4-(3-methyl-2-oxoperhydropyrimidin-1-yl)piperidine | 164519-20-4

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪类
• 英文名称: 4-(3-methyl-2-oxoperhydropyrimidin-1-yl)piperidine
• 英文别名: 1-Methyl-3-(piperidin-4-yl)tetrahydropyrimidin-2(1h)-one；1-methyl-3-piperidin-4-yl-1,3-diazinan-2-one
• CAS: 164519-20-4
• 化学式: C₁₀H₁₉N₃O
• 分子量: 197.28
• InChiKey: DXRIZBVZZKKYJU-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0
• 重原子数：
  14
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.9
• 拓扑面积：
  35.6
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  在 盐酸 、 氨 作用下， 以 1,4-二氧六环 、 二氯甲烷 、 甲醇 为溶剂， 生成 4-(3-methyl-2-oxoperhydropyrimidin-1-yl)piperidine
  参考文献：
  名称：

  SUBSTITUTED OXIMES AND HYDRAZONES AS NEUROKININ ANTAGONISTS

  摘要：

  公开号：

  EP1144402B1

文献信息

• [EN] HETEROCYCLES USEFUL AS NEUROKININ ANTAGONISTS<br/>[FR] HETEROCYCLES APTES A ETRE UTILISES COMME ANTAGONISTES DE LA NEUROKININE
  申请人：ZENECA LIMITED

  公开号：WO1995005377A1

  公开（公告）日：1995-02-23

  (EN) Compounds of formula (I) wherein G, J, L, M, m and D have any of the meanings given in the specification, their N^_-oxides, and their pharmaceutically acceptable salts are nonpeptide antagonists of neurokinin A and useful for the treatment of asthma, etc. Also disclosed are pharmaceutical compositions, processes for preparing the compounds of formula (I) and intermediates.(FR) L'invention concerne des composés de la formule (I) dans laquelle G, J, L, M, m et D ont n'importe laquelle des significations données dans le descriptif de l'invention, leurs N^_-oxydes et leurs sels pharmaceutiquement acceptables sont des antagonistes non peptidiques de la neurokinine A et sont utiles dans le traitement de l'asthme, etc. L'invention concerne également des compositions pharmaceutiques, les procédés de préparation des composés de la formule (I) et leurs intermédiaires.

  化合物公式（I）中，G、J、L、M、m和D具有规范中给出的任何含义，它们的N^_-氧化物和药学上可接受的盐是神经激肽A的非肽拮抗剂，可用于治疗哮喘等疾病。还公开了制药组合物、制备化合物公式（I）和中间体的过程。
• Therapeutic heterocycles
  申请人：——

  公开号：US20030187255A1

  公开（公告）日：2003-10-02

  Pharmaceutical compositions containing novel therapeutic heterocycles for use in diseases in which an NK2 receptor is implicated, processes for preparing and methods for using the same.

  含有新型治疗杂环的药物组合物，用于与NK2受体有关的疾病，制备方法和使用方法。
• Cyclic Amide Derivative, and Its Production and Use
  申请人：Kubo Keiji

  公开号：US20070244118A1

  公开（公告）日：2007-10-18

  The present invention provides a cyclic amide derivative useful as a drug for treating thrombosis, which is represented by the formula (I)-: wherein R 1 represents an optionally substituted cyclic hydrocarbon group or an optionally substituted heterocyclic group, W represents a bond or an optionally substituted divalent chain hydrocarbon group, a represents 0, 1, or 2, X 1 represents an optionally substituted lower alkylene or an optionally substituted lower alkenylene, Y 1 represents —C(O)—, —S(O)— or —S(O) 2 —, A represents a piperazine ring which may be further substituted or a piperidine ring which may be further substituted, X 2 represents a bond or an optionally substituted lower alkylene, Y 2 represents —C(O)—, —S(O)—, —S(O) 2 — or —C(═NR 7 )—, X 3 represents an optionally substituted C 1-4 alkylene or an optionally substituted C 2-4 alkenylene, Z 3 represents —N(R 4 )—, —O— or a bond, Z 1 represents —C(R 2 )(R 2′ )—, —N(R 2 )—, etc., and Z 2 represents —C(R 3 )(R 3′ )—, —N(R 3 )—, etc., or a salt thereof.

  本发明提供了一种环酰胺衍生物，用作治疗血栓的药物，其化学式表示为(I)-:其中R1表示可选取代的环烃基或可选取代的杂环基，W表示键或可选取代的二价链烃基，a表示0、1或2，X1表示可选取代的较低烷基或可选取代的较低烯基，Y1表示—C(O)—、—S(O)—或—S(O)2—，A表示可进一步取代的哌嗪环或可进一步取代的哌啶环，X2表示键或可选取代的较低烷基，Y2表示—C(O)—、—S(O)—、—S(O)2—或—C(═NR7)—，X3表示可选取代的C1-4烷基或可选取代的C2-4烯基，Z3表示—N(R4)—、—O—或键，Z1表示—C(R2)(R2′)—、—N(R2)—等，Z2表示—C(R3)(R3′)—、—N(R3)—等，或其盐。
• Cyclic amide derivative, and its production and use
  申请人：Kubo Keiji

  公开号：US20080255352A1

  公开（公告）日：2008-10-16

  The present invention provides a cyclic amide derivative useful as a drug for treating thrombosis, which is represented by the formula (I): wherein R 1 represents an optionally substituted cyclic hydrocarbon group or an optionally substituted heterocyclic group, W represents a bond or an optionally substituted divalent chain hydrocarbon group, a represents 0, 1, or 2, X 1 represents an optionally substituted lower alkylene or an optionally substituted lower alkenylene, Y 1 represents —C(O)—, —S(O)— or —S(O) 2 —, A represents a piperazine ring which may be further substituted or a piperidine ring which may be further substituted, X 2 represents a bond or an optionally substituted lower alkylene, Y 2 represents —C(O)—, —S(O)—, —S(O) 2 — or —C(═NR 7 )—, X 3 represents an optionally substituted C 1-4 alkylene or an optionally substituted C 2-4 alkenylene, Z 3 represents —N(R 4 )—, —O— or a bond, Z 1 represents —C(R 2 )(R 2′ )—, —N(R 2 )—, etc., and Z 2 represents —C(R 3 )(R 3′ )—, —N(R 3 )—, etc., or a salt thereof.

  本发明提供了一种用于治疗血栓症的环酰胺衍生物，其化学式表示为(I)：其中，R1代表可选取代的环烃基或可选取代的杂环基，W代表键或可选取代的双价链烃基，a代表0、1或2，X1代表可选取代的较低烷基烯基或可选取代的较低烷基，Y1代表—C（O）—、—S（O）—或—S（O）2—，A代表可进一步取代的哌嗪环或可进一步取代的吡啶环，X2代表键或可选取代的较低烷基，Y2代表—C（O）—、—S（O）—、—S（O）2—或—C（═NR7）—，X3代表可选取代的C1-4烷基或可选取代的C2-4烯基，Z3代表—N（R4）—、—O—或键，Z1代表—C（R2）（R2′）—、—N（R2）—等，Z2代表—C（R3）（R3′）—、—N（R3）—等，或其盐。
• CYCLIC AMIDE DERIVATIVE, AND ITS PRODUCTION AND USE
  申请人：KUBO Keiji

  公开号：US20100160629A1

  公开（公告）日：2010-06-24

  The present invention provides a cyclic amide derivative useful as a drug for treating thrombosis, which is represented by the formula (I): wherein R 1 represents an optionally substituted cyclic hydrocarbon group or an optionally substituted heterocyclic group, W represents a bond or an optionally substituted divalent chain hydrocarbon group, a represents 0, 1, or 2, X 1 represents an optionally substituted lower alkylene or an optionally substituted lower alkenylene, Y 1 represents —C(O)—, —S(O)— or —S(O) 2 —, A represents a piperazine ring which may be further substituted or a piperidine ring which may be further substituted, X 2 represents a bond or an optionally substituted lower alkylene, Y 2 represents —C(O)—, —S(O)—, —S(O) 2 — or —C(═NR 7 )—, X 3 represents an optionally substituted C 1-4 alkylene or an optionally substituted C 2-4 alkenylene, Z 3 represents —N(R 4 )—, —O— or a bond, Z 1 represents —C(R 2 )(R 2′ )—, —N(R 2 )—, etc., and Z 2 represents —C(R 3 )(R 3′ )—, —N(R 3 )—, etc., or a salt thereof.

  本发明提供了一种环酰胺衍生物，可用作治疗血栓症的药物，其化学式为(I)，其中R1代表可选取代的环烃基或可选取代的杂环基，W代表键或可选取代的二价链烃基，a代表0、1或2，X1代表可选取代的较低烷基或可选取代的较低烯基，Y1代表—C(O)—、—S(O)—或—S(O)2—，A代表可能进一步取代的哌嗪环或可能进一步取代的哌啶环，X2代表键或可选取代的较低烷基，Y2代表—C(O)—、—S(O)—、—S(O)2—或—C(═NR7)—，X3代表可选取代的C1-4烷基或可选取代的C2-4烯基，Z3代表—N(R4)—、—O—或键，Z1代表—C(R2)(R2′)—、—N(R2)—等，Z2代表—C(R3)(R3′)—、—N(R3)—等，或其盐。