{6-[3-(4-Trifluoromethyl-benzyloxy)-benzyloxy]-benzo[b]thiophen-3-yl}-acetic acid | 779184-67-7

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: {6-[3-(4-Trifluoromethyl-benzyloxy)-benzyloxy]-benzo[b]thiophen-3-yl}-acetic acid
• 英文别名: {6-[3-(4-Trifluoromethylbenzyloxy)-benzyloxy]-benzo[b]thiophen-3-yl}-acetic acid；2-[6-[[3-[[4-(trifluoromethyl)phenyl]methoxy]phenyl]methoxy]-1-benzothiophen-3-yl]acetic acid
• CAS: 779184-67-7
• 化学式: C₂₅H₁₉F₃O₄S
• 分子量: 472.485
• InChiKey: ULHHEPBMBNXDTI-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.2
• 重原子数：
  33
• 可旋转键数：
  8
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.16
• 拓扑面积：
  84
• 氢给体数：
  1
• 氢受体数：
  8

反应信息

• 作为产物：
  描述：

  {6-[3-(4-Trifluoromethyl-benzyloxy)-benzyloxy]-benzo[b]thiophen-3-yl}-acetic acid methyl ester 、 {7-[4-(4-Chloro-phenyl)-4-oxo-butylsulfanyl]-indan-4-yloxy}-acetic acid 生成 {6-[3-(4-Trifluoromethyl-benzyloxy)-benzyloxy]-benzo[b]thiophen-3-yl}-acetic acid
  参考文献：
  名称：

  Compounds that modulate PPAR activity and methods of preparation

  摘要：

  本发明涉及改变PPAR活性的化合物。本发明还涉及该化合物的药用可接受盐、包含该化合物或其盐的药用可接受组合物以及使用它们作为治疗剂治疗或预防哺乳动物的脂质代谢异常、高胆固醇血症、肥胖症、高血糖症、动脉硬化、高甘油三酯血症和高胰岛素血症的方法。本发明还涉及制备所述化合物的方法。

  公开号：

  US20040209936A1

文献信息

• Compounds that modulate PPAR activity and methods for their preparation
  申请人：Auerbach Bruce J.

  公开号：US06875780B2

  公开（公告）日：2005-04-05

  This invention relates to compounds that alter PPAR activity. The invention also relates to pharmaceutically acceptable salts of the compounds, pharmaceutically acceptable compositions comprising the compounds or their salts, and methods of using them as therapeutic agents for treating or preventing dyslipidemia, hypercholesterolemia, obesity, hyperglycemia, atherosclerosis, hypertriglyceridemia and hyperinsulinemia in a mammal. The present invention also relates to methods for making the disclosed compounds.

  本发明涉及改变PPAR活性的化合物。本发明还涉及所述化合物的药学上可接受的盐、包含所述化合物或其盐的药学上可接受的组合物，以及将它们用作治疗或预防哺乳动物的脂质代谢紊乱、高胆固醇血症、肥胖症、高血糖症、动脉粥样硬化、高甘油三酯血症和高胰岛素血症的治疗剂的方法。本发明还涉及制备所述化合物的方法。
• COMPOUNDS THAT MODULATE PPAR ACTIVITY AND METHODS OF PREPARATION
  申请人：Warner-Lambert Company LLC

  公开号：EP1620086A1

  公开（公告）日：2006-02-01
• US6875780B2
  申请人：——

  公开号：US6875780B2

  公开（公告）日：2005-04-05
• US7244763B2
  申请人：——

  公开号：US7244763B2

  公开（公告）日：2007-07-17
• [EN] COMPOUNDS THAT MODULATE PPAR ACTIVITY AND METHODS OF PREPARATION<br/>[FR] COMPOSES MODULANT DES RECEPTEURS PPAR, ET LEURS PROCEDES DE PREPARATION
  申请人：WARNER LAMBERT CO

  公开号：WO2004091604A1

  公开（公告）日：2004-10-28

  This invention relates to compounds that alter PPAR activity. The invention also relates to pharmaceutically acceptable salts of the compounds, pharmaceutically acceptable compositions comprising the compounds or their salts, and methods of using them as therapeutic agents for treating or preventing dyslipidemia, hypercholesterolemia, obesity, hyperglycemia, atherosclerosis, hypertriglyceridemia and hyperinsulinemia in a mammal. The present invention also relates to methods for making the disclosed compounds.