2,6-dimethoxy-4-hydroxybenzoic acid | 84741-02-6

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2,6-dimethoxy-4-hydroxybenzoic acid
• 英文别名: 4-Hydroxy-2,6-dimethoxybenzoic acid
• CAS: 84741-02-6
• 化学式: C₉H₁₀O₅
• mdl: MFCD00192061
• 分子量: 198.175
• InChiKey: HIVSALLSJIAQQF-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.1
• 重原子数：
  14
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.222
• 拓扑面积：
  76
• 氢给体数：
  2
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  2,6-dimethoxy-4-hydroxybenzoic acid 在 四氯化碳 、 氯 作用下， 生成 3,5-dichloro-4-hydroxy-2,6-dimethoxy-benzoic acid
  参考文献：
  名称：

  Grove et al., Journal of the Chemical Society, 1952, p. 3949,3957

  摘要：

  DOI：
• 作为产物：
  描述：

  2,2,2-trichloro-1-(4-hydroxy-2,6-dimethoxy-phenyl)-ethanone 在 sodium hydroxide 作用下， 生成 2,6-dimethoxy-4-hydroxybenzoic acid
  参考文献：
  名称：

  713.有机氟化合物。第六部分 一些三氟甲基色酮和-香豆素

  摘要：

  DOI：

  10.1039/jr9510003235

文献信息

• Cardiac risk assessment for noncardiac surgery: Current concepts
  作者：Aman Chugh、Eduardo Bossone、Rajendra H. Mehta

  DOI：10.1007/s12019-001-0007-3

  日期：2001.3

  Strategies for perioperative risk assessment in patients undergoing noncardiac surgery vary among physicians and are aimed to estimate the risk and minimize complications. We propose simplistic guidelines for assessing and modifying risk for patients undergoing a wide variety of procedures.

  不同医生对接受非心脏手术的患者进行围手术期风险评估的策略各不相同，其目的都是为了估计风险并将并发症降至最低。我们为接受各种手术的患者提出了评估和调整风险的简易指南。
• MACROCYCLES AND MACROCYCLE STABILIZED PEPTIDES
  申请人：Saulnier Mark G.

  公开号：US20130281657A1

  公开（公告）日：2013-10-24

  The invention provides methods of preparing macrocycles including macrocycle stabilized peptides (MSPs). Macrocycles and MSPs are prepared according to nucleophilic capture of an iminoquinomethide type intermediate generated from a suitably substituted 2-amino-thiazol-5-yl carbinol. The preferred nucleophile may be selected from an electron rich aromatic moiety in the case of macrocycles and, in the case of MSPs, at least one amino acid comprises an electron rich aromatic moiety. In addition, the concept can be extended to other related 5-membered heterocyclic systems in place of the thiazole, such as imidazole or oxazole. The conditions for the generation of the corresponding iminoquinomethide type intermediates may be similar or different than the conditions used for the 2-amino-thiazol-5-yl carbinol.

  本发明提供了制备大环化合物的方法，包括稳定大环化肽（MSPs）。根据适当取代的2-氨基噻唑-5-基甲醇生成的亚胺喹啉甲烷型中间体的亲核捕获，制备大环和MSP。在大环的情况下，首选亲核试剂可以从富电子芳香基团中选择，在MSP的情况下，至少有一种氨基酸包含富电子芳香基团。此外，该概念可以扩展到取代噻唑的其他相关5-成员杂环系统，例如咪唑或噁唑。生成相应的亚胺喹啉甲烷型中间体的条件可能与用于2-氨基噻唑-5-基甲醇的条件相似或不同。
• METHOD FOR PRODUCING ORGANIC COMPOUND
  申请人：Unitika Ltd.

  公开号：EP3819283A1

  公开（公告）日：2021-05-12

  The present invention provides a production method of an organic compound, in which a reaction is performed between functional groups without using any solvents. The present invention relates to a production method of an organic compound, in which a reaction is performed between functional groups by using a mechanochemical effect.

  本发明提供了一种有机化合物的生产方法，其中官能团之间的反应是在不使用任何溶剂的情况下进行的。本发明涉及一种有机化合物的生产方法，其中官能团之间的反应是通过机械化学效应进行的。
• METHODS FOR PREPARING MACROCYCLES AND MACROCYCLE STABILIZED PEPTIDES
  申请人：Bristol-Myers Squibb Company

  公开号：EP2627662B1

  公开（公告）日：2015-09-16
• PRODUCTION METHOD OF ORGANIC COMPOUND
  申请人：UNITIKA LTD.

  公开号：US20210139390A1

  公开（公告）日：2021-05-13

  The present invention provides a production method of an organic compound, in which a reaction is performed between functional groups without using any solvents. The present invention relates to a production method of an organic compound, in which a reaction is performed between functional groups by using a mechanochemical effect.