3-羟基-4-羟基甲基-吡咯烷-1-羧酸叔丁酯 | 147722-75-6

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡咯烷类
• 中文名称: 3-羟基-4-羟基甲基-吡咯烷-1-羧酸叔丁酯
• 英文名称: tert-butyl 3-hydroxy-4-(hydroxymethyl)pyrrolidine-1-carboxylate
• 英文别名: (3R,4R)-(1-tert-Butoxycarbonyl-4-hydroxypyrrolidin-3-yl)methanol；3-hydroxy-4-hydroxymethyl-pyrrolidine-1-carboxylic acid tert-butyl ester
• CAS: 147722-75-6
• 化学式: C₁₀H₁₉NO₄
• 分子量: 217.265
• InChiKey: BSTWKRUNXOFBPE-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.4
• 重原子数：
  15
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.9
• 拓扑面积：
  70
• 氢给体数：
  2
• 氢受体数：
  4

安全信息

• 危险性防范说明：
  P261,P264,P271,P280,P302+P352,P304+P340,P305+P351+P338,P312,P362,P403+P233,P501
• 危险性描述：
  H315,H319,H335

反应信息

• 作为反应物：
  描述：

  3-羟基-4-羟基甲基-吡咯烷-1-羧酸叔丁酯 在 吡啶 、 甲基磺酰氯 、 sodium azide 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 反应 2.5h， 以85%的产率得到(3RS)-(4RS)-3-azidomethyl-4-hydroxy-pyrrolidine-1-carboxylic acid tert-butyl ester
  参考文献：
  名称：

  WO2008/126034

  摘要：

  公开号：
• 作为产物：
  描述：

  N-BOC-4-氧代-3-吡咯烷甲酸乙酯 在 sodium tetrahydroborate 作用下， 以 乙醇 为溶剂， 反应 15.0h， 生成 3-羟基-4-羟基甲基-吡咯烷-1-羧酸叔丁酯
  参考文献：
  名称：

  [EN] APOL1 INHIBITORS AND METHODS OF USE
  [FR] INHIBITEURS D'APOL1 ET MÉTHODES D'UTILISATION

  摘要：

  Provided herein are compounds of formula (A'): or a stereoisomer or tautomer thereof, or a pharmaceutically acceptable salt of any of the foregoing, wherein X1, X2, X3, X4, Ra, Rb, Rc, L, Q, and Y are as defined herein. Also provided are methods of inhibiting APOL1 and methods of preparing compounds of formula (A'). Also provided are methods of inhibiting APOL1 and methods of treating an APOL1 -mediated disease, disorder, or condition in an individual.

  公开号：

  WO2022178315A1

文献信息

• OXAZOLIDINONE ANTIBIOTICS
  申请人：Bur Daniel

  公开号：US20110039823A1

  公开（公告）日：2011-02-17

  The invention relates to compounds of formula (I) wherein U, V, W, X, R1, R2, R3, R4, R5, R6, A, B, D, E, G, m, and n are as defined in the description, to pharmaceutically acceptable salts of such compounds for use in the manufacture of a medicament for the prevention or treatment of a bacterial infection. Certain compounds of formula (I) are new and are also part of this invention.

  本发明涉及式(I)的化合物，其中U、V、W、X、R1、R2、R3、R4、R5、R6、A、B、D、E、G、m和n的定义如说明书中所述，还涉及用于制造预防或治疗细菌感染的药物的上述化合物的药用可接受盐。式(I)中的某些化合物是新颖的，也是本发明的一部分。
• [EN] METHODS FOR PREPARING FLUOROALKYL ARYLSULFINYL COMPOUNDS AND FLUORINATED COMPOUNDS THERETO<br/>[FR] PROCÉDÉS DE PRÉPARATION DE COMPOSÉS FLUOROALKYLE ARYLSULFINYLÉS ET COMPOSÉS FLUORÉS APPARENTÉS
  申请人：IM & T RES INC

  公开号：WO2010022001A1

  公开（公告）日：2010-02-25

  Novel preparative methods for fluoroalkyl arylsulfinyl compounds are disclosed. Fluorinated compounds as useful fluorinated compounds, intermediates, or builing blocks are disclosed. Useful applications of the fluoroalkyl arylsulfinyl compounds are shown.

  揭示了用于制备氟烷基芳基磺酰基化合物的新型制备方法。公开了氟化合物作为有用的氟化合物、中间体或构建块。展示了氟烷基芳基磺酰基化合物的有用应用。
• [EN] SALT AND POLYMORPHIC FORMS OF (3R,4S)-L-((4-AMINO-5H-PYRROLO[3,2-D]PYRIMIDIN-7-YL)METHYL)-4(METHYLTHIOMETHYL)PYRODIN-3-OL(MTDIA)<br/>[FR] FORMES DE SEL ET FORMES POLYMORPHES DE (3R,4S)-1-((4-AMINO-5H-PYRROLO[3,2-D]PYRIMIDIN-7-YL)METHYL)-4-(METHYLTHIOMETHYL)PYRROLIDIN-3-OL (MTDIA)
  申请人：CALLAGHAN INNOVATION RES LTD

  公开号：WO2014073989A1

  公开（公告）日：2014-05-15

  The invention relates to salt forms of (3R,4S)-1-((4-amino-5H-pyrrolo[3,2-d]pyrimidin-7-yl)methyl)-4-(methylthiomethyl)pyrrolidin-3-ol, as well as polymorphic forms of the salts. The invention further relates to processes for preparing the salt forms and to the use of the salt forms in the treatment of diseases and disorders where it is desirable to inhibit 5'-methylthioadenosine phosphorylase (MTAP).

  该发明涉及(3R,4S)-1-((4-氨基-5H-吡咯并[3,2-d]嘧啶-7-基)甲基)-4-(甲硫甲基)吡咯烷-3-醇的盐形式，以及盐的多形式。该发明还涉及制备盐形式的过程，以及在治疗需要抑制5'-甲硫腺苷磷酸化酶（MTAP）的疾病和疾病时使用盐形式。
• PYRROLOPYRIMIDINE AND PURINE DERIVATIVES
  申请人：Cheng Hengmiao

  公开号：US20130079324A1

  公开（公告）日：2013-03-28

  The present invention relates to compounds of formula (I) or pharmaceutically acceptable salts thereof, wherein Q, T, V, W, X, Y, Z, ring A, R 1 , R 2 , R 3 , R 4 , R 5 , R 5a , R 6 , R 7 , R 8 , R 9 , R 10 , R 11 , R 12 , R 13 , R 14 , R 15 , R 16 , R 17 and m are defined herein. There novel pyrrolopyrimidine and purine derivatives are useful in the treatment of abnormal cell growth, such as cancer, in mammals. Additional embodiments relate to pharmaceutical compositions containing the compounds and to methods of using the compounds and compositions in the treatment of abnormal cell growth in mammals.

  本发明涉及式（I）的化合物或其药学上可接受的盐，其中Q、T、V、W、X、Y、Z、环A、R1、R2、R3、R4、R5、R5a、R6、R7、R8、R9、R10、R11、R12、R13、R14、R15、R16、R17和m在此定义。这些新颖的吡咯嘧啶和嘌呤衍生物在哺乳动物中治疗异常细胞生长，如癌症方面具有用处。另外，本发明还涉及含有这些化合物的药物组合物，以及在哺乳动物中治疗异常细胞生长的方法。
• 5h-pyrrolo[3,2-D] pyrimidine inhibitors of nucleoside phosphorylases and nucleosidases
  申请人：Industrial Research Limited

  公开号：US07553839B2

  公开（公告）日：2009-06-30

  The present invention relates to compounds of the general formula (I) which are inhibitors of purine muclioside phosphorylases (PNP), purine phosphoribosyltransferases (PPRT), 5′-methylthioadenosine phosphorylases (MTAP), 5′-methylthioadenosine mucliosidases (MTAN) and/or nucleoside hydrolases (NH). The invention also relates to the use of these compounds in the treatment of diseases and infections including cancer, bacterial infections, protozoal infections, and T-cell mediated disease and to pharmaceutical compositions containing the compounds.

  本发明涉及一般式（I）的化合物，其为嘌呤核苷酸磷酸酯酶（PNP）、嘌呤磷酸核糖转移酶（PPRT）、5'-甲基硫腺苷磷酸酶（MTAP）、5'-甲基硫腺苷核苷酸酶（MTAN）和/或核苷酸水解酶（NH）的抑制剂。本发明还涉及这些化合物在治疗包括癌症、细菌感染、原虫感染和T细胞介导疾病等疾病和感染中的应用，以及包含这些化合物的制药组合物。