(Z)-9,10-hexadecene-1,16-dioic acid | 253687-18-2

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: (Z)-9,10-hexadecene-1,16-dioic acid
• 英文别名: cis-7-hexadecene dioic acid；7-Hexadecenedioic acid, (7Z)-；(Z)-hexadec-7-enedioic acid
• CAS: 253687-18-2
• 化学式: C₁₆H₂₈O₄
• 分子量: 284.396
• InChiKey: NJNZHDLLCUGGBQ-IWQZZHSRSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.4
• 重原子数：
  20
• 可旋转键数：
  14
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.75
• 拓扑面积：
  74.6
• 氢给体数：
  2
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  (Z)-9,10-epithiohexadecane-1,16-dioic acid 在 碘 作用下， 以 苯 为溶剂， 以0.34 g的产率得到(Z)-9,10-hexadecene-1,16-dioic acid
  参考文献：
  名称：

  Majee; Yadav, Journal of the Indian Chemical Society, 2004, vol. 81, # 3, p. 261 - 263

  摘要：

  DOI：

文献信息

• Cosmetic composition containing retinol and dioic acid
  申请人：Unilever Patent Holdings B.V.

  公开号：US05705144A1

  公开（公告）日：1998-01-06

  A composition for topical application to human skin in order to promote the repair of photo-damaged skin and/or to reduce or prevent the damaging effects of ultra-violet light on skin and/or to lighten the skin comprising retinol or a derivative thereof and a dioic acid.

  一种用于局部涂抹于人类皮肤上以促进修复光损伤皮肤和/或减少或预防紫外线对皮肤的损害作用和/或美白皮肤的组合物，包括视黄醇或其衍生物和二羧酸。
• Therapeutic compositions comprising unsaturated dioic acids or
  申请人：Unichema Chemie B.V.

  公开号：US05753704A1

  公开（公告）日：1998-05-19

  Disclosed are certain novel polyunsaturated dioic acids having between 8 and 16 carbon atoms (inclusive), excluding those compounds in the group consisting of: 2,5 octadienedioic acid; 1,7 octadienedioic acid; 2,4,6 octatrienedioic acid; and 1,3,5,7 nonatetraenedioic acid; 2,5,8 decatrienedioic acid; 3,6 dodecadienedioic acid; 3,13 hexadecadienedioic acid. Also disclosed are pharmaceutical or cosmetic compositions comprising unsaturated dioic acids and certain of their derivatives. Also disclosed are methods of treating human skin and a method of preparing unsaturated dioic acids.

  本发明涉及一些新型的多不饱和二羧酸，其碳数在8至16之间（包括8和16），但不包括以下化合物组合：2,5-辛二烯二酸；1,7-辛二烯二酸；2,4,6-辛三烯二酸；1,3,5,7-非那四烯二酸；2,5,8-癸三烯二酸；3,6-十二碳二烯二酸；3,13-十六碳二烯二酸。本发明还涉及包含不饱和二羧酸及其某些衍生物的制药或化妆品组合物。本发明还涉及治疗人类皮肤的方法和制备不饱和二羧酸的方法。
• METHOD FOR THE SYNTHESIS OF OMEGA-UNSATURATED FATTY ACIDS
  申请人：Dubois Jean-Luc

  公开号：US20100216198A1

  公开（公告）日：2010-08-26

  The invention relates to a method for the synthesis of short-chain ω-unsaturated fatty acids of general formula CH 2 ═CH—(CH 2 ) n —COOR in which n is an integer between 2 and 11 and R is H or an alkyl radical containing from 1 to 4 carbon atoms, from long-chain monounsaturated fatty acids or esters of formula CH 3 —(CH 2 ) m —CH═CH—(CH 2 ) p —COOR in which m and p are integers, either identical or different, between 2 and 11, such that the molecule contains at least 10 adjacent carbon atoms in the main chain, said method comprises the first step of submitting the long-chain monounsaturated fatty acid charge to an oxidation by fermentation using a microorganism containing enzymes of oxygenase type, thus leading to the formation of α,ω-diacids, and then a second step of subjecting the product from the first step to a catalytic metsthesis crossed with ethylene for forming two short-chain ω-unsaturated fatty acids having a main chain length relative to that of the starting unsaturated fatty acid or ester of between 0.2 and 0.8, and preferably 0.35 and 0.75.

  本发明涉及一种从长链单不饱和脂肪酸或酯合成一般式为CH2═CH—(CH2)n—COOR的短链ω-不饱和脂肪酸的方法，其中n是介于2和11之间的整数，R是H或含有1至4个碳原子的烷基基团，所述长链单不饱和脂肪酸或酯的化学式为CH3—(CH2)m—CH═CH—(CH2)p—COOR，其中m和p是介于2和11之间的整数，可以相同也可以不同，使得分子中至少包含10个相邻的碳原子在主链中，所述方法包括第一步，将长链单不饱和脂肪酸充电进行氧化发酵，使用含有氧化酶类酶的微生物，从而导致α，ω-二酸的形成，然后第二步，将第一步的产物经过催化交叉重合与乙烯反应，形成两种短链ω-不饱和脂肪酸，其主链长度相对于起始不饱和脂肪酸或酯的长度在0.2到0.8之间，优选在0.35到0.75之间。
• BIOLOGICAL METHODS FOR PREPARING A FATTY DICARBOXYLIC ACID
  申请人：Beardslee Tom

  公开号：US20140228586A1

  公开（公告）日：2014-08-14

  The technology relates in part to biological methods for producing a fatty dicarboxylic acid and engineered microorganisms capable of such production.

  该技术部分涉及生物学方法，用于生产脂肪二羧酸和能够进行此类生产的工程微生物。
• Biological methods for modifying cellular carbon flux
  申请人：Radici Chimica S.p.A.

  公开号：US11174488B2

  公开（公告）日：2021-11-16

  The technology relates in part to biological methods for modifying carbon flux in cells, engineered cells and organisms in which cellular carbon flux has been modified, and methods of using engineered cells and organisms for production of organic molecules.

  该技术部分涉及改变细胞中碳通量的生物方法、改变细胞中碳通量的工程细胞和生物体，以及使用工程细胞和生物体生产有机分子的方法。