1-phenylmethyl-3-methoxy-4,4-dimethoxypiperidine | 156971-33-4

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 1-phenylmethyl-3-methoxy-4,4-dimethoxypiperidine
• 英文别名: 3,4,4-trimethoxy-1-(phenylmethyl)piperidine；1-benzyl-3,4,4-trimethoxypiperidine
• CAS: 156971-33-4
• 化学式: C₁₅H₂₃NO₃
• 分子量: 265.353
• InChiKey: RWFKRLDCHCONFX-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.5
• 重原子数：
  19
• 可旋转键数：
  5
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.6
• 拓扑面积：
  30.9
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  1-phenylmethyl-3-methoxy-4,4-dimethoxypiperidine 在 硫酸 、 sodium carbonate 作用下， 以28.8 parts (98.6%)的产率得到3-methoxy-1-(phenylmethyl)-4-piperidinone
  参考文献：
  名称：

  Novel N-(3-hydroxy-4-piperidinyl)benzamide derivatives

  摘要：

  新型N-(3-羟基-4-哌啶基)苯甲酰胺及其衍生物，所述化合物可用作促进胃肠系统运动的刺激剂。

  公开号：

  US04962115A1
• 作为产物：
  描述：

  1-benzyl-4,4-dimethoxypiperidin-3-ol 、 碘甲烷 在 sodium hydride 作用下， 以 DMF (N,N-dimethyl-formamide) 为溶剂， 生成 1-phenylmethyl-3-methoxy-4,4-dimethoxypiperidine
  参考文献：
  名称：

  [EN] STEREOISOMERIC COMPOUNDS AND METHODS FOR THE TREATMENT OF GASTROINTESTINAL AND CENTRAL NERVOUS SYSTEM DISORDERS
  [FR] COMPOSES STEREO-ISOMERES ET METHODES DE TRAITEMENT DE TROUBLES GASTRO-INTESTINAUX ET DU SYSTEME NERVEUX CENTRAL

  摘要：

  本发明提供了式（X）的立体异构化合物：其中变量如本文所定义，并提供了用于安全有效治疗各种胃肠道疾病的组合物，包括但不限于胃轻瘫、胃食管反流及相关症状。本发明的化合物还可用于治疗涉及中枢神经系统的各种疾病。

  公开号：

  WO2005068461A1

文献信息

• N-aryl-N-(1-substituted-3-alkoxy-4-piperidinyl)amides and pharmaceutical
  申请人：BOC, Inc.

  公开号：US04994471A1

  公开（公告）日：1991-02-19

  This invention pertains to novel N-aryl-N-[N-substituted 3-alkoxy-4-piperidinyl]amides useful as analgesics, and methods of administering analgesia, which comprises the systemic administration to mammals of such compounds, and pharmaceutical compositions containing such compounds, wherein the novel compounds have the general formula: ##STR1## including optically active isomeric forms, cis/trans isomeric forms and the pharmaceutically acceptable acid addition salts therof, wherein: R is an aryl group selected from the group consisting of phenyl and substituted phenyl, wherein the substituents on the phenyl group are independently selected from the group consisting of halogen, lower-alkyl, lower-alkoxy, and combinations thereof; R.sub.1 is an alkyl group selected from the group consisting of lower-alkyl, lower-alkenyl, and lower-alkoxy lower-alkyl, each alkyl group having from 1 to 6 carbon atoms; R.sub.2 is a member selected from the group consisting of phenyl lower-alkyl, thienyl lower-alkyl, pyrazolyl lower-alkyl, tetrazolyl lower-alkyl, 4,5-dihydro-5-oxo-1H-tetrazolyl lower-alkyl, 1,3-dihydro-1,3-dioxo-2H-isoindolyl lower-alkyl, and 2,3-dihydro-2-oxo-1H-benzimidazolyl lower-alkyl; and R.sub.3 is a member selected from the group consisting of hydrogen, lower-alkyl and lower-alkyl aryl.

  本发明涉及一种新型的N-芳基-N-[N-取代3-烷氧基-4-哌啶基]酰胺，用作镇痛剂，以及给哺乳动物系统性地给予这种化合物的镇痛方法和含有这种化合物的制药组合物，其中这种新型化合物具有以下通式：##STR1## 包括光学活性异构体形式，顺反异构体形式和其药学上可接受的酸加成盐，其中：R是从苯基和取代苯基组成的群体中选择的芳基基团，其中苯基上的取代基是独立地从卤素、低烷基、低烷氧基和它们的组合中选择的；R.sub.1是从低烷基、低烯基和低烷氧基低烷基组成的群体中选择的烷基基团，每个烷基含有1至6个碳原子；R.sub.2是从苯基低烷基、噻吩基低烷基、吡唑基低烷基、四唑基低烷基、4,5-二氢-5-氧代-1H-四唑基低烷基、1,3-二氢-1,3-二氧代-2H-异吲哚基低烷基和2,3-二氢-2-氧代-1H-苯并咪唑基低烷基中选择的成员；以及R.sub.3是从氢、低烷基和低烷基芳基中选择的成员。
• Novel N-(3-hydroxy-4-piperidinyl) benzamide derivatives
  申请人：Janssen Pharmaceutica N.V.

  公开号：US05057525A1

  公开（公告）日：1991-10-15

  Novel N-(3-hydroxy-4-pipridinyl)benzamides and derivatives thereof, said compounds being used as stimulators of the motility of the gastro-intestinal system.

  小说N-(3-羟基-4-哌啶基)苯甲酰胺及其衍生物，所述化合物被用作胃肠系统运动的刺激剂。
• N-aryl-n-(1-substituted-3-alkoxy-4-piperidinyl)amides and pharmaceutical
  申请人：Anaquest, Inc.

  公开号：US05100903A1

  公开（公告）日：1992-03-31

  This invention pertains to novel N-aryl-N-[N-substituted 3-alkoxy-4-piperidinyl]amides useful as analgesics, and methods of administering analgesia, which comprises the systemic administration to mammals of such compounds, and pharmaceutical compositions containing such compounds, wherein the novel compounds have the general formula: ##STR1## including optically active isomeric forms, cis/trans isomeric forms and the pharmaceutically acceptable acid addition salts thereof, wherein: R is an aryl group selected from the group consisting of phenyl and substituted phenyl, wherein the substituents on the phenyl group are independently selected from the group consisting of halogen, lower-alkyl, lower-alkoxy, and combinations thereof; R.sub.1 is an alkyl group selected from the group consisting of lower-alkyl, lower-alkenyl, and lower-alkoxy lower-alkyl, each alkyl group having from 1 to 6 carbon atoms; R.sub.2 is a member selected from the group consisting of phenyl lower-alkyl, thienyl lower-alkyl, pyrazolyl lower-alkyl, tetrazolyl lower-alkyl, 4,5-dihydro-5-oxo-1H-tetrazolyl lower-alkyl, 1,3-dihydro-1,3-dioxo-2H-isoindolyl lower-alkyl, and 2,3-dihydro-2-oxo-1H-benzimidazolyl lower-alkyl; and R.sub.3 is a member selected from the group consisting of hydrogen, lower-alkyl and lower-alkyl aryl.

  本发明涉及一种新型N-芳基-N-[N-取代的3-烷氧基-4-哌啶基]酰胺，作为镇痛剂使用，以及镇痛剂的给药方法，包括将这些化合物系统地给哺乳动物进行静脉注射，以及含有这些化合物的制药组合物。其中，这些新型化合物具有以下通式：##STR1##包括对映异构体形式、顺反异构体形式和药学上可接受的酸加成盐。其中：R是选自苯基和取代苯基的芳基基团，其中苯基上的取代基独立地选自卤素、低碳基、低氧基和其组合；R.sub.1是选自低碳基、低烯基和低氧基低碳基的烷基基团，每个烷基基团具有1至6个碳原子；R.sub.2是选自苯基低碳基、噻吩基低碳基、吡唑基低碳基、四唑基低碳基、4,5-二氢-5-氧代-1H-四唑基低碳基、1,3-二氢-1,3-二酮-2H-异吲哚基低碳基和2,3-二氢-2-氧代-1H-苯并咪唑基低碳基的成员；R.sub.3是选自氢、低碳基和低碳基芳基的成员。
• N-(3-hydroxy-4-piperidinyl)benzamide derivatives
  申请人：Janssen Pharmaceutica N.V.

  公开号：US05137896A1

  公开（公告）日：1992-08-11

  Novel N-(3-hydroxy-4-piperidinyl)benzamides and derivatives thereof, said compounds being useful as stimulators of the motility of the gastro-intestinal system.

  小说N-(3-羟基-4-哌啶基)苯甲酰胺及其衍生物，这些化合物可用作胃肠道系统的运动促进剂。
• Synthetic Methods and Intermediates for Stereoisomeric Compounds Useful for the Treatment of Gastrointestinal and Central Nervous System Disorders
  申请人：By Kolbot

  公开号：US20070078265A1

  公开（公告）日：2007-04-05

  The subject invention provides methods and/or processes for making stereoisomeric compounds of formula (X): wherein the variables are as defined herein, and compositions for the safe and effective treatment of various gastrointestinal disorders including, but not limited to, gastroparesis, gastroesophageal reflux and related conditions. The compounds of the subject invention are also useful in treating a variety of conditions involving the central nervous system.

  本发明提供了制备式（X）立体异构化合物的方法和/或过程，其中变量如本文所定义，并提供用于安全有效治疗各种胃肠道疾病的组合物，包括但不限于胃轻瘫，胃食管反流和相关疾病。本发明的化合物还可用于治疗涉及中枢神经系统的各种疾病。