2,3-二乙基吡啶 | 103039-56-1

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 中文名称: 2,3-二乙基吡啶
• 中文别名: 螺环[4.5] dec-7-ene-1-羧醛，4,8-二甲基-，(4R)-(9CI)
• 英文名称: 2,3-diethylpyridine
• 英文别名: 2,3-Diethyl-pyridin；diethylpyridine
• CAS: 103039-56-1
• 化学式: C₉H₁₃N
• 分子量: 135.209
• InChiKey: YXZUDXLWSOZHFN-UHFFFAOYSA-N

物化性质

• 沸点：
  187.6±9.0 °C(Predicted)
• 密度：
  0.911±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2.5
• 重原子数：
  10
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.44
• 拓扑面积：
  12.9
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为产物：
  描述：

  3-己炔 、 丙烯胺 在 六氟磷酸钾 、 [ruthenium(II)(η⁶-1-methyl-4-isopropyl-benzene)(chloride)(μ-chloride)]₂ 、 copper diacetate 作用下， 以 甲醇 为溶剂， 反应 24.0h， 生成 2,3-二乙基吡啶
  参考文献：
  名称：

  Primary Amines as Directing Groups in the Ru-Catalyzed Synthesis of Isoquinolines, Benzoisoquinolines, and Thienopyridines

  摘要：

  Isoquinolines, benzoisoquinolines, thieno[3,2-c]pyridines and fused heteroaryl[2,3-c] pyridines, with a wide variety of substituents at different positions of the aromatic or heteroaromatic rings, have been synthesized by Ru-catalyzed oxidative coupling of a broad range of benzylamines or heterocycles with internal alkynes. All benzylamines and heterocycles have unprotected primary amines as efficient directing groups.

  DOI：

  10.1021/jo400344m

文献信息

• [EN] TLR7/8 ANTAGONISTS AND USES THEREOF<br/>[FR] ANTAGONISTES DE TLR7/8 ET LEURS UTILISATIONS
  申请人：MERCK PATENT GMBH

  公开号：WO2018031434A1

  公开（公告）日：2018-02-15

  The present invention relates to compounds of Formula I and pharmaceutically acceptable compositions thereof, useful as TLR7/8 antagonists.

  本发明涉及式I化合物及其药用可接受的组合物，用作TLR7/8拮抗剂。
• Linear urea mimics antagonists of P2Y1 receptor useful in the treatment of thrombotic condition
  申请人：Chao J. Hannguang

  公开号：US20070004677A1

  公开（公告）日：2007-01-04

  The present invention provides novel urea mimics and analogues of Formula (I): or a stereoisomer, tautomer, pharmaceutically acceptable salt or solvate form thereof, wherein the variables A, B, W, and R 6 are as defined herein. These compounds are selective inhibitors of the human P2Y 1 receptor which can be used as medicaments.

  本发明提供了新颖的尿素类似物和类似物，其化学式为（I）：或其立体异构体、互变异构体、药学上可接受的盐或溶剂形式，其中变量A、B、W和R6如本文所定义。这些化合物是人类P2Y1受体的选择性抑制剂，可用作药物。
• BISPHOSPHONATE COMPOUNDS
  申请人：Ebetino Frank Hallock

  公开号：US20110098251A1

  公开（公告）日：2011-04-28

  Novel bisphosphonate cyclic acetal compounds are disclosed, as well as methods of preparing the compounds, pharmaceutical compositions including the compounds, and administration of the compounds in methods of treating bone metabolism disorders, such as abnormal calcium and phosphate metabolism.

  揭示了一种新型的双膦酸环缩醛化合物，以及制备这些化合物的方法，包括这些化合物的药物组合物，以及在治疗骨代谢紊乱的方法中给予这些化合物的方法，例如异常的钙和磷代谢。
• Organic Compounds
  申请人：Schilling Boris

  公开号：US20100113460A1

  公开（公告）日：2010-05-06

  Disclosed are compounds having the ability to inhibit cytochrome P450 2A6, 2A13, and/or 2B6 and tobacco products comprising them. Also disclosed are pharmaceutical compositions comprising them.

  揭示了一种具有抑制细胞色素P450 2A6、2A13和/或2B6能力的化合物，以及包含它们的烟草产品。还披露了包含这些化合物的药物组合物。
• Inhibitors of cell proliferation, angiogenesis, fertility, and muscle contraction
  申请人：——

  公开号：US20030064989A1

  公开（公告）日：2003-04-03

  The invention concerns inhibitors of cell proliferation, angiogenesis, fertility, and muscle contraction, characterized by formula I 1 wherein, X, Y and Z independently represent C or N; ------ is an optional double bond; n is 0 or 1; R 1 , R 2 , and R 4 independently represent hydrogen, a chemical bond, C 1-10 alkyl; C 2-10 alkenyl; C 2-10 alkinyl; aryl; aryl-C 1-10 alkyl; C 3-10 heterocyclyl; C 5-10 heteroaryl; halo, CF 3 ; NO 2 ; NHC(O)R*, OR, said alkyl, alkenyl, alkinyl, aryl, arylalkyl, heterocyclyl, or heteroaryl being optionally substituted; R 3 , R 5 , and R 6 independently represent hydrogen, C 1-10 alkyl; C 2-10 alkenyl; C 2-10 alkinyl; aryl; aryl-C 1-10 alkyl; C 3-10 heterocyclyl; C 5-10 heteroaryl; halo, CF 3 ; NO 2 ; NHC(O)R*, OR, said alkyl, alkenyl, alkinyl, aryl, heterocyclyl, or heteroaryl being optionally substituted; or R 5 and R 6 together form a 5- or 6-member aryl, heterocyclyl or heteroaryl group; R is hydrogen or C 1-6 alkyl; R* is hydrogen, or C 1-6 alkyl, or OH, wherein the optional substituents are preferably selected from the group of one to three OH, C 1-6 alkyl, halo, NO 2 , C 1-6 alkoxy, and CF3, or a pharmaceutically acceptable salt thereof.

  该发明涉及细胞增殖、血管生成、生育和肌肉收缩的抑制剂，其特征在于以下公式I1： 其中，X、Y和Z独立表示C或N；------是一个可选的双键；n为0或1；R1、R2和R4独立表示氢、化学键、C1-10烷基；C2-10烯基；C2-10炔基；芳基；芳基-C1-10烷基；C3-10杂环烷基；C5-10杂芳基；卤素、三氟甲基；NO2；NHC(O)R*、OR，所述的烷基、烯基、炔基、芳基、芳基烷基、杂环烷基或杂芳基可以是可选的取代基；R3、R5和R6独立表示氢、C1-10烷基；C2-10烯基；C2-10炔基；芳基；芳基-C1-10烷基；C3-10杂环烷基；C5-10杂芳基；卤素、三氟甲基；NO2；NHC(O)R*、OR，所述的烷基、烯基、炔基、芳基、芳基烷基、杂环烷基或杂芳基可以是可选的取代基；或者R5和R6一起形成一个5-或6-成员的芳基、杂环烷基或杂芳基；R为氢或C1-6烷基；R*为氢、或C1-6烷基、或OH，其中可选的取代基优选从一个到三个OH、C1-6烷基、卤素、NO2、C1-6烷氧基和三氟甲基中选择，或其药学上可接受的盐。