N-(pyridin-3-ylmethyl)pyrazin-2-amine | 1039822-07-5

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪类
• 英文名称: N-(pyridin-3-ylmethyl)pyrazin-2-amine
• 英文别名: pz-3-py
• CAS: 1039822-07-5
• 化学式: C₁₀H₁₀N₄
• mdl: MFCD11125677
• 分子量: 186.216
• InChiKey: RUZDAKAFHAYCMM-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.5
• 重原子数：
  14
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.1
• 拓扑面积：
  50.7
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  N-(pyridin-3-ylmethyl)pyrazin-2-amine 、 mercury dibromide 以 甲醇 为溶剂， 以45%的产率得到[Hg(μ-N-(pyridin-3-ylmethyl)pyrazin-2-amine)Br2]
  参考文献：
  名称：

  Anion-Directed Self-Assembly in Coordination Networks: Architectural Control via Cooperative Noncovalent Interactions

  摘要：

  The self-assembly of a new flexible tritopic pyrazine-pyridine ligand (pz-3-py) with HgX2 (X = Cl, Br) was investigated. The results show that coordinated chloride and bromide anions play different roles, and two architecturally different coordination polymers were obtained with the anions used. Where X = Cl, in [Hg(mu(3)-pz-3-py)Cl-2](n) (1), the 2D network is isolated, while for X = Br, in [Hg(mu-pz-3-py)Br-2](n) (2), a 1D zigzag chain is constructed. Our results show that noncovalent interactions such as hydrogen bond, halogen center dot center dot center dot halogen, and halogen center dot center dot center dot pi interactions, when acting cooperatively, are driving forces for the selection of different structures.

  DOI：

  10.1021/ic101387c
• 作为产物：
  描述：

  3-吡啶甲醛 、 氨基吡嗪 在 甲酸 作用下， 以 乙醇 为溶剂， 反应 12.0h， 以3.8 g的产率得到N-(pyridin-3-ylmethyl)pyrazin-2-amine
  参考文献：
  名称：

  Anion-Directed Self-Assembly in Coordination Networks: Architectural Control via Cooperative Noncovalent Interactions

  摘要：

  The self-assembly of a new flexible tritopic pyrazine-pyridine ligand (pz-3-py) with HgX2 (X = Cl, Br) was investigated. The results show that coordinated chloride and bromide anions play different roles, and two architecturally different coordination polymers were obtained with the anions used. Where X = Cl, in [Hg(mu(3)-pz-3-py)Cl-2](n) (1), the 2D network is isolated, while for X = Br, in [Hg(mu-pz-3-py)Br-2](n) (2), a 1D zigzag chain is constructed. Our results show that noncovalent interactions such as hydrogen bond, halogen center dot center dot center dot halogen, and halogen center dot center dot center dot pi interactions, when acting cooperatively, are driving forces for the selection of different structures.

  DOI：

  10.1021/ic101387c

文献信息

• [EN] DIARYLAMINE-SUBSTITUTED QUINOLONES USEFUL AS INDUCIBLE NITRIC OXIDE SYNTHASE INHIBITORS<br/>[FR] QUINOLONES SUBSTITUÉES PAR DIARYLAMINE UTILES COMME INHIBITEURS DE L'OXYDE NITRIQUE SYNTHASE INDUCTIBLE.
  申请人：KALYPSYS INC

  公开号：WO2009029617A1

  公开（公告）日：2009-03-05

  Novel diarylamine-substituted quinolone compounds and pharmaceutical compositions, certain of which have been found to inhibit inducible NOS synthase have been discovered, together with methods of synthesizing and using the compounds including methods for the treatment of iNOS-mediated diseases in a patient by administering the compounds.

  已发现新的含有二芳胺基取代喹诺酮化合物和药物组合物，其中一些已被发现能抑制诱导型NOS合成酶，还包括合成和使用这些化合物的方法，包括通过给患者施用这些化合物治疗iNOS介导的疾病的方法。
• Anion-Directed Self-Assembly in Coordination Networks: Architectural Control <i>via</i> Cooperative Noncovalent Interactions
  作者：Behrouz Notash、Nasser Safari、Hamid Reza Khavasi

  DOI：10.1021/ic101387c

  日期：2010.12.20

  The self-assembly of a new flexible tritopic pyrazine-pyridine ligand (pz-3-py) with HgX2 (X = Cl, Br) was investigated. The results show that coordinated chloride and bromide anions play different roles, and two architecturally different coordination polymers were obtained with the anions used. Where X = Cl, in [Hg(mu(3)-pz-3-py)Cl-2](n) (1), the 2D network is isolated, while for X = Br, in [Hg(mu-pz-3-py)Br-2](n) (2), a 1D zigzag chain is constructed. Our results show that noncovalent interactions such as hydrogen bond, halogen center dot center dot center dot halogen, and halogen center dot center dot center dot pi interactions, when acting cooperatively, are driving forces for the selection of different structures.