Benzene methylene chloride | 26473-50-7

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: Benzene methylene chloride
• 英文别名: benzene;dichloromethane
• CAS: 26473-50-7
• 化学式: C7H8Cl2
• 分子量: 163.04
• InChiKey: FXCLIEYDXXVEAI-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.11
• 重原子数：
  9
• 可旋转键数：
  0
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.14
• 拓扑面积：
  0
• 氢给体数：
  0
• 氢受体数：
  0

反应信息

• 作为试剂：
  描述：

  2-Cyano-3-phenyl-2-[4-(2,2,2-trifluoro-1-hydroxy-1-trifluoromethyl-ethyl)-phenylazo]-propionic acid ethyl ester 、 溶剂黄146 、 盐酸 、 碳酸氢钠 在 乙醚 、 Benzene methylene chloride 、 正己烷 作用下， 以 水 为溶剂， 反应 0.5h， 以to give α-[1-[4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl]hydrazin-2-ylidene]benzenepropanenitrile Isomer A as yellow crystals, m.p. 90°-92°的产率得到3-Phenyl-2-{[4-(2,2,2-trifluoro-1-hydroxy-1-trifluoromethyl-ethyl)-phenyl]-hydrazono}-propionitrile
  参考文献：
  名称：

  Indole compounds and process for their preparation

  摘要：

  本文披露了具有抑制血小板聚集作用并用于1,4-苯二氮平的中间体生产的吲哚化合物。

  公开号：

  US04156016A1

文献信息

• Compounds for the Treatment of Hepatitis C
  申请人：Martin Scott W.

  公开号：US20090280083A1

  公开（公告）日：2009-11-12

  The invention encompasses compounds of formula I as well as compositions and methods of using the compounds. The compounds have activity against hepatitis C virus (HCV) and are useful in treating those infected with HCV.

  这项发明涵盖了公式I的化合物，以及使用这些化合物的组合物和方法。这些化合物对丙型肝炎病毒（HCV）具有活性，并可用于治疗感染HCV的人。
• 4-Piperidinealkanamine derivatives
  申请人：FABRICA ESPANOLA DE PRODUCTOS QUIMICOS Y FARMACEUTICOS, S.A.

  公开号：EP0343307A1

  公开（公告）日：1989-11-29

  Compounds of general formula I (Z=O) are prepared by react­ing 4-piperidinealkanamines with carboxylic acids or reactive der­ivatives thereof, such as the esters of lower aliphatic alcohols or acid halides. Compounds of general formula I (Z=CONH) are likewise obtained by means of the reaction between 4-piperidinealcan­amines and isocyanates. The compounds of general formula I thus obtained, and the pharmaceutically acceptable salts thereof are of a great therapeutic utility, given their activity as specific antagonists of histamine H₁ receptors.

  通式I（Z=O）的化合物是通过将4-哌啶烷基胺与羧酸或其反应衍生物（如低碳醇酯或酸卤化物）反应制备而成的。通式I（Z=CONH）的化合物同样是通过4-哌啶烷胺和异氰酸酯之间的反应获得的。这样获得的通式I的化合物及其药用可接受的盐在治疗上具有极大的用途，因为它们作为组织胺H₁受体的特异拮抗剂而具有活性。
• [EN] TRIBOLUMINESCENT MATERIAL, USE OF A Cu COMPLEX AS A TRIBOLUMINESCENT MATERIAL, MECHANORESPONSIVE SENSOR AND METHOD FOR DETECTING A MECHANICAL LOADING<br/>[FR] MATÉRIAU TRIBOLUMINESCENT, UTILISATION D'UN COMPLEXE DE CU EN TANT QUE MATÉRIAU TRIBOLUMINESCENT, CAPTEUR MÉCANOSENSIBLE ET PROCÉDÉ POUR DÉTECTER UNE CHARGE MÉCANIQUE
  申请人：OKINAWA INST SCIENCE & TECH SCHOOL CORP

  公开号：WO2022014514A1

  公开（公告）日：2022-01-20

  Triboluminescent materials that generate emission of light in response to mechanical stimulus attract significant attention due to their applications in development of "smart materials" and damage sensors. Among metal complexes, rare-earth europium and terbium complexes are most widely used, while there is no systematic data on triboluminescence in more readily available and inexpensive Cu complexes, with only a few scattered examples reported in the literature. We report a new family of photoluminescent Cu-NHC complexes that show bright triboluminescence (TL) in crystal state visible even in ambient light under air upon grinding or crushing the crystalline sample. Moreover, when these complexes are dispersed into amorphous polymethylmethacrylate (PMMA) films even at small concentrations, TL is easily observed. In Cu-containing polymer films, surrounding gas discharge is likely involved in excitation of brightly luminescent Cu-NHC complexes. Observation of TL in polymer films overcomes limitations of using crystalline phase for mechanoresponse and opens up possibilities for development of mechanoresponsive coatings and materials based on inexpensive metals such as Cu.

  产生光发射以响应机械刺激的发光材料吸引了很大的关注，因为它们在“智能材料”和损伤传感器的开发中具有应用。在金属配合物中，稀土铕和铽配合物被广泛使用，而在更易获得和廉价的铜配合物中，尚无系统的触发发光数据，只有少数零星的例子报道在文献中。我们报告了一类新的具有明亮发光的铜-氮杂环卡宾配合物家族，在晶体状态下，即使在空气下，通过研磨或压碎晶体样品也可以看到明亮的发光。此外，当这些配合物分散到无定形聚甲基丙烯酸甲酯（PMMA）薄膜中，即使在低浓度下，也很容易观察到发光。在含铜聚合物薄膜中，周围气体放电可能参与激发明亮发光的铜-氮杂环卡宾配合物。在聚合物薄膜中观察到发光克服了使用晶体相进行机械响应的限制，并为基于廉价金属如铜的机械响应涂层和材料的开发打开了可能性。
• Heat-shock protein binders
  申请人：Bruncko Milan

  公开号：US20070105862A1

  公开（公告）日：2007-05-10

  Compounds which bind to and inhibit the activity of HSP90, compositions containing the compounds and methods of treating diseases that are caused or exascerbated by overexpression of HSP90 are disclosed.

  本发明公开了结合并抑制HSP90活性的化合物、含有该化合物的组合物以及治疗由HSP90过度表达引起或加重的疾病的方法。
• Protein arrays
  申请人：The Scripps Research Institute

  公开号：US20040198637A1

  公开（公告）日：2004-10-07

  The invention provides proteins attached to solid supports, and methods of preparing such solid support-bound proteins are provided. The proteins are attached to solid supports by means of an unnatural amino acid incorporated into the protein, which unnatural amino acid includes a reactive group that can react with a second reactive group that is attached to a solid support.

  本发明提供了附着在固体支持物上的蛋白质，以及制备这种固体支持物-蛋白质的方法。这些蛋白质通过将非天然氨基酸并入蛋白质中，将其与固体支持物结合，这种非天然氨基酸包含一个反应基团，可以与连接到固体支持物上的第二个反应基团反应。