2-Chloro-8-hydroxy-6-methoxy-7-propyl-benzo[e]pyrrolo[2,1-b][1,3]oxazin-9-one

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯酚醚
• 英文名称: 2-Chloro-8-hydroxy-6-methoxy-7-propyl-benzo[e]pyrrolo[2,1-b][1,3]oxazin-9-one
• 英文别名: 2-Chloro-8-hydroxy-6-methoxy-7-propylpyrrolo[2,1-b][1,3]benzoxazin-9-one
• 化学式: C₁₅H₁₄ClNO₄
• 分子量: 307.733
• InChiKey: ONOQBUDQDSXQNQ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.3
• 重原子数：
  21
• 可旋转键数：
  3
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.27
• 拓扑面积：
  60.7
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  重氮甲烷 、 Streptopyrrole 在 silica gel 作用下， 以 乙醚 为溶剂， 以2.3 mg的产率得到2-Chloro-8-hydroxy-6-methoxy-7-propyl-benzo[e]pyrrolo[2,1-b][1,3]oxazin-9-one
  参考文献：
  名称：

  Streptopyrrole: an Antimicrobial Metabolite from Streptomyces armeniacus.

  摘要：

  A colourless, crystalline metabolite, C14H12ClNO4, named streptopyrrole, has been isolated from submerged fermentation cultures of Streptomyces armeniacus by extraction, followed by chromatographic purification. Its tricyclic molecular framework, seemingly without natural product precedents. as well as its substitution pattern were derived from extensive NMR analysis including H-1-detected INADEQUATE experiments. Streptopyrrole exhibits weak growth inhibitory effect towards a broad range of microorganisms.

  DOI：

  10.3891/acta.chem.scand.52-1040

文献信息

• US6057315A
  申请人：——

  公开号：US6057315A

  公开（公告）日：2000-05-02
• Streptopyrrole: an Antimicrobial Metabolite from Streptomyces armeniacus.
  作者：Jens Breinholt、Hanne Gürtler、Anders Kjær、Salka E. Nielsen、Carl E. Olsen、Kirsi Ranta、Teófilo Rojo

  DOI：10.3891/acta.chem.scand.52-1040

  日期：——

  A colourless, crystalline metabolite, C14H12ClNO4, named streptopyrrole, has been isolated from submerged fermentation cultures of Streptomyces armeniacus by extraction, followed by chromatographic purification. Its tricyclic molecular framework, seemingly without natural product precedents. as well as its substitution pattern were derived from extensive NMR analysis including H-1-detected INADEQUATE experiments. Streptopyrrole exhibits weak growth inhibitory effect towards a broad range of microorganisms.