isosorbide-2-salicylate | 1093683-81-8

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: isosorbide-2-salicylate
• 英文别名: [(3R,3aR,6S,6aR)-3-hydroxy-2,3,3a,5,6,6a-hexahydrofuro[3,2-b]furan-6-yl] 2-hydroxybenzoate
• CAS: 1093683-81-8
• 化学式: C₁₃H₁₄O₆
• 分子量: 266.251
• InChiKey: HEBXZJSNDLMCRQ-WRWGMCAJSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.8
• 重原子数：
  19
• 可旋转键数：
  3
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.46
• 拓扑面积：
  85.2
• 氢给体数：
  2
• 氢受体数：
  6

反应信息

• 作为产物：
  描述：

  isosorbide-2-mononitrate-5-salicylate 在 palladium on activated charcoal 、 氢气 作用下， 以 甲醇 、 乙酸乙酯 为溶剂， 反应 8.0h， 生成 isosorbide-2-salicylate
  参考文献：
  名称：

  发现“真正的”阿司匹林前药。

  摘要：

  通过苯甲酸酯基团的衍生形成的阿司匹林前药非常难以获得，因为该肽原促进了邻近乙酰基团上血浆酯酶的水解速度，从而产生了水杨酸衍生物。通过追踪人血浆溶液中阿司匹林前药异山梨醇-2,5-二氢阿司匹林酸酯（ISDA）的水解模式，我们能够鉴定出代谢物异山梨醇-2-aspirinate-5-salicylate，该代谢物几乎完全转化为阿司匹林人血浆丁酰胆碱酯酶，使其成为迄今为止发现的最成功的阿司匹林前药。

  DOI：

  10.1021/jm801094c

文献信息

• ISOSORBIDE-BASED POLYCARBONATES, METHOD OF MAKING, AND ARTICLES FORMED THEREFROM
  申请人：SABIC Innovative Plastics IP B.V.

  公开号：EP2203501B1

  公开（公告）日：2012-08-15
• UV STABILIZATION OF ISOSORBIDE POLYCARBONATES
  申请人：SABIC Innovative Plastics IP B.V.

  公开号：EP2665775A1

  公开（公告）日：2013-11-27
• ALIPHATIC POLYCARBONATES, METHODS OF MAKING, AND ARTICLES FORMED THEREFROM
  申请人：BRACK Hans-Peter

  公开号：US20090105443A1

  公开（公告）日：2009-04-23

  A method of making a polycarbonate is described. The method comprises melt reacting an ester-substituted diaryl carbonate and a multifunctional compound of the formula: in the presence of catalyst to form an oligomer comprising less than 2,000 ppm of an ester-linked terminal group, and melt polymerizing the oligomer to form a polycarbonate. Use of specific reaction conditions produces a polycarbonate having an Mw of greater than or equal to 25,000 g/mol as determined by gel-permeation chromatography relative to polystyrene standards. Polycarbonates comprising units derived from the multifunctional compound, including homopolycarbonates, aliphatic copolycarbonates further comprising units derived from an aromatic dihydroxy compound, and aliphatic polycarbonate-polyesters, are also disclosed, as are a thermoplastic composition and an article including the disclosed polycarbonates.
• UV Stabilization of Isosorbide Polycarbonates
  申请人：Hurst Jeremy David

  公开号：US20120184651A1

  公开（公告）日：2012-07-19

  Provided herein are polymeric compositions that are suitable protected from UV-induced discoloration and degradation. Such resins comprise an isosorbide polymer and one or more hindered amines. These resin compositions are useful in the manufacture of various shaped, formed and/or molded articles.
• US7666972B2
  申请人：——

  公开号：US7666972B2

  公开（公告）日：2010-02-23