2,3-Pyrazinedione, 1,4-dihydro-1-(1-methylethyl)- | 92716-39-7

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪类
• 英文名称: 2,3-Pyrazinedione, 1,4-dihydro-1-(1-methylethyl)-
• 英文别名: 4-propan-2-yl-1H-pyrazine-2,3-dione
• CAS: 92716-39-7
• 化学式: C₇H₁₀N₂O₂
• 分子量: 154.17
• InChiKey: TXZXBDHQIUALAS-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0
• 重原子数：
  11
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.43
• 拓扑面积：
  49.4
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  N-(2,2-diethoxyethyl)-N'-propan-2-yloxamide 生成 2,3-Pyrazinedione, 1,4-dihydro-1-(1-methylethyl)-
  参考文献：
  名称：

  SADAKI, HIROSHI;IMAIZUMI, HIROYUKI;NAGAI, TAKASHI;TAKEDA, KENJI;MYOKAN, I+

  摘要：

  DOI：

文献信息

• [EN] METHODS OF PREPARING FACTOR XA INHIBITORS AND SALTS THEREOF<br/>[FR] PROCÉDÉS DE PRÉPARATION D'INHIBITEURS DU FACTEUR XA ET DE LEURS SELS
  申请人：MILLENNIUM PHARM INC

  公开号：WO2011075602A1

  公开（公告）日：2011-06-23

  The present invention provides for methods of preparing compounds of Formula I or a salt of the compound or a hydrate of the compound or salt thereof that are factor Xa inhibitors. Specifically the present invention provides a method of preparing the compound 5-chloro-N-((1-(4-(2-oxopyridin-1(2H)-yl)phenyl)-1H-imidazol-4-yl)methyl)thiophene-2-carboxamide, or a salt of the compound or a hydrate of the compound or salt thereof.

  本发明提供了制备式I化合物或其盐或其水合物或其盐的方法，这些化合物是Xa因子抑制剂。具体而言，本发明提供了制备化合物5-氯-N-((1-(4-(2-氧代吡啶-1(2H)-基)苯基)-1H-咪唑-4-基)甲基)噻吩-2-羧酰胺，或其盐或其水合物或其盐的方法。
• FACTOR Xa INHIBITORS
  申请人：Zhu Bing-Yan

  公开号：US20070185092A1

  公开（公告）日：2007-08-09

  The present invention is directed to compounds represented by Formula (I) or a pharmaceutically acceptable salt, ester, or prodrug thereof which are inhibitors of Factor Xa. The present invention is also directed to and intermediates used in making such compounds, pharmaceutical compositions containing such compounds, methods to prevent or treat a number of conditions characterized by undesired thrombosis and methods of inhibiting the coagulation of a blood sample.

  本发明涉及由式（I）表示的化合物，或其药学上可接受的盐、酯或前药，其是因子Xa的抑制剂。本发明还涉及用于制备这种化合物的中间体，含有这种化合物的制药组合物，用于预防或治疗由不良血栓形成所表征的多种疾病的方法，以及抑制血液样品凝血的方法。
• FACTOR XA INHIBITORS
  申请人：Zhu Bing-Yan

  公开号：US20100234352A1

  公开（公告）日：2010-09-16

  The present invention is directed to compounds represented by Formula (I) or a pharmaceutically acceptable salt, ester, or prodrug thereof which are inhibitors of Factor Xa. The present invention is also directed to and intermediates used in making such compounds, pharmaceutical compositions containing such compounds, methods to prevent or treat a number of conditions characterized by undesired thrombosis and methods of inhibiting the coagulation of a blood sample.

  本发明涉及由式（I）表示的化合物或其药学上可接受的盐、酯或前药，其为因子Xa的抑制剂。本发明还涉及制备这些化合物所使用的中间体，含有这些化合物的药物组合物，预防或治疗一些以不需要的血栓形成为特征的疾病的方法，以及抑制血样的凝血方法。
• SADAKI, HIROSHI;IMAIZUMI, HIROYUKI;NAGAI, TAKASHI;TAKEDA, KENJI;MYOKAN, I+
  作者：SADAKI, HIROSHI、IMAIZUMI, HIROYUKI、NAGAI, TAKASHI、TAKEDA, KENJI、MYOKAN, I+

  DOI：——

  日期：——
• US7696352B2
  申请人：——

  公开号：US7696352B2

  公开（公告）日：2010-04-13