1,6-dimethoxy-2-isopropylnaphthalene | 62416-10-8

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 英文名称: 1,6-dimethoxy-2-isopropylnaphthalene
• 英文别名: 1,6-dimethoxy-2-propan-2-ylnaphthalene
• CAS: 62416-10-8
• 化学式: C₁₅H₁₈O₂
• 分子量: 230.307
• InChiKey: NBTVOLBGQBXMOK-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.2
• 重原子数：
  17
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  18.5
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  1-Hydroxy-6-methoxy-naphthalene-2-carboxylic acid ethyl ester 在 caesium carbonate 、 对甲苯磺酸 作用下， 以 乙醚 、 甲苯 为溶剂， 反应 26.0h， 生成 1,6-dimethoxy-2-isopropylnaphthalene
  参考文献：
  名称：

  Synthesis of Some Substituted Naphthalenes as Potential Intermediates for Polyethers and Terpenoids

  摘要：

  1-Benzyloxy-5-hydroxynaphthalene and 1,6-dimethyl-5-hydroxynaphthalene were prepared from 5-methoxy-alpha-tetralone. 6-Methoxy-alpha-tetralone was converted to 1,6-dimethoxy-2-isopropylnaphthalene.

  DOI：

  10.1023/b:rugc.0000018662.02489.8d

文献信息

• HU, SHENG-YU, ACTA CHIM. SIN., 45,(1987) N 5, 506-509
  作者：HU, SHENG-YU

  DOI：——

  日期：——
• 11-Beta hydroxysteroid dehydrogenase type 1 inhibitors as anti-obesity/anti-diabetes compounds and 17-beta hydrosteroid dehydrogenase type I inhibitors as useful agents for the treatment of cancers, especially breast cancer
  申请人：Vander Jagt L. David

  公开号：US20050228038A1

  公开（公告）日：2005-10-13

  This invention is directed to the discovery that 11-Beta Hydroxysteroid Dehydrogenase Type 1 may be a common molecular etiology for visceral obesity and the metabolic syndrome of obesity as well a treatment for diabetes, especially type II diabetes. The present invention also relates to the use of certain compounds as inhibitors of 17-Beta Hydroxysteroid Dehydrogenase Type 1 and their use for the treatment of cancer, especially breast cancer.
• Synthesis of Some Substituted Naphthalenes as Potential Intermediates for Polyethers and Terpenoids
  作者：A. K. Banerjee、P. S. Poon、M. S. Laya、J. A. Azocar

  DOI：10.1023/b:rugc.0000018662.02489.8d

  日期：2003.11

  1-Benzyloxy-5-hydroxynaphthalene and 1,6-dimethyl-5-hydroxynaphthalene were prepared from 5-methoxy-alpha-tetralone. 6-Methoxy-alpha-tetralone was converted to 1,6-dimethoxy-2-isopropylnaphthalene.