N-[1-S(-)-phenylpropyl]-N-isobutylamine | 704913-10-0

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: N-[1-S(-)-phenylpropyl]-N-isobutylamine
• 英文别名: 2-methyl-N-[(1S)-1-phenylpropyl]propan-1-amine
• CAS: 704913-10-0
• 化学式: C₁₃H₂₁N
• 分子量: 191.316
• InChiKey: CHKAGFZILMAFOC-ZDUSSCGKSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.5
• 重原子数：
  14
• 可旋转键数：
  5
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.54
• 拓扑面积：
  12
• 氢给体数：
  1
• 氢受体数：
  1

反应信息

• 作为产物：
  描述：

  在 1% Pd/C 氢气 作用下， 以 异丙醇 为溶剂， 生成 N-[1-S(-)-phenylpropyl]-N-isobutylamine
  参考文献：
  名称：

  EP1577294

  摘要：

  公开号：

文献信息

• <scp>l</scp>-Valine derived chiral N-sulfinamides as effective organocatalysts for the asymmetric hydrosilylation of N-alkyl and N-aryl protected ketimines
  作者：Chao Wang、Xinjun Wu、Li Zhou、Jian Sun

  DOI：10.1039/c4ob01257g

  日期：——

  L-Valine derived N-sulfinamides have been developed as efficient enantioselective Lewis basic organocatalysts for the asymmetric reduction of N-aryl and N-alkyl ketimines with trichlorosilane. Catalyst 3c afforded up to 99% yield and 96% ee in the reduction of N-alkyl ketimines and up to 98% yield and 98% ee in the reduction of N-aryl ketimines.

  已经开发出L-缬氨酸衍生的N-亚磺酰胺作为有效的对映选择性路易斯碱性有机催化剂，用于用三氯硅烷不对称还原N-芳基和N-烷基酮亚胺。催化剂3c在N-烷基酮亚胺的还原中提供高达99％的收率和96％ee，在N-芳基酮亚胺的还原中提供高达98％的收率和98％ee 。
• S-SUBSTITUTED N-1- (HETERO)ARYL ALKYL-N - (HETERO)ARYL ALKYLYSOTHIOCARBAMIDES, METHOD FOR THE PRODUCTION THEREOF, PHYSIOLOGICALLY ACTIVE S-SUBSTITUTED N-1- (HETERO )ARYL ALKYL-N - (HETERO)ARYL ALKYLYSOTHIOCARBAMIDES,A PHARMACEUTICAL COMPOUND AND CURING METHOD
  申请人：Institut Fiziologicheski Aktivnykh Veschestv Rossiyskov Akademii Nauk

  公开号：EP1577294A1

  公开（公告）日：2005-09-21

  The invention relates to s-substituted N-1-[(hetero)aryl]alkyl-N-1-[(hetero)aryl]alkylysothio-carbamides and the physiologically active salts and bases thereof, embodied in the form of racemic mixtures (or stereoisomer mixture) or individual optical isomers. The specific physiological activity of said compounds makes it possible to use them in the form of molecular tools. Said invention also relates to Pharmaceutical compositions, containing said compounds and to a method for preventing and curing various diseases including neurodegenerative diseases as, for example Alzheimer's disease (AD). The pharmacological effect of said compounds is based on the combined cognitive-stimulating and neuroprotective action thereof, which is produced by acting on chemo-controlled calcium channels of neurone membranes, in particular the neurones regulated by glutamate receptors of the central neural system (CNS).

  本发明涉及 s-取代的 N-1-[(杂)芳基]烷基-N-1-[(杂)芳基]烷基硫代氨基甲酸酯及其具有生理活性的盐和碱，以外消旋混合物（或立体异构体混合物）或单个光学异构体的形式体现。上述化合物的特殊生理活性使其有可能以分子工具的形式使用。本发明还涉及含有上述化合物的药物组合物，以及预防和治疗各种疾病（包括神经退行性疾病，如阿尔茨海默病（AD））的方法。所述化合物的药理作用基于其刺激认知和保护神经的综合作用，这种作用是通过作用于神经元膜的化学控制钙通道产生的，特别是受中枢神经系统（CNS）谷氨酸受体调节的神经元。