Pyridine-4-carboxaldehyde hydrazone | 51832-68-9

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 英文名称: Pyridine-4-carboxaldehyde hydrazone
• 英文别名: 4-Hydrazonomethyl-pyridin；pyridine-4-carbaldehyde hydrazone；Pyridin-4-carbaldehyd-hydrazon；4-[(Z)-Hydrazinylidenemethyl]pyridine；(E)-pyridin-4-ylmethylidenehydrazine
• CAS: 51832-68-9
• 化学式: C₆H₇N₃
• 分子量: 121.142
• InChiKey: BLEQFIQOCMNEBW-WEVVVXLNSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.4
• 重原子数：
  9
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  51.3
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  Pyridine-4-carboxaldehyde hydrazone 在 盐酸 作用下， 以 乙醇 为溶剂， 反应 0.08h， 以89%的产率得到(1E,2E)-1,2-bis(pyridin-4-ylmethylene)hydrazine
  参考文献：
  名称：

  某些杂志的合成及X射线光电子能谱

  摘要：

  DOI：

  10.1021/je00031a035
• 作为产物：
  描述：

  N'-[1-Pyridin-4-yl-meth-(E)-ylidene]-hydrazinecarboxylic acid ethyl ester 在 一水合肼 作用下， 以 乙醇 为溶剂， 反应 5.0h， 生成 Pyridine-4-carboxaldehyde hydrazone
  参考文献：
  名称：

  某些杂志的合成及X射线光电子能谱

  摘要：

  DOI：

  10.1021/je00031a035

文献信息

• Hydrazide compounds
  申请人：deLong A. Mitchell

  公开号：US20070135499A1

  公开（公告）日：2007-06-14

  Hydrazide compounds with GPCR desensitization inhibitory activity are provided that may be used to influence, inhibit or reduce the action of a G-protein receptor kinase. Pharmaceutical compositions including therapeutically effective amounts of the hydrazide compounds and pharmaceutically acceptable carriers are also provided. Various methods using the compounds and/or compositions to affect disease states or conditions controlled or influenced by GPCRs are also provided. Various methods using the compounds and/or compositions to affect disease states or conditions such as cancer, osteoporosis and glaucoma are also provided.

  提供了具有GPCR脱敏抑制活性的肼基化合物，可用于影响、抑制或减少G蛋白受体激酶的作用。还提供了包括治疗有效量肼基化合物和药用可接受载体的药物组合物。还提供了使用这些化合物和/或组合物影响由GPCR控制或影响的疾病状态或病况的各种方法。还提供了使用这些化合物和/或组合物影响疾病状态或病况，如癌症、骨质疏松症和青光眼等的各种方法。
• Substituted N'-(arylcarbonyl)-benzhydrazides, N'-(arylcarbonyl)-benzylidene-hydrazides and analogs as activators of caspases and inducers of apoptosis and the use thereof
  申请人：Cytovia, Inc.

  公开号：US20030013743A1

  公开（公告）日：2003-01-16

  The present invention is directed to substituted N′-(arylcarbonyl)-benzhydrazides, N′-(arylcarbonyl)-benzylidene-hydrazides and analogs thereof, represented by the Formulae I and II: 1 wherein Ar 1 , Ar 2 , and R 1 -R 2 are defined herein. The present invention also relates to the discovery that compounds having Formulae I and II are activators of caspases and inducers of apoptosis. Therefore, the activators of caspases and inducers of apoptosis of this invention may be used to induce cell death in a variety of clinical conditions in which uncontrolled growth and spread of abnormal cells occurs.

  本发明涉及取代N′-(芳基甲酰基)-苯基肼、N′-(芳基甲酰基)-苄基亚胺和类似物，其由下式I和II表示：其中Ar1、Ar2和R1-R2在此定义。本发明还涉及发现具有式I和II的化合物是caspase激活剂和凋亡诱导剂。因此，本发明的caspase激活剂和凋亡诱导剂可用于诱导各种临床病况中发生细胞死亡的情况，其中异常细胞的无序生长和扩散。
• [EN] COMPOSITIONS, MATERIALS, AND METHODS FOR DEACTIVATING TOXIC AGENTS<br/>[FR] COMPOSITIONS, MATÉRIAUX ET PROCÉDÉS DE DÉSACTIVATION D'AGENTS TOXIQUES
  申请人：INST FOR STEM CELL BIOLOGY AND REGENERATIVE MEDICINE INSTEM

  公开号：WO2019180653A1

  公开（公告）日：2019-09-26

  The present invention is related to a nucleophilic agent that includes a nucleophilic moiety and is capable of deactivating a toxic agent. The invention is also related to compositions or articles that include the nucleophilic agent. Methods of preparing and using the nucleophilic agents, the compositions and the articles are also included in the invention.

  本发明涉及一种包括亲核基团并能够使毒性剂失活的亲核试剂。该发明还涉及包括该亲核试剂的组合物或物品。发明还包括制备和使用亲核试剂、组合物和物品的方法。
• Hydrazones of Nitrophenyl and Pyridyl Aldehydes and Ketones. New Preparation of o-Nitrobenzophenones and Differences in Behavior of o-Nitrobenzophenone and o-Nitrophenyl Mesityl Ketone¹
  作者：H. Harry Szmant、Charles M. Harmuth

  DOI：10.1021/ja01513a051

  日期：1959.3
• ANTHELMINTIC PYRIDINYL ACYLHYDRAZONES, METHOD OF USE AND COMPOSITIONS
  申请人：THE UPJOHN COMPANY

  公开号：EP0214158A1

  公开（公告）日：1987-03-18