4-[2-(Dimethylamino)ethoxy]benzenesulfonamide | 616880-13-8

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 4-[2-(Dimethylamino)ethoxy]benzenesulfonamide
• CAS: 616880-13-8
• 化学式: C₁₀H₁₆N₂O₃S
• mdl: MFCD23714708
• 分子量: 244.31
• InChiKey: IRIGVOZTLXJUNH-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.9
• 重原子数：
  16
• 可旋转键数：
  5
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.4
• 拓扑面积：
  81
• 氢给体数：
  1
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  Phenyl 2-[4-(3,5-dimethyl-4-phenyl-1H-pyrazol-1-yl)phenyl]ethylcarbamate 、 4-[2-(Dimethylamino)ethoxy]benzenesulfonamide 生成 4-[2-(dimethylamino)ethoxy]-N-[({2-[4-(3,5-dimethyl-4-phenyl-1H-pyrazol-1-yl)phenyl]ethyl}amino) carbonyl]benzenesulfonamide
  参考文献：
  名称：

  Pyrazole compounds as anti-inflammatory and analgesic agents

  摘要：

  本发明提供了化合物(I)的公式，其中：R1代表氢原子，烷基等；R2代表氢原子，卤原子等；R3代表烷基等；R4代表芳基等；A代表芳基1等；B代表烷基等；X代表NH等；或该化合物的医药上可接受的酯及其医药上可接受的盐。这些化合物对于治疗由前列腺素介导的医学状况，如疼痛，发热或炎症等，是有用的。本发明还提供了包含上述化合物的制药组合物。

  公开号：

  US07001917B2

文献信息

• Non explosive bis-sulfonyl azides
  申请人：DYNAMIT NOBEL GMBH EXPLOSIVSTOFF-UND SYSTEMTECHNIK

  公开号：US10385016B2

  公开（公告）日：2019-08-20

  The invention relates to a compound of the general formula (I) N3O2S—Ar-L-Ar′—SO2N3, wherein: —Ar and Ar′ are aromatic building blocks; and —L is a linking group comprising at least one heteroatom as well as an organic chain denoted as Sp″ and having at least two carbon atoms. The invention also relates to a compound of the general formula (II) wherein: —Ar and Ar′ are aromatic building blocks; —L is a covalent bond or a linking group; —m and n are both 0 or 1, at least one of m and n being 1; —Sp and Sp′ are organic chains having at least two carbon atoms. The invention also relates to the use of these compounds as cross linking agents in the manufacture of polymers.

  本发明涉及通式(I)为N3O2S-Ar-L-Ar′-SO2N3的化合物，其中：-Ar和Ar′是芳香族结构单元；-L是连接基团，包括至少一个杂原子以及表示为Sp″的至少有两个碳原子的有机链。本发明还涉及通式(II)的化合物，其中：-Ar和Ar′是芳香族结构单元；-L是共价键或连接基团；-m和n都是0或1，m和n中至少有一个是1；-Sp和Sp′是至少具有两个碳原子的有机链。本发明还涉及将这些化合物用作制造聚合物的交联剂。
• PYRAZOLE COMPOUNDS AS ANTI-INFLAMMATORY AND ANALGESIC AGENTS
  申请人：Pfizer Japan Inc.

  公开号：EP1495005A1

  公开（公告）日：2005-01-12
• NON EXPLOSIVE BIS-SULFONYL AZIDES
  申请人：DYNAMIT NOBEL GMBH EXPLOSIVSTOFF- UND SYSTEMTECHNIK

  公开号：US20180050988A1

  公开（公告）日：2018-02-22

  The invention relates to a compound of the general formula (I) N 3 O 2 S—Ar-L-Ar′—SO 2 N 3 , wherein: —Ar and Ar′ are aromatic building blocks; and —L is a linking group comprising at least one heteroatom as well as an organic chain denoted as Sp″ and having at least two carbon atoms. The invention also relates to a compound of the general formula (II) wherein: —Ar and Ar′ are aromatic building blocks; —L is a covalent bond or a linking group; —m and n are both 0 or 1, at least one of m and n being 1; —Sp and Sp′ are organic chains having at least two carbon atoms. The invention also relates to the use of these compounds as cross linking agents in the manufacture of polymers
• US7001917B2
  申请人：——

  公开号：US7001917B2

  公开（公告）日：2006-02-21
• [EN] PYRAZOLE COMPOUNDS AS ANTI-INFLAMMATORY AND ANALGESIC AGENTS<br/>[FR] COMPOSES DE PYRAZOLE EN TANT QU'AGENTS ANTI-INFLAMMATOIRES ET ANALGESIQUES
  申请人：PFIZER PHARMA

  公开号：WO2003087061A1

  公开（公告）日：2003-10-23

  This invention provides a compound of the formula (I): wherein: R1 represents a hydrogen atom, an alkyl group, etc.; R2 represents a hydrogen atom, a halogen atom, etc.; R3 represents an alkyl group, etc.; R4 represents an aryl group, etc.; A represents an aryll, etc; B represents an alkylene etc.; X represents NH, etc.; or a pharmaceutically acceptable ester of such compound, and pharmaceutically acceptable salts thereof. These compounds are useful for the treatment of medical conditions mediated by prostaglandin such as pain, fever or inflammation, etc. This invention also provides a pharmaceutical composition comprising the above compound.