4-Hydrazino-2,5,6-trimethylpyrimidin | 69142-13-8

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪类
• 英文名称: 4-Hydrazino-2,5,6-trimethylpyrimidin
• 英文别名: 6-Hydrazino-2,4,5-trimethyl-pyrimidin；4-hydrazino-2,5,6-trimethyl-pyrimidine；(2,5,6-Trimethylpyrimidin-4-yl)hydrazine
• CAS: 69142-13-8
• 化学式: C₇H₁₂N₄
• 分子量: 152.199
• InChiKey: HTKHJZSTGGGADW-UHFFFAOYSA-N

物化性质

• 熔点：
  164-166 °C
• 沸点：
  265.5±23.0 °C(Predicted)
• 密度：
  1.21±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  0.9
• 重原子数：
  11
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.43
• 拓扑面积：
  63.8
• 氢给体数：
  2
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  4-Hydrazino-2,5,6-trimethylpyrimidin 、 原甲酸三乙酯 以50%的产率得到
  参考文献：
  名称：

  BROWN D. J.; NAGAMATSU T., AUSTRAL. J. CHEM., 1978, 31, NO 11, 2505-2515

  摘要：

  DOI：

文献信息

• PYRIMIDINE DERIVATIVES AND METHODS OF TREATMENT RELATED TO THE USE THEREOF
  申请人：TAISHO PHARMACEUTICAL CO., LTD

  公开号：EP1730122A2

  公开（公告）日：2006-12-13
• US7919528B2
  申请人：——

  公开号：US7919528B2

  公开（公告）日：2011-04-05
• [EN] PYRIMIDINE DERIVATIVES AND METHODS OF TREATMENT RELATED TO THE USE THEREOF<br/>[FR] DERIVES DE PYRIMIDINE ET PROCEDES DE TRAITEMENT LIES A L'UTILISATION DE CEUX-CI
  申请人：TAISHO PHARMA CO LTD

  公开号：WO2005095357A2

  公开（公告）日：2005-10-13

  The present invention encompasses novel substituted pyrimidine compounds of Formula (I): which act as MCH receptor antagonists. These compounds are useful in pharmaceutical compositions whose use includes prophylaxis or treatment of improving memory function, sleeping and arousal, anxiety, depression, mood disorders, seizure, obesity, diabetes, appetite and eating disorders, cardiovascular disease, hypertension, dyslipidemia, myocardial infarction, binge eating disorders including bulimia, anorexia, mental disorders including manic depression, schizophrenia, delirium, dementia, stress, cognitive disorders, attention deficit disorder, substance abuse disorders and dyskinesias including Parkinson’s disease, epilepsy, and addiction.