hydrogen, C¿1?-C12 alkyl, C1-C12 alkylcarbonyl, C1-C12 alkyloxycarbonyl, aryl, mono- or di(C1-C12)alkylamino, mono- or di(C1-C12)amino carbonyl, wherein C1-C12 may be optionally substituted, or R?3 and R4¿, together with nitrogen atom which they are attached to, may form pyrrolidinyl, piperidinyl, morpholinyl, azido or mono- or di(C¿1?-C12)alkylamino C1-C4 alkylidene.
• [EN] METHODS OF USING AS ANALGESICS 1-BENZYL-1-HYDROXY-2, 3-DIAMINO-PROPYL AMINES, 3-BENZYL-3-HYDROXY-2-AMINO-PROPIONIC ACID AMIDES AND RELATED COMPOUNDS<br/>[FR] METHODES D'UTILISATION COMME ANALGESIQUES DE 1-BENZYL-1-HYDROXY-2, DE 3-DIAMINO-PROPYL AMINES, D'AMIDES D'ACIDE 3-BENZYL-3-HYDROXY-2-AMINO-PROPIONIQUE ET DE LEURS COMPOSES
  申请人：ALLERGAN INC

  公开号：WO2006081252A2

  公开（公告）日：2006-08-03

  [EN] The compounds shown by the structural formulas below have analgesic effect and are used in compositions and methods for treating mammal in need of such treatment.
  [FR] Les composés des formules structurelles (A) indiquées ci-après ont des effets analgésiques et sont utilisés dans les compositions et dans les méthodes de traitement de mammifères nécessitant ce type de traitement.