α-cyclopropyl-4-chlorophenylacetyl chloride | 74222-28-9

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: α-cyclopropyl-4-chlorophenylacetyl chloride
• 英文别名: α-cyclopropyl-4-chlorophenyl-acetic acid chloride；alpha-Cyclopropyl-4-chlorophenylacetyl chloride；2-(4-chlorophenyl)-2-cyclopropylacetyl chloride
• CAS: 74222-28-9
• 化学式: C₁₁H₁₀Cl₂O
• 分子量: 229.106
• InChiKey: WSIKXRMSSKPGHA-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.1
• 重原子数：
  14
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.36
• 拓扑面积：
  17.1
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  α-cyclopropyl-4-chlorophenylacetyl chloride 在 镍 吡啶 、 盐酸羟胺 、 氢气 作用下， 以 乙醚 、 乙醇 为溶剂， 100.0 ℃ 、8.0 MPa 条件下， 反应 12.0h， 生成 [1-Amino-2-(4-chloro-phenyl)-2-cyclopropyl-ethyl]-phosphonic acid diethyl ester
  参考文献：
  名称：

  Maier, Ludwig; Diel, Peter J., Phosphorus, Sulfur and Silicon and the Related Elements, 1991, vol. 62, # 1.4, p. 15 - 28

  摘要：

  DOI：

文献信息

• Combating arthropods with fluorine-containing phenylacetic acid esters
  申请人：Bayer Aktiengesellschaft

  公开号：US04405639A1

  公开（公告）日：1983-09-20

  Fluorine-containing phenylacetic acid esters of the formula ##STR1## in which R represents the radical of an alcohol customary in the case of pyrethroids, R.sup.1 represents C.sub.2-4 -alkyl, C.sub.2-4 -alkenyl or cyclopropyl, X represents H, halogen, alkyl, alkoxy, OCHF.sub.2, SCHF.sub.2, SCClF.sub.2 or SCF.sub.3 and X.sup.1 can vary widely or form a fused ring with X, the overall compound necessarily containing a fluorine atom, which compounds possess arthropodicidal properties. Intermediates therefor and an overall synthesis from an alcohol of the formula ROH and a toluene of the formula ##STR2## are also shown.

  化学式为##STR1##的含氟苯乙酸酯，其中R代表在拟除虫剂中通常使用的醇基团，R.sup.1代表C.sub.2-4-烷基，C.sub.2-4-烯基或环丙基，X代表H，卤素，烷基，烷氧基，OCHF.sub.2，SCHF.sub.2，SCClF.sub.2或SCF.sub.3，X.sup.1可以广泛变化或与X形成融合环，整个化合物必须含有氟原子，这些化合物具有杀虫性能。还显示了其中间体和从公式为ROH的醇和公式为##STR2##的甲苯中的总合成。
• Pesticidal 3-phenoxybenzyl .alpha.-cyclopropyl .alpha.-phenyl-acetates
  申请人：Ciba-Geigy Corporation

  公开号：US04264624A1

  公开（公告）日：1981-04-28

  .alpha.-Phenyl-.alpha.-cyclopropylacetates of the formula ##STR1## wherein X.sub.1 represents hydrogen, halogen or C.sub.1 -C.sub.4 alkyl, X.sub.2 represents hydrogen, methyl or halogen, R.sub.1 represents hydrogen, cyano, vinyl or ethynyl, and Y represents fluorine or bromine, processes for their manufacture, and a method of controlling pests which comprises the use of these novel esters.

  本发明提供了化学式为##STR1##的.alpha.-苯基-.alpha.-环丙基乙酸酯，其中X.sub.1代表氢、卤素或C.sub.1-C.sub.4烷基，X.sub.2代表氢、甲基或卤素，R.sub.1代表氢、氰基、乙烯基或乙炔基，而Y代表氟或溴，以及制造这些新型酯的方法和利用这些新型酯进行害虫控制的方法。
• Insecticidal cyclopropyl-substituted di(aryl) compounds
  申请人：FMC Corporation

  公开号：US04808762A1

  公开（公告）日：1989-02-28

  Compounds of the formula ##STR1## in which Ar is substituted or unsubstituted phenyl, naphthyl, or thienyl; Z is oxygen, sulfur, or methylene; and Ar' is 2-methyl[1,1'-biphenyl]-3-yl, 3-phenoxyphenyl, 4-fluoro-3-phenoxyphenyl, or 6-phenoxy-2-pyridyl exhibit pyrethroid-like insecticidal and acaricidal activity and are relatively harmless to aquatic fauna.

  式子为##STR1##的化合物，其中Ar是取代或未取代的苯基，萘基或噻吩基；Z是氧，硫或亚甲基；而Ar'是2-甲基[1,1'-联苯]-3-基，3-苯氧基苯基，4-氟-3-苯氧基苯基或6-苯氧基-2-吡啶基，展现类似拟除虫菊酯的杀虫和杀螨活性，并且对水生动物相对无害。
• Combating arthropods with novel fluorine-containing phenylacetic acid
  申请人：Bayer Aktiengesellschaft

  公开号：US04284643A1

  公开（公告）日：1981-08-18

  Fluorine-containing phenylacetic acid esters of the formula ##STR1## in which R represents the radical of an alcohol customary in the case of pyrethroids, R.sup.1 represents C.sub.2-4 -alkyl, C.sub.2-4 -alkenyl or cyclopropyl, X represents H, halogen, alkyl, alkoxy, OCHF.sub.2, SCHF.sub.2, SCClF.sub.2 or SCF.sub.3 and X.sup.1 can vary widely or form a fused ring with X, the overall compound necessarily containing a fluorine atom, which compounds possess arthropodicidal properties. Intermediates therefor and an overall synthesis from an alcohol of the formula ROH and a toluene of the formula ##STR2## are also shown.

  含氟苯乙酸酯的化学式为##STR1##，其中R代表在拟除虫剂中惯用的醇基团，R.sup.1代表C.sub.2-4-烷基，C.sub.2-4-烯基或环丙基，X代表H、卤素、烷基、烷氧基、OCHF.sub.2、SCHF.sub.2、SCClF.sub.2或SCF.sub.3，X.sup.1可以广泛变化或与X形成融合环，整体化合物必然含有氟原子，这些化合物具有杀虫作用。还显示了中间体以及从化学式ROH的醇和化学式##STR2##的甲苯的整体合成方法。
• Intermediates and derivatives thereof
  申请人：Bayer Aktiengesellschaft

  公开号：US04348323A1

  公开（公告）日：1982-09-07

  Fluorine-containing phenylacetic acid esters of the formula ##STR1## in which R represents the radical of an alcohol customary in the case of pyrethroids, R.sup.1 represents C.sub.2-4 -alkyl, C.sub.2-4 -alkenyl or cyclopropyl, X represents H, halogen, alkyl, alkoxy, OCHF.sub.2, SCHF.sub.2, SCClF.sub.2 or SCF.sub.3 and X.sup.1 can vary widely or form a fused ring with X, the overall compound necessarily containing a fluorine atom, which compounds possess arthropodicidal properties. Intermediates therefor and an overall synthesis from an alcohol of the formula ROH and a toluene of the formula ##STR2## are also shown.

  公式为##STR1##的含氟苯乙酸酯，其中R代表在拟除虫剂中惯用的醇基团，R.sup.1代表C.sub.2-4-烷基，C.sub.2-4-烯基或环丙基，X代表H，卤素，烷基，烷氧基，OCHF.sub.2，SCHF.sub.2，SCClF.sub.2或SCF.sub.3，X.sup.1可以广泛变化或与X形成融合环，整个化合物必然含有氟原子，这些化合物具有杀虫作用。还显示了其中间体及从公式为ROH的醇和公式为##STR2##的甲苯总合成。