5-氰基-N-[2,5-二(1-哌啶基)苯基]-2-糠酰胺 | 959626-45-0

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 中文名称: 5-氰基-N-[2,5-二(1-哌啶基)苯基]-2-糠酰胺
• 英文名称: 5-Cyano-N-(2,5-di(piperidin-1-yl)phenyl)furan-2-carboxamide
• 英文别名: cFMS Receptor Inhibitor IV；5-cyano-N-[2,5-di(piperidin-1-yl)phenyl]furan-2-carboxamide
• CAS: 959626-45-0
• 化学式: C₂₂H₂₆N₄O₂
• 分子量: 378.474
• InChiKey: FQGXFVDABCBEFW-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.1
• 重原子数：
  28
• 可旋转键数：
  4
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.45
• 拓扑面积：
  72.5
• 氢给体数：
  1
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  5-cyanofuran-2-carbonyl chloride 、 2,5-di(piperidin-1-yl)aniline 在 PS-morpholine 作用下， 以 1,4-二氧六环 为溶剂， 反应 2.0h， 生成 5-氰基-N-[2,5-二(1-哌啶基)苯基]-2-糠酰胺
  参考文献：
  名称：

  Potent 2′-aminoanilide inhibitors of cFMS as potential anti-inflammatory agents

  摘要：

  A series of 2 '-aminoanilides have been identified which exhibit potent and selective inhibitory activity against the cFMS tyrosine kinase. Initial SAR studies within this series are described which examine aroyl and amino group substitutions, as well as the introduction of hydrophilic substituents on the benzene core. Compound 47 inhibits the isolated enzyme (IC50 = 0.027 mu M) and blocks CSF-1-induced proliferation of bone marrow-derived macrophages (IC50 = 0.11 mu M) and as such, serves as a lead candidate for further optimization studies. (C) 2007 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2007.09.057

文献信息

• Compositions and methods for obtaining enriched mesenchymal stem cell cultures
  申请人：StemCell Technologies Inc.

  公开号：US10017741B2

  公开（公告）日：2018-07-10

  The disclosure provides a method of culturing cells of the mesenchymal cell lineage, said method comprising contacting the cells with a culture media comprising a CSF1R kinase inhibitor. The disclosure also provides a method of culturing cells from bone marrow and/or compact bone to enrich the cells with cells of the mesenchymal cell lineage comprising contacting the cells with a culture media comprising a CSF1R kinase inhibitor. Cell culture media comprising a CSF1R kinase inhibitor and useful for culturing cells of the mesenchymal cell lineage and/or enriching cells of the mesenchymal cell lineage is also provided.

  本发明提供了一种培养间充质细胞系细胞的方法，所述方法包括使细胞与含有CSF1R激酶抑制剂的培养基接触。本公开还提供了一种从骨髓和/或紧密骨中培养细胞以富集间充质细胞系细胞的方法，该方法包括使细胞与包含CSF1R激酶抑制剂的培养基接触。本发明还提供了含有CSF1R激酶抑制剂的细胞培养基，可用于培养间充质细胞系细胞和/或富集间充质细胞系细胞。
• COMPOSITIONS AND METHODS FOR OBTAINING ENRICHED MESENCHYMAL STEM CELL CULTURES
  申请人：Stemcell Technologies Inc.

  公开号：EP2970905A1

  公开（公告）日：2016-01-20
• COMBINATIONS OF AGENTS TO TREAT HEMATOLOGICAL MALIGNANCIES
  申请人：Oregon Health & Science University

  公开号：US20200054639A1

  公开（公告）日：2020-02-20

  Methods of treating acute myeloid leukemia, chronic lymphocytic leukemia and myeloproliferative neoplasms that involve the administration of combinations of small molecule compounds are disclosed.
• [EN] COMPOSITIONS AND METHODS FOR OBTAINING ENRICHED MESENCHYMAL STEM CELL CULTURES<br/>[FR] COMPOSITIONS ET PROCÉDÉS POUR OBTENIR DES CULTURES DE CELLULES SOUCHES MÉSENCHYMATEUSES ENRICHIES
  申请人：STEMCELL TECHNOLOGIES INC

  公开号：WO2014138888A1

  公开（公告）日：2014-09-18

  The disclosure provides a method of culturing cells of the mesenchymal cell lineage, said method comprising contacting the cells with a culture media comprising a CSF1R kinase inhibitor. The disclosure also provides a method of culturing cells from bone marrow and/or compact bone to enrich the cells with cells of the mesenchymal cell lineage comprising contacting the cells with a culture media comprising a CSF1R kinase inhibitor. Cell culture media comprising a CSF1R kinase inhibitor and useful for culturing cells of the mesenchymal cell lineage and/or enriching cells of the mesenchymal cell lineage is also provided.
• Potent 2′-aminoanilide inhibitors of cFMS as potential anti-inflammatory agents
  作者：Raymond J. Patch、Benjamin M. Brandt、Davoud Asgari、Nand Baindur、Naresh K. Chadha、Taxiarchis Georgiadis、Wing S. Cheung、Ioanna P. Petrounia、Robert R. Donatelli、Margery A. Chaikin、Mark R. Player

  DOI：10.1016/j.bmcl.2007.09.057

  日期：2007.11

  A series of 2 '-aminoanilides have been identified which exhibit potent and selective inhibitory activity against the cFMS tyrosine kinase. Initial SAR studies within this series are described which examine aroyl and amino group substitutions, as well as the introduction of hydrophilic substituents on the benzene core. Compound 47 inhibits the isolated enzyme (IC50 = 0.027 mu M) and blocks CSF-1-induced proliferation of bone marrow-derived macrophages (IC50 = 0.11 mu M) and as such, serves as a lead candidate for further optimization studies. (C) 2007 Elsevier Ltd. All rights reserved.