(2R,3S)-2-Aminomethyl-3-hydroxy-5-oxo-pyrrolidine-1-carboxylic acid tert-butyl ester | 397883-90-8

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡咯烷类
• 英文名称: (2R,3S)-2-Aminomethyl-3-hydroxy-5-oxo-pyrrolidine-1-carboxylic acid tert-butyl ester
• 英文别名: tert-butyl (2R,3S)-2-(aminomethyl)-3-hydroxy-5-oxopyrrolidine-1-carboxylate
• CAS: 397883-90-8
• 化学式: C₁₀H₁₈N₂O₄
• 分子量: 230.264
• InChiKey: HWOLSKMJQWFHRT-RQJHMYQMSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.3
• 重原子数：
  16
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.8
• 拓扑面积：
  92.9
• 氢给体数：
  2
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  (4S,5R)-5-azidomethyl-4-hydroxy-2-oxo-pyrrolidine-1-carboxylic acid tert-butyl ester 在 palladium on activated charcoal 氢气 作用下， 以 甲醇 为溶剂， 反应 44.0h， 生成 (2R,3S)-2-Aminomethyl-3-hydroxy-5-oxo-pyrrolidine-1-carboxylic acid tert-butyl ester
  参考文献：
  名称：

  Stereoselective Formal Synthesis of Pseudodistomin C

  摘要：

  [GRAPHICS]Trisubstituted benzenesulfonylmethylpiperidine 4, in which the substituents are all cis to each other, is a direct synthetic precursor of the cytotoxic marine alkaloid pseudodistomin C; it has been synthesized with total diastereoselectivities from (S)-pyroglutaminol.

  DOI：

  10.1021/ol010221p

文献信息

• Stereoselective Formal Synthesis of Pseudodistomin C
  作者：Nicole Langlois

  DOI：10.1021/ol010221p

  日期：2002.1.1

  [GRAPHICS]Trisubstituted benzenesulfonylmethylpiperidine 4, in which the substituents are all cis to each other, is a direct synthetic precursor of the cytotoxic marine alkaloid pseudodistomin C; it has been synthesized with total diastereoselectivities from (S)-pyroglutaminol.