tert-butyl 4(S)-(2(S)-azidomethyl-3-methylbutyl)-2,2-dimethyl-oxazolidine-3-carboxylate | 861451-11-8

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑烷类
• 英文名称: tert-butyl 4(S)-(2(S)-azidomethyl-3-methylbutyl)-2,2-dimethyl-oxazolidine-3-carboxylate
• 英文别名: tert-Butyl 4(S)-(2(S)-azidomethyl-3-methylbutyl)-2,2-dimethyloxazolidine-3-carboxylate；tert-butyl (4S)-4-[(2S)-2-(azidomethyl)-3-methylbutyl]-2,2-dimethyl-1,3-oxazolidine-3-carboxylate
• CAS: 861451-11-8
• 化学式: C₁₆H₃₀N₄O₃
• 分子量: 326.439
• InChiKey: FRUDIYFZCMYZCH-OLZOCXBDSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.4
• 重原子数：
  23
• 可旋转键数：
  7
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.94
• 拓扑面积：
  53.1
• 氢给体数：
  0
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  tert-butyl 4(S)-(2(S)-azidomethyl-3-methylbutyl)-2,2-dimethyl-oxazolidine-3-carboxylate 在 palladium 10% on activated carbon 氢气 作用下， 以 乙酸乙酯 为溶剂， 反应 1.0h， 生成 tert-butyl 4(S)-(2(S)-aminomethyl-3-methylbutyl)-2,2-dimethyloxazolidine-3-carbamate
  参考文献：
  名称：

  [EN] AMINO ALCOHOL DERIVATIVES AND THEIR ACTIVITY AS RENIN INHIBITORS
  [FR] COMPOSES ORGANIQUES

  摘要：

  公开号：

  WO2005070871A3
• 作为产物：
  描述：

  tert-butyl 4(S)-(2(S)-methanesulphonyloxymethyl-3-methylbutyl)-2,2-dimethyloxazolidine-3-carboxylate 在 N,N-二甲基丙烯基脲 、 sodium azide 作用下， 反应 3.0h， 生成 tert-butyl 4(S)-(2(S)-azidomethyl-3-methylbutyl)-2,2-dimethyl-oxazolidine-3-carboxylate
  参考文献：
  名称：

  [EN] AMINO ALCOHOL DERIVATIVES AND THEIR ACTIVITY AS RENIN INHIBITORS
  [FR] COMPOSES ORGANIQUES

  摘要：

  公开号：

  WO2005070871A3

文献信息

• Amino alcohol derivatives and their activity as renin inhibitors
  申请人：Herold Peter

  公开号：US20070155743A1

  公开（公告）日：2007-07-05

  The application relates to novel amino alcohols of general formula (I) where R, R 1 , R 2 , R 3 , R 4 , R 5 ,X 1 and X 2 each have the definitions illustrated in detail in the description, to a process for their preparation and to the use of these compounds as medicines, in particular as renin inhibitors.

  本申请涉及一种新型氨基醇，其一般式为（I），其中R、R1、R2、R3、R4、R5、X1和X2分别具有详细描述中所示的定义，以及它们的制备方法和这些化合物作为药物的用途，特别是作为肾素抑制剂。
• AMINO ALCOHOL DERIVATIVES AND THEIR ACTIVITY AS RENIN INHIBITORS
  申请人：Speedel Experimenta AG

  公开号：EP1756037A2

  公开（公告）日：2007-02-28
• US7786307B2
  申请人：——

  公开号：US7786307B2

  公开（公告）日：2010-08-31
• [EN] ORGANIC COMPOUNDS<br/>[FR] COMPOSES ORGANIQUES
  申请人：SPEEDEL EXPERIMENTA AG

  公开号：WO2005070871A2

  公开（公告）日：2005-08-04

  The application relates to novel amino alcohols of general formula (I) where R, R1, R2, R3, R4, R5, X1 and X2 each have the definitions illustrated in detail in the description, to a process for their preparation and to the use of these compounds as medicines, in particular as renin inhibitors.
• [EN] AMINO ALCOHOL DERIVATIVES AND THEIR ACTIVITY AS RENIN INHIBITORS<br/>[FR] COMPOSES ORGANIQUES
  申请人：SPEEDEL EXPERIMENTA AG

  公开号：WO2005070871A3

  公开（公告）日：2005-09-22