2,4,α-Trimethylphenylhydrazin | 90565-16-5

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2,4,α-Trimethylphenylhydrazin
• 英文别名: Dimethyl-p-toluidine amine；1-(2,4-dimethylphenyl)-1-methylhydrazine
• CAS: 90565-16-5
• 化学式: C₉H₁₄N₂
• 分子量: 150.224
• InChiKey: JROJMNVZOCKYJI-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2
• 重原子数：
  11
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  29.3
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  苯丙炔酸甲酯 、 2,4,α-Trimethylphenylhydrazin 在 copper(I) oxide 、 caesium carbonate 作用下， 以 甲苯 为溶剂， 以60 %的产率得到methyl 1-(2,4-dimethylphenyl)-3-phenyl-1H-pyrazole-4-carboxylate
  参考文献：
  名称：

  N,N-二取代肼与炔酸酯的铜促进有氧氧化 [3+2] 环加成反应：获得取代吡唑

  摘要：

  开发了铜促进的有氧氧化 [3+2] 环加成反应，用于在碱存在下从 N,N-二取代肼与炔酸酯合成各种取代吡唑。这项工作涉及直接 C(sp 3 )–H 功能化和新 C–C/C–N 键的形成。在该策略中，廉价易得的Cu 2 O作为促进剂，空气作为绿色氧化剂。该反应具有原子和步骤经济性高、区域选择性高、操作简单等优点。

  DOI：

  10.1021/acs.joc.2c02610

文献信息

• Metal-Free Temperature-Controlled Intermolecular [3 + 2] Annulation to Access Benzo[<i>d</i>]thiazole-2(3<i>H</i>)-thiones and Benzo[<i>d</i>]thiazol-2(3<i>H</i>)-ones
  作者：Xiaoya Zhuo、Lvyin Zheng、Xiaoying Zou、Yumei Zhong、Wei Guo

  DOI：10.1021/acs.joc.2c01060

  日期：2022.8.5

  A facile access to benzo[d]thiazole-2(3H)-thiones and benzo[d]thiazol-2(3H)-ones has been developed through a temperature-controlled intermolecular [3 + 2] annulation of N,N-disubstituted arylhydrazines with CS2 in the presence of DMSO. This protocol can obviate the prefunctionalization of the starting materials. This direct C–S/C–N bond formation reaction was performed in the absence of any external

  通过温度控制的 N,N 分子间 [3 + 2] 环化，开发了一种容易获得苯并[ d ]噻唑-2(3 H )-硫酮和苯并[ d ]噻唑-2(3 H )-酮的方法-在DMSO存在下用CS 2二取代的芳基肼。该协议可以避免起始材料的预功能化。这种直接的 C-S/C-N 键形成反应是在没有任何外部催化剂、过渡金属、碱、配体和氧化剂的情况下进行的，具有高步骤经济性。
• Visible Light-Enhanced [3 + 2] Cycloaddition of <i>N</i>,<i>N</i>-Disubstituted Hydrazines with Organo-Cyanamides: Access to Polysubstituted 1,2,4-Triazol-3-amines
  作者：Xiaoya Zhuo、Lvyin Zheng、Yujie Liu、Yihan Wang、Xiaoying Zou、Yumei Zhong、Wei Guo

  DOI：10.1021/acs.joc.3c02085

  日期：2024.1.19

  light-enhanced [3 + 2] cycloaddition of N,N-disubstituted hydrazines with N-cyano-N-aryl-p-toluenesulfonamides is an efficient reaction pathway to polysubstituted 1,2,4-triazol-3-amines. The reaction is performed under mild conditions without the addition of any transition metals. This strategy involves a C(sp3)–H bond activation, a cyano cycloaddition, and the formation of two new C═N bonds. The protocol

  N , N-二取代肼与N-氰基-N-芳基-对甲苯磺酰胺的可见光增强[3 + 2]环加成是生成多取代1,2,4-三唑-3-胺的有效反应途径。该反应在温和条件下进行，不添加任何过渡金属。该策略涉及 C(sp 3 )–H 键激活、氰基环加成以及两个新 C=N 键的形成。该方案显示出良好的官能团耐受性和广泛的底物范围的优点。后期修饰实验为有机合成和药物化学领域提供了实际应用。
• Expandable and curable polyester composition and method for making same
  申请人：UNIROYAL, INC.

  公开号：EP0083173A1

  公开（公告）日：1983-07-06

  An expandable and curable polyester composition comprising a mixture of a liquid, ethylenically unsaturated polyester resin composition; a peroxide; an organometallic promotor; and a dialkyl or trialkyl hydrazine is disclosed. In addition, a method for forming said expanded and cured polyester resin composition, and the product formed in accordance with said method, an expanded and cured polyester resin composition, is taught.

  本发明公开了一种可膨胀固化的聚酯组合物，该组合物包含一种液态乙烯基不饱和聚酯树脂组合物、一种过氧化物、一种有机金属促进剂和一种二烷基或三烷基肼的混合物。 此外，还教导了一种形成所述膨胀固化聚酯树脂组合物的方法，以及根据所述方法形成的产品--膨胀固化聚酯树脂组合物。
• Water compatible nanogel compositions
  申请人：The Regents of the University of Colorado

  公开号：US10829672B2

  公开（公告）日：2020-11-10

  The present invention relates to preparation and use of water dispersible nanogels and solvent dispersible reactive nanogels as additives to enhance polymer properties or as precursors to polymeric networks.

  本发明涉及水分散性纳米凝胶和溶剂分散性活性纳米凝胶的制备和使用，可用作增强聚合物性能的添加剂或聚合物网络的前体。
• Control of polymer network structures via nanogels
  申请人：THE REGENTS OF THE UNIVERSITY OF COLORADO, A BODY CORPORATE

  公开号：US10968300B2

  公开（公告）日：2021-04-06

  A method of increasing a polymerization reaction rate of a base monomer composition that has slow free-radical polymerization kinetics. The method comprises combining an effective amount of a nanogel to the base monomer composition to form a monomer-nanogel mixture having a polymerization reaction rate that is greater than the polymerization reaction rate of the base monomer composition when subjected to an identical free-radical polymerization reaction conducted under identical conditions. The base monomer composition comprises one or more slow-kinetic monomers with slow free radical polymerization kinetics in which <25% of the double bonds are converted within the first 10 mintes of said reaction. The nanogel is soluble in the base monomer composition. The nanogel is derived from a nanogel-forming monomer mixture that comprises: at least one monovinyl monomer; at least one divinyl monomer; a chain transfer agent; and an initiator.

  一种提高具有缓慢自由基聚合动力学的基础单体组合物聚合反应速率的方法。该方法包括将有效量的纳米凝胶与基础单体组合物结合，形成单体-纳米凝胶混合物，该混合物在相同条件下进行相同的自由基聚合反应时，其聚合反应速率大于基础单体组合物的聚合反应速率。基础单体组合物包括一种或多种具有缓慢自由基聚合动力学的慢动力学单体，在所述反应的前 10 分钟内，小于 25% 的双键被转化。纳米凝胶可溶于基础单体组合物。纳米凝胶来自纳米凝胶形成单体混合物，该混合物包括：至少一种单乙烯基单体；至少一种二乙烯基单体；链转移剂和引发剂。