2-phenylcarbamoyl-3-methyl-5,6-dihydro-imidazo [2,1-b] thiazole hydrochloride | 84950-67-4

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2-phenylcarbamoyl-3-methyl-5,6-dihydro-imidazo [2,1-b] thiazole hydrochloride
• 英文别名: 3-methyl-N-phenyl-5,6-dihydroimidazo[2,1-b][1,3]thiazole-2-carboxamide;hydrochloride
• CAS: 84950-67-4
• 化学式: C₁₃H₁₃N₃OS*ClH
• 分子量: 295.793
• InChiKey: BKTPVDOKCFXVII-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.7
• 重原子数：
  19
• 可旋转键数：
  2
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.23
• 拓扑面积：
  70
• 氢给体数：
  2
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  2-phenylcarbamoyl-3-methyl-5,6-dihydro-imidazo [2,1-b] thiazole hydrochloride 生成 2-phenylcarbamoyl-3-methyl-5,6-dihydro-imidazo [2,1-b] thiazole
  参考文献：
  名称：

  摘要：

  DOI：
• 作为产物：
  描述：

  2-氯乙酰乙酰替苯胺 、 亚乙基硫脲 生成 2-phenylcarbamoyl-3-methyl-5,6-dihydro-imidazo [2,1-b] thiazole hydrochloride
  参考文献：
  名称：

  摘要：

  DOI：

文献信息

• 2,-3-Di-substituted-5,6-dihydroimidazo [2,1-b] thiazole, its salts,
  申请人：Kumiai Kagaku Kogyo Kabushiki Kaisha

  公开号：US04556669A1

  公开（公告）日：1985-12-03

  Compounds of the formula ##STR1## wherein R is ##STR2## in which R.sub.1, R.sub.2 and R.sub.3 are the same or different and are selected from the group consisting of hydrogen, chlorine, bromine, lower alkyl, lower alkoxy and naphthyl, provided that when R.sub.1 is lower alkyl, R.sub.2 and R.sub.3 are hydrogen, chlorine, bromine or lower alkoxy, or a pharmaceutically acceptable salt thereof, have anti-carrageenin edema activity, and are useful as anti-inflammatory agents and immuno modulators. They are produced by reacting an amide of the formula ##STR3## wherein R has the same meanings hereinabove, with N,N'-ethylene thiourea.

  化合物的公式为##STR1##其中R为##STR2##其中R.sub.1，R.sub.2和R.sub.3相同或不同，选择自氢，氯，溴，较低烷基，较低烷氧基和萘基的群，前提是当R.sub.1为较低烷基时，R.sub.2和R.sub.3为氢，氯，溴或较低烷氧基，或其药学上可接受的盐，具有抗卡拉胶水肿活性，并可用作抗炎剂和免疫调节剂。它们通过将公式为##STR3##的酰胺与N，N'-乙硫脲反应而制得，其中R具有上述相同的含义。
• 2,3-di-substituted-5,6-dihydroimidazo [2,1-b] thiazole, its salts,
  申请人：Toyo Jozo Kabushiki Kaisha

  公开号：US04629793A1

  公开（公告）日：1986-12-16

  Compounds of the formula wherein R is ##STR1## in which R.sub.1, R.sub.2 and R.sub.3 are the same or different and are selected from the group consisting of hydrogen, chlorine, bromine, lower alkyl, lower alkoxy and naphthyl, provided that when R.sub.1 is lower alkyl, R.sub.2 and R.sub.3 are hydrogen, chlorine, bromine or lower alkoxy, or a pharmaceutically acceptable salt thereof, have anti-carrageenin edema activity, and are useful as anti-inflammatory agents and immuno modulators. They are produced by reacting an amide of the formula ##STR2## wherein R has the same meanings hereinabove, with N,N'-ethylene thiourea.

  该化合物的公式为其中R为##STR1##其中R.sub.1、R.sub.2和R.sub.3相同或不同，选择自氢、氯、溴、较低的烷基、较低的烷氧基和萘基的群体，前提是当R.sub.1为较低的烷基时，R.sub.2和R.sub.3为氢、氯、溴或较低的烷氧基，或其药学上可接受的盐，具有抗海藻酸钠水肿活性，并且可用作抗炎剂和免疫调节剂。它们通过将该式的酰胺与N，N'-乙硫脲反应而制得，其中R具有上述相同的含义。
• ——
  作者：NISHIO KAZUO、 CHIYOMARU ISAO、 ANMA KATSUO、 YAMAMOTO KAZUKO、 OHNO HIROSHI、+

  DOI：——

  日期：——