4-(2-Hydroxy-phenyl)-2,6-dimethyl-pyridine-3,5-dicarboxylic acid diethyl ester | 66686-04-2

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 英文名称: 4-(2-Hydroxy-phenyl)-2,6-dimethyl-pyridine-3,5-dicarboxylic acid diethyl ester
• 英文别名: Diethyl 4-(2-hydroxyphenyl)-2,6-dimethylpyridine-3,5-dicarboxylate
• CAS: 66686-04-2
• 化学式: C₁₉H₂₁NO₅
• 分子量: 343.379
• InChiKey: MBFODZHLWQZIRY-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.4
• 重原子数：
  25
• 可旋转键数：
  7
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.32
• 拓扑面积：
  85.7
• 氢给体数：
  1
• 氢受体数：
  6

反应信息

• 作为产物：
  描述：

  diethyl 4-(2-hydroxyphenyl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate 在 manganese(III) meso-tetra(4-pyridyl)porphyrin on polystyrene sodium periodate 作用下， 以 水 、 乙腈 为溶剂， 反应 2.33h， 生成 4-(2-Hydroxy-phenyl)-2,6-dimethyl-pyridine-3,5-dicarboxylic acid diethyl ester
  参考文献：
  名称：

  Biomimetic aromatization of Hantzsch 1,4-dihydropyridines with sodium periodate catalyzed by a new polystyrene-bound manganese porphyrin

  摘要：

  报道了聚苯乙烯-锰(III)卟啉催化的过氧化钠对Hantzsch 1,4-二氢吡啶的高效氧化。该催化剂在室温下对各种1,4-二氢吡啶的氧化表现出高活性。这种非均相催化剂可重复使用五次而不显著降低其活性。关键词：仿生氧化，支持金属卟啉，过碘酸盐，1,4-二氢吡啶。

  DOI：

  10.1139/v05-255

文献信息

• Rapid and efficient oxidation of Hantzsch 1,4-dihydropyridines with sodium periodate catalyzed by manganese (III) Schiff base complexes
  作者：Masoud Nasr-Esfahani、Majid Moghadam、Shahram Tangestaninejad、Valiollah Mirkhani、Ahmad Reza Momeni

  DOI：10.1016/j.bmc.2005.11.051

  日期：2006.4

  Rapid and efficient oxidation of Hantzsch 1,4-dihydropyridine with sodium periodate is reported. The Mn(III)-salophen/NaIO4 catalytic system converts 1,4-dihydropyridines to their corresponding pyridine derivatives at room temperature in a 1:1, CH3CN/H2O mixture. The ability of various Schiff base complexes in the oxidation of 1,4-dihydropyridine was also investigated.

  据报道，高碘酸钠可快速有效地氧化Hantzsch 1,4-二氢吡啶。Mn（III）-salophen / NaIO4催化体系在室温下以1：1的CH3CN / H2O混合物将1,4-二氢吡啶转化为其相应的吡啶衍生物。还研究了各种席夫碱配合物在1,4-二氢吡啶氧化中的能力。
• USE OF CERTAIN MANGANESE-ACCUMULATING PLANTS FOR CARRYING OUT ORGANIC CHEMISTRY REACTIONS
  申请人：CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE

  公开号：US20150174566A1

  公开（公告）日：2015-06-25

  The use, after heat treatment, of manganese accumulating plants for carrying out chemical reactions.

  经过热处理后，利用富集锰的植物进行化学反应。
• Room Temperature Catalytic Aromatization of Hantzsch 1,4-Dihydropyridines by Sodium Nitrite in the Presence of Acidic Silica Gel
  作者：Mohammed M. Hashemi、Hossein Ghafuri、Zahed Karimi-Jaberi

  DOI：10.1007/s00706-005-0425-5

  日期：2006.2

  Various alkyl, aryl, and heterocyclic Hantzsch 1,4-dihydropyridines were converted to the corresponding pyridines in excellent yields and short times using sodium nitrite in the presence of a catalytic amount of acidic silica gel at room temperature.

  在室温下，在催化量的酸性硅胶存在下，使用亚硝酸钠以优异的收率和短时间将各种烷基，芳基和杂环的 Hantzsch 1,4-二氢吡啶转化为相应的吡啶。
• Use of certain manganese-accumulating plants for carrying out organic chemistry reactions
  申请人：CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE

  公开号：US10702860B2

  公开（公告）日：2020-07-07

  The use, after heat treatment, of manganese accumulating plants for carrying out chemical reactions.

  利用经过热处理的蓄锰植物进行化学反应。
• Biomimetic oxidation of Hantzsch 1,4-dihydropyridines with tetra-n-butylammonium periodate catalyzed by tetraphenylporphyrinatomanganese(III) chloride [Mn(TPP)Cl]
  作者：Masoud Nasr-Esfahani、Majid Moghadam、Shahram Tangestaninejad、Valiollah Mirkhani

  DOI：10.1016/j.bmcl.2005.04.044

  日期：2005.7

  Efficient oxidation of Hantzsch 1,4-dihydropyridines to their corresponding pyridine derivatives with (BU4N)IO4 catalyzed by tetraphenylporphyrinatomanganese(III) chloride [Mn(TPP)Cl] is reported. This catalytic system shows high efficiency in the oxidation of 1,4-dihydropyridines at room temperature in the presence of imidazole. (c) 2005 Published by Elsevier Ltd.