5-Hydroxy-4-phenethylsulfanyl-1-((S)-1-phenyl-ethyl)-pyrrolidin-2-one | 335117-49-2

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 5-Hydroxy-4-phenethylsulfanyl-1-((S)-1-phenyl-ethyl)-pyrrolidin-2-one
• 英文别名: 5-hydroxy-1-[(1S)-1-phenylethyl]-4-(2-phenylethylsulfanyl)pyrrolidin-2-one
• CAS: 335117-49-2
• 化学式: C₂₀H₂₃NO₂S
• 分子量: 341.474
• InChiKey: VNEDXRAQLUOBAD-IJNIYJAUSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.5
• 重原子数：
  24
• 可旋转键数：
  6
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.35
• 拓扑面积：
  65.8
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  5-Hydroxy-4-phenethylsulfanyl-1-((S)-1-phenyl-ethyl)-pyrrolidin-2-one 在 三氟乙酸 作用下， 生成 4-Phenethylsulfanyl-1-((S)-1-phenyl-ethyl)-1,5-dihydro-pyrrol-2-one 、 1-((S)-1-Phenyl-ethyl)-1,5,6,10b-tetrahydro-4-thia-1-aza-benzo[e]azulen-2-one
  参考文献：
  名称：

  Synthesis and reactivity of (1S)-N-(1-phenylethyl)maleimide towards nucleophiles: an application to preparation of chiral pyrroloisothiochroman and pyrrolobenzo[d]thiepine based on π-cationic cyclization

  摘要：

  Chiral pyrroloisothiochroman and pyrrolo[d]thiepine were obtained efficiently in four steps from N-alkylated maleimides via, successively, sulfurization, regioselective reduction followed by pi -cationic cyclination of the N-acyliminium ion intermediates. These latter, in addition, led to conjugate enamides as a consequence of the dehydration reaction. (C) 2001 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0040-4039(00)02037-2
• 作为产物：
  描述：

  (S)-(-)-N-(1-苯基乙基)顺丁烯二酰亚胺 在 sodium tetrahydroborate 、 sodium methylate 作用下， 以 甲醇 、 苯 为溶剂， 反应 12.5h， 生成 5-Hydroxy-4-phenethylsulfanyl-1-((S)-1-phenyl-ethyl)-pyrrolidin-2-one
  参考文献：
  名称：

  Synthesis and reactivity of (1S)-N-(1-phenylethyl)maleimide towards nucleophiles: an application to preparation of chiral pyrroloisothiochroman and pyrrolobenzo[d]thiepine based on π-cationic cyclization

  摘要：

  Chiral pyrroloisothiochroman and pyrrolo[d]thiepine were obtained efficiently in four steps from N-alkylated maleimides via, successively, sulfurization, regioselective reduction followed by pi -cationic cyclination of the N-acyliminium ion intermediates. These latter, in addition, led to conjugate enamides as a consequence of the dehydration reaction. (C) 2001 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0040-4039(00)02037-2

文献信息

• Synthesis and reactivity of (1S)-N-(1-phenylethyl)maleimide towards nucleophiles: an application to preparation of chiral pyrroloisothiochroman and pyrrolobenzo[d]thiepine based on π-cationic cyclization
  作者：Abderrahim Chihab-Eddine、Adam Daı̈ch、Abderrahim Jilale、Bernard Decroix

  DOI：10.1016/s0040-4039(00)02037-2

  日期：2001.1

  Chiral pyrroloisothiochroman and pyrrolo[d]thiepine were obtained efficiently in four steps from N-alkylated maleimides via, successively, sulfurization, regioselective reduction followed by pi -cationic cyclination of the N-acyliminium ion intermediates. These latter, in addition, led to conjugate enamides as a consequence of the dehydration reaction. (C) 2001 Elsevier Science Ltd. All rights reserved.