(2,6-bis-N-(propylamino)pyrimidin-4-yl)-N,O-dimethyl-hydroxylamine hydrogen sulfate | 1380342-54-0

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪类
• 英文名称: (2,6-bis-N-(propylamino)pyrimidin-4-yl)-N,O-dimethyl-hydroxylamine hydrogen sulfate
• 英文别名: 4-N-methoxy-4-N-methyl-2-N,6-N-dipropylpyrimidine-2,4,6-triamine;sulfuric acid
• CAS: 1380342-54-0
• 化学式: C₁₂H₂₃N₅O*H₂O₄S
• 分子量: 351.427
• InChiKey: YDNGVAVEWMTNER-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.47
• 重原子数：
  23
• 可旋转键数：
  8
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.67
• 拓扑面积：
  145
• 氢给体数：
  4
• 氢受体数：
  10

反应信息

• 作为产物：
  描述：

  4-chloro-2,6-bis-[n-propylamino]-1,3-pyrimidine 在 硫酸 、 sodium hydroxide 作用下， 以 1,4-二氧六环 、 水 为溶剂， 反应 96.5h， 生成 (2,6-bis-N-(propylamino)pyrimidin-4-yl)-N,O-dimethyl-hydroxylamine hydrogen sulfate
  参考文献：
  名称：

  [EN] NOVEL COMPOUNDS AS RESPIRATORY STIMULANTS FOR TREATMENT OF BREATHING CONTROL DISORDERS OR DISEASES
  [FR] NOUVEAUX COMPOSÉS COMME STIMULANTS RESPIRATOIRES POUR LE TRAITEMENT DE TROUBLES OU DE MALADIES DE CONTRÔLE DE LA RESPIRATION

  摘要：

  本发明涵盖了用于治疗患有呼吸控制疾病或紊乱的受试者的组合物。本发明还包括一种治疗患有呼吸系统疾病或紊乱的受试者的方法，包括向受试者施用本发明的药物配方的治疗有效量。本发明还包括一种预防或稳定患有呼吸节律不稳定的受试者的方法，包括向受试者施用本发明的药物配方的治疗有效量。

  公开号：

  WO2012074999A1

文献信息

• Breathing control modulating compounds, and methods of making and using same
  申请人：NEURAD LTD.

  公开号：US10294228B2

  公开（公告）日：2019-05-21

  The present invention includes compounds that are useful in the prevention and/or treatment of breathing control diseases or disorders in a subject in need thereof. The present invention also includes a method of preventing and/or treating a respiratory disease or disorder in a subject in need thereof, comprising administering to the subject a therapeutically effective amount of a compound and/or composition of the invention. The present invention further includes a method of preventing destabilization or stabilizing breathing rhythm in a subject in need thereof, comprising administering to the subject a therapeutically effective amount of a compound and/or composition of the invention.

  本发明包括可用于预防和/或治疗所需对象的呼吸控制疾病或紊乱的化合物。本发明还包括一种预防和/或治疗有需要的受试者的呼吸疾病或紊乱的方法，包括向受试者施用治疗有效量的本发明化合物和/或组合物。本发明还包括一种在有需要的受试者中预防不稳定或稳定呼吸节律的方法，包括向受试者施用治疗有效量的本发明化合物和/或组合物。
• Novel Breathing Control Modulating Compounds, and Methods of Making and Using Same
  申请人：GALLEON PHARMACEUTICALS, INC.

  公开号：US20180141953A1

  公开（公告）日：2018-05-24

  The present invention includes compounds that are useful in the prevention and/or treatment of breathing control diseases or disorders in a subject in need thereof. The present invention also includes a method of preventing and/or treating a respiratory disease or disorder in a subject in need thereof, comprising administering to the subject a therapeutically effective amount of a compound and/or composition of the invention. The present invention further includes a method of preventing destabilization or stabilizing breathing rhythm in a subject in need thereof, comprising administering to the subject a therapeutically effective amount of a compound and/or composition of the invention.