5-bromo-2-methoxy-1,3-bis[(4R)-4-methoxy-4-phenyl-2-oxobutyl]benzene | 548485-30-9

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 5-bromo-2-methoxy-1,3-bis[(4R)-4-methoxy-4-phenyl-2-oxobutyl]benzene
• 英文别名: 5-bromo-2-methoxy-1,3-bis[[(2R)-2-methoxy-2-phenylethoxy]methyl]benzene
• CAS: 548485-30-9
• 化学式: C₂₇H₃₁BrO₅
• 分子量: 515.444
• InChiKey: SKINREXCUSCGOV-UIOOFZCWSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.6
• 重原子数：
  33
• 可旋转键数：
  13
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  46.2
• 氢给体数：
  0
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  5-bromo-2-methoxy-1,3-bis[(4R)-4-methoxy-4-phenyl-2-oxobutyl]benzene 在 正丁基锂 、 水 作用下， 以 四氢呋喃 、 正己烷 为溶剂， 以75%的产率得到2-methoxy-1,3-bis[(4R)-4-methoxy-4-phenyl-2-oxobutyl]benzene
  参考文献：
  名称：

  Preparation of phenolic chiral crown ethers and podands and their enantiomer recognition ability toward secondary amines

  摘要：

  Phenolic pseudo-24-crown-8 (S,S)-3, pseudo-27-crown-9 (S,S)-4, and podands (R,R)-5 and (R,R)-6 possessing phenyl groups as chiral barriers were prepared and their chiral recognition properties toward secondary neutral amines were examined. Pseudo-24-crown-8 (S,S)-3 and podand (R,R)-5 showed sufficient binding ability and moderate chiral recognition ability toward secondary amines. (C) 2003 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0957-4166(03)00031-4
• 作为产物：
  描述：

  5-bromo-1,3-bis[(4R)-4-hydroxy-4-phenyl-2-oxobutyl]-2-methoxybenzene 、 碘甲烷 在 sodium hydride 作用下， 以 四氢呋喃 为溶剂， 反应 3.0h， 以86%的产率得到5-bromo-2-methoxy-1,3-bis[(4R)-4-methoxy-4-phenyl-2-oxobutyl]benzene
  参考文献：
  名称：

  Preparation of phenolic chiral crown ethers and podands and their enantiomer recognition ability toward secondary amines

  摘要：

  Phenolic pseudo-24-crown-8 (S,S)-3, pseudo-27-crown-9 (S,S)-4, and podands (R,R)-5 and (R,R)-6 possessing phenyl groups as chiral barriers were prepared and their chiral recognition properties toward secondary neutral amines were examined. Pseudo-24-crown-8 (S,S)-3 and podand (R,R)-5 showed sufficient binding ability and moderate chiral recognition ability toward secondary amines. (C) 2003 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0957-4166(03)00031-4

文献信息

• Preparation of phenolic chiral crown ethers and podands and their enantiomer recognition ability toward secondary amines
  作者：Keiji Hirose、Akihito Fujiwara、Kazuhisa Matsunaga、Nobuaki Aoki、Yoshito Tobe

  DOI：10.1016/s0957-4166(03)00031-4

  日期：2003.3

  Phenolic pseudo-24-crown-8 (S,S)-3, pseudo-27-crown-9 (S,S)-4, and podands (R,R)-5 and (R,R)-6 possessing phenyl groups as chiral barriers were prepared and their chiral recognition properties toward secondary neutral amines were examined. Pseudo-24-crown-8 (S,S)-3 and podand (R,R)-5 showed sufficient binding ability and moderate chiral recognition ability toward secondary amines. (C) 2003 Elsevier Science Ltd. All rights reserved.