3-(丙酰氧基)苯甲酸 | 51988-36-4

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯酚酯
• 中文名称: 3-(丙酰氧基)苯甲酸
• 英文名称: 3-propionyloxy-benzoic acid
• 英文别名: 3-Propionyloxy-benzoesaeure；3-(Propionyloxy)benzoic acid；3-propanoyloxybenzoic acid
• CAS: 51988-36-4
• 化学式: C₁₀H₁₀O₄
• 分子量: 194.187
• InChiKey: KDSHSYUJJSWWNU-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.3
• 重原子数：
  14
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.2
• 拓扑面积：
  63.6
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  丙酸酐 、 间羟基苯甲酸 生成 3-(丙酰氧基)苯甲酸
  参考文献：
  名称：

  HOFSTEE, Journal of Biological Chemistry, 1954, vol. 207, # 1, p. 219 - 224

  摘要：

  DOI：

文献信息

• BENZAMIDE DERIVATIVES AND THEIR USE FOR TREATING CNS DISORDERS
  申请人：Galley Guido

  公开号：US20090036420A1

  公开（公告）日：2009-02-05

  The present invention relates to methods of treating CNS disorders with a compound of formula I wherein X, R 1 , R 2 , R 3 , R 4 , R 5 , R 6 , R 7 , and R 8 are as defined in the specification and pharmaceutically acceptable acid addition salts thereof.

  本发明涉及使用式I中的化合物治疗中枢神经系统疾病的方法，其中X、R1、R2、R3、R4、R5、R6、R7和R8如说明书中所定义，并且包括药学上可接受的酸盐。
• [EN] MORPHOLINYLMETHYLUREAS CCR-3 RECEPTOR ANTAGONISTS<br/>[FR] ANTAGONISTES DU RECEPTEUR DE MORPHOLINYLMETHYLUREE CCR-3
  申请人：GLAXO GROUP LTD

  公开号：WO2003097618A1

  公开（公告）日：2003-11-27

  Compounds of formula (I'): (I); wherein: R1 represents substituted or unsubstituted aryl or substituted or unsubstituted heteroaryl; X represents -(CRkaRkb)k-; Rka and Rkb are each independently hydrogen or C1-6alkyl; k is 0-5; Y represents -NR3- or a bond; R3 represents hydrogen or C1-6alkyl; Z represents a moiety of formula (ZA), (ZB), (ZC), (ZD), (ZE), or (ZF); A represents -(CRjaRjb)j-; Rja and Rjb are each independently hydrogen or C1-6alkyl; j is 0, 1 or 2, and; R2 represents unsubstituted or substituted aryl; and salts and solvates thereof are CCR3 receptor antagonists and are thus indicated to be useful in therapy.

  公式（I'）的化合物：（I）; 其中：R1代表取代或未取代的芳基或取代或未取代的杂环芳基; X代表-(CRkaRkb)k-; Rka和Rkb分别独立地表示氢或C1-6烷基; k为0-5; Y表示-NR3-或键; R3表示氢或C1-6烷基; Z表示公式（ZA）、（ZB）、（ZC）、（ZD）、（ZE）或（ZF）的基团; A表示-(CRjaRjb)j-; Rja和Rjb分别独立地表示氢或C1-6烷基; j为0、1或2，且; R2表示未取代或取代的芳基; 其盐和溶剂化物为CCR3受体拮抗剂，因此被认为在治疗中有用。
• Process for producing aromatic liquid crystalline polyester and film thereof
  申请人：Sumitomo Chemical Company, Limited

  公开号：EP1081173A2

  公开（公告）日：2001-03-07

  Provided is a process for producing an aromatic liquid crystalline polyester comprising the steps of: charging into a reaction vessel 80 to 20 mol% of a compound of formula (I) and 20 to 80 mol% of a compound of formula (II): wherein R1 represents a hydrogen atom, formyl group, acetyl group, propionyl group or benzoyl group, R2 represents a hydrogen atom, methyl group, ethyl group, propyl group, benzyl group or phenyl group, the R1 groups in formulae (I) and (II) may be the same as or different from each other, and the R2 groups in formulae (I) and (II) may be the same as or different from each other; conducting a polycondensation reaction of the charged mixture at a temperature from 270 to 350°C to produce an aromatic liquid crystalline polyester having a flow temperature of 210°C or more and lower than the polycondensation reaction temperature by 30°C or more; discharging the aromatic liquid crystalline polyester in a molten state from the reaction vessel and solidifying; then, pulverizing the solidified polyester into particles having a particle size of 3 mm or less; and heat-treating at a temperature from 200 to 310°C still in the solid state under an inert gas atmosphere; wherein the flow temperature means the temperature (°C) at which the melt viscosity measured by a capillary type rheometer is 48,000 poise when a resin which has been melted by heating at a temperature raising rate of 4°C/min is extruded through a nozzle having an internal diameter of 1 mm and a length of 10 mm under a load of 100 kgf/cm2. The aromatic liquid crystalline polyester has improved low temperature molding processability, and the film thereof has sufficient heat-resistance and excellent gas barrier properties.

  本发明提供了一种生产芳香族液晶聚酯的工艺，包括以下步骤 在反应容器中加入 80 至 20 摩尔%的式 (I) 化合物和 20 至 80 摩尔%的式 (II) 化合物： 其中 R1 代表氢原子、甲酰基、乙酰基、丙酰基或苯甲酰基，R2 代表氢原子、甲基、乙基、丙基、苄基或苯基，式 (I) 和 (II) 中的 R1 基团可以相同或不同，式 (I) 和 (II) 中的 R2 基团可以相同或不同； 在 270 至 350°C 的温度下对加料混合物进行缩聚反应，生成芳香族液态结晶聚酯，其流动温度为 210°C 或以上，并比缩聚反应温度低 30°C 或以上； 将熔融状态的芳香族液态结晶聚酯从反应容器中排出并凝固； 然后，将凝固的聚酯粉碎成粒径为 3 毫米或以下的颗粒；以及 在惰性气体环境下，以 200 至 310°C 的温度对仍处于固态的聚酯进行热处理； 其中，流动温度是指在 100 kgf/cm2 的载荷下，以 4°C/min 升温速率加热熔化的树脂，通过内径为 1 毫米、长度为 10 毫米的喷嘴挤出时，用毛细管流变仪测得的熔体粘度为 48,000 poise 的温度（°C）。 这种芳香族液晶聚酯改善了低温成型加工性，其薄膜具有足够的耐热性和优异的气体阻隔性。
• Aromatic liquid crystalline polyester resin and resin composition thereof
  申请人：Sumitomo Chemical Company, Limited

  公开号：EP0964014B1

  公开（公告）日：2004-08-18
• METHOD FOR PRODUCING LIQUID CRYSTAL POLYESTER
  申请人：OHTOMO Shinji

  公开号：US20120253060A1

  公开（公告）日：2012-10-04

  Disclosed is a method for producing a liquid crystal polyester, which includes the steps of: (1) polycondensing a mixture of 70.5 to 71.5 mol % of a compound represented by the defined formula (I) (for example, 4-acetoxybenzoic acid) with 28.5 to 29.5 mol % of a compound represented by the defined formula (II) (for example, 6-acetoxy-2-naphthoic acid) to form a prepolymer, wherein the prepolymer has a flow initiation temperature of 200° C. or higher, and the mixture is polycondensed until reaching the temperature which is at least 30° C. lower than the polycondensation temperature; (2) removing the prepolymer in a molten state, followed by solidification and further grinding to produce prepolymer particles; and (3) subjecting the prepolymer particles to a heat treatment at 200 to 310° C. under circulation of an inert gas while remaining in a solid phase state.