N-Methyl-6-[[1-(4-methylphenyl)-2-(-3-thienyl)-1H-benzimidazol-6-yl]oxy]hexanamide | 582310-56-3

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并咪唑类
• 英文名称: N-Methyl-6-[[1-(4-methylphenyl)-2-(-3-thienyl)-1H-benzimidazol-6-yl]oxy]hexanamide
• 英文别名: N-methyl-6-[3-(4-methylphenyl)-2-thiophen-3-ylbenzimidazol-5-yl]oxyhexanamide
• CAS: 582310-56-3
• 化学式: C₂₅H₂₇N₃O₂S
• 分子量: 433.574
• InChiKey: AJECLOOJMMUAPX-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.1
• 重原子数：
  31
• 可旋转键数：
  9
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.28
• 拓扑面积：
  84.4
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  6-[[1-(4-methylphenyl)-2-(thien-3-yl)-1H-benzimidazol-6-yl]oxy]hexanoic acid methyl ester 、 盐酸甲胺 生成 N-Methyl-6-[[1-(4-methylphenyl)-2-(-3-thienyl)-1H-benzimidazol-6-yl]oxy]hexanamide
  参考文献：
  名称：

  1-Phenyl-2-heteroaryl-substituted benzimdazole derivatives, their use for the production of pharmaceutical agents as well as pharmaceutical preparations that contain these derivatives

  摘要：

  本文介绍了新的苯并咪唑衍生物，它们的制备方法以及它们用于生产用于治疗和预防与微神经胶质细胞活化和T细胞介导的免疫性疾病相关的药物，以及含有新的苯并咪唑衍生物的制药制剂。

  公开号：

  US20030229085A1

文献信息

• 1-Phenyl-2-heteroaryl-substituted benzimidazole derivatives, their use for the production of pharmaceutical agents as well as pharmaceutical preparations that contain these derivatives
  申请人：Blume Thorsten

  公开号：US20050267160A1

  公开（公告）日：2005-12-01

  New benzimidazole derivatives are described, their production and their use for the production of pharmaceutical agents for treatment and prevention of diseases that are associated with a microglia activation and T-cell-mediated immunological diseases, as well as pharmaceutical preparations that contain the new benzimidazole derivatives.

  本文描述了新的苯并咪唑衍生物，它们的生产以及它们用于制备与微胶质细胞激活和T细胞介导的免疫性疾病有关的药物治疗和预防疾病的用途，以及包含新的苯并咪唑衍生物的制药制剂。
• US6962932B2
  申请人：——

  公开号：US6962932B2

  公开（公告）日：2005-11-08
• US7683081B2
  申请人：——

  公开号：US7683081B2

  公开（公告）日：2010-03-23
• 1-Phenyl-2-heteroaryl-substituted benzimdazole derivatives, their use for the production of pharmaceutical agents as well as pharmaceutical preparations that contain these derivatives
  申请人：Schering Aktiengesellschaft

  公开号：US20030229085A1

  公开（公告）日：2003-12-11

  New benzimidazole derivatives are described, their production and their use for the production of pharmaceutical agents for treatment and prevention of diseases that are associated with a microglia activation and T-cell-mediated immunological diseases, as well as pharmaceutical preparations that contain the new benzimidazole derivatives.

  本文介绍了新的苯并咪唑衍生物，它们的制备方法以及它们用于生产用于治疗和预防与微神经胶质细胞活化和T细胞介导的免疫性疾病相关的药物，以及含有新的苯并咪唑衍生物的制药制剂。