4-[7-(3-chloro-4-fluoro-phenylamino)-thiazolo[4,5-d]pyrimidin-2-ylamino]-N,N-bis-(2-methoxy-ethyl)-benzenesulfonamide | 925243-21-6

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 4-[7-(3-chloro-4-fluoro-phenylamino)-thiazolo[4,5-d]pyrimidin-2-ylamino]-N,N-bis-(2-methoxy-ethyl)-benzenesulfonamide
• 英文别名: 4-[7-(3-chloro-4-fluoro-anilino)-thiazolo[4,5-d]pyrimidin-2-ylamino]-N,N-bis-(2-methoxy-ethyl)-benzenesulfonamide；4-(7-(3-chloro-4-fluorophenylamino)thiazolo[4,5-d]pyrimidin-2-ylamino)-N,N-bis(2-methoxyethyl)benzenesulfonamide；4-[[7-(3-chloro-4-fluoroanilino)-[1,3]thiazolo[4,5-d]pyrimidin-2-yl]amino]-N,N-bis(2-methoxyethyl)benzenesulfonamide
• CAS: 925243-21-6
• 化学式: C₂₃H₂₄ClFN₆O₄S₂
• 分子量: 567.065
• InChiKey: AMIDDZHJRZVVOK-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.3
• 重原子数：
  37
• 可旋转键数：
  12
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.26
• 拓扑面积：
  155
• 氢给体数：
  2
• 氢受体数：
  12

反应信息

• 作为产物：
  描述：

  4-amino-N,N-bis-(2-methoxy-ethyl)-benzenesulfonamide 、 以 溶剂黄146 为溶剂， 反应 4.0h， 生成 4-[7-(3-chloro-4-fluoro-phenylamino)-thiazolo[4,5-d]pyrimidin-2-ylamino]-N,N-bis-(2-methoxy-ethyl)-benzenesulfonamide
  参考文献：
  名称：

  Synthesis and evaluation of 2,7-diamino-thiazolo[4,5-d] pyrimidine analogues as anti-tumor epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors

  摘要：

  2,7-Diamino-thiazolo[4,5-d]pyrimidine analogues were synthesized as novel epidermal growth factor receptor ( EGFR) tyrosine kinase inhibitors. Representative compounds showed potent and selective EGFR inhibitory activities and inhibited in vitro cellular proliferation in EGFR-overexpressing human tumor cells. The synthesis and preliminary biological, physical, and pharmacokinetic evaluation of these thiazolopyrimidine compounds are reported. (C) 2009 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2009.02.067

文献信息

• Thiazolopyrimidine kinase inhibitors
  申请人：Binnun Eva

  公开号：US20070185139A1

  公开（公告）日：2007-08-09

  The present invention is directed to novel thiazolopyrimidine compounds of Formula (I) or a form or composition thereof and the thereof as inhibitors of ATP-protein kinase interactions.

  本发明涉及公式（I）的新型噻唑嘧啶化合物，或其形式或组合物，以及它们作为ATP-蛋白激酶相互作用抑制剂的应用。
• US7605154B2
  申请人：——

  公开号：US7605154B2

  公开（公告）日：2009-10-20