2-<2,2'-Bipyridyl-(6)>-benzimidazol | 14044-49-6

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 英文名称: 2-<2,2'-Bipyridyl-(6)>-benzimidazol
• 英文别名: 6-(2-benzimidazole)-2,2'-dipyridyl；6-(1H-benzoimidazol-2-yl)-[2,2']bipyridinyl；2-[2,2']bipyridinyl-6-yl-1H-benzoimidazole；2-Benzimidazolyl-6-pyridyl pyridine；2-(6-pyridin-2-ylpyridin-2-yl)-1H-benzimidazole
• CAS: 14044-49-6
• 化学式: C₁₇H₁₂N₄
• 分子量: 272.309
• InChiKey: DOQYIBIQAFPBSG-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.7
• 重原子数：
  21
• 可旋转键数：
  2
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  54.5
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  水合三氯化钌 、 2-<2,2'-Bipyridyl-(6)>-benzimidazol 在 ammonium hexafluorophosphate 作用下， 以 乙醇 、 水 为溶剂， 以38%的产率得到
  参考文献：
  名称：

  Design and investigation of a Ru(II) N-heterocyclic complex which undergoes proton coupled electron transfer

  摘要：

  A novel tridentating ligand containing a single ionizable proton was designed for studying proton coupled electron transfer. The ligand was synthesized by derivatizing 2,2'-bipyridine at the 6-position with benzimidazole (bpy-bzimH), and it was used to prepare the compound [Ru(bpy-bzimH(2)](PF6)(2). Cyclic voltammetry was used to characterize the redox behavior in an aprotic (0.1 M TBAH-CH2Cl2) and protic (1:1 acetonitrile-water buffered solutions) solvent conditions where the latter was employed to characterize the pH-dependence of the Ru(III/II) couple. The redox potential as a function of pH was plotted and reveals a one-proton/one-electron transfer in two separate pH regions (1.39-2.58, and 5.92-7.97), while a two-proton/one-electron process was exhibited between 2.58 and 5.92. (C) 2002 Elsevier Science B.V. All rights reserved.

  DOI：

  10.1016/s0020-1693(01)00667-3
• 作为产物：
  描述：

  、 、 2-(6-bromopyridin-2-yl)-1H-benzo[d]imidazole 、 tributylstannyl radical 、 吡啶 在 钯 作用下， 以to yield 2-benzimidazolyl-6-pyridyl pyridine 6的产率得到2-<2,2'-Bipyridyl-(6)>-benzimidazol
  参考文献：
  名称：

  Polycyclic pyridines as potassium ion channel modulators

  摘要：

  本发明提供了一类多环吡啶，可用作钾离子通道的调节剂。本发明的调节剂在治疗和诊断方法中均有用。

  公开号：

  US07459457B2

文献信息

• POLYCYCLIC PYRIDINES AS POTASSIUM ION CHANNEL MODULATORS
  申请人：Icagen, Inc.

  公开号：EP1742936A2

  公开（公告）日：2007-01-17
• US7459457B2
  申请人：——

  公开号：US7459457B2

  公开（公告）日：2008-12-02
• [EN] POLYCYCLIC PYRIDINES AS POTASSIUM ION CHANNEL MODULATORS<br/>[FR] PYRIDINES POLYCYCLIQUES CONSTITUANT DES MODULATEURS DE CANAUX IONIQUES POTASSIQUES
  申请人：ICAGEN INC

  公开号：WO2005100340A2

  公开（公告）日：2005-10-27

  The present invention provides a genus of polycyclic pyridines that are useful as modulators of potassium ion channels. The modulators of the invention are of use in both therapeutic and diagnostic methods.
• Polycyclic pyridines as potassium ion channel modulators
  申请人：Wang Xiaodong

  公开号：US20050227958A1

  公开（公告）日：2005-10-13

  The present invention provides a genus of polycyclic pyridines that are useful as modulators of potassium ion channels. The modulators of the invention are of use in both therapeutic and diagnostic methods.

  本发明提供了一类多环吡啶，可用作钾离子通道的调节剂。该发明的调节剂在治疗和诊断方法中均有用处。
• Design and investigation of a Ru(II) N-heterocyclic complex which undergoes proton coupled electron transfer
  作者：Tim Ayers、Nicole Caylor、Greg Ayers、Carroll Godwin、David J Hathcock、Valarie Stuman、Spencer J Slattery

  DOI：10.1016/s0020-1693(01)00667-3

  日期：2002.1

  A novel tridentating ligand containing a single ionizable proton was designed for studying proton coupled electron transfer. The ligand was synthesized by derivatizing 2,2'-bipyridine at the 6-position with benzimidazole (bpy-bzimH), and it was used to prepare the compound [Ru(bpy-bzimH(2)](PF6)(2). Cyclic voltammetry was used to characterize the redox behavior in an aprotic (0.1 M TBAH-CH2Cl2) and protic (1:1 acetonitrile-water buffered solutions) solvent conditions where the latter was employed to characterize the pH-dependence of the Ru(III/II) couple. The redox potential as a function of pH was plotted and reveals a one-proton/one-electron transfer in two separate pH regions (1.39-2.58, and 5.92-7.97), while a two-proton/one-electron process was exhibited between 2.58 and 5.92. (C) 2002 Elsevier Science B.V. All rights reserved.