2-Amino-4-phenoxy-butan-1-ol | 66233-17-8

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯酚醚
• 英文名称: 2-Amino-4-phenoxy-butan-1-ol
• 英文别名: 2-Amino-4-phenoxy-1-butanol；2-amino-4-phenoxybutan-1-ol
• CAS: 66233-17-8
• 化学式: C₁₀H₁₅NO₂
• 分子量: 181.235
• InChiKey: IFARCTHCJDXCSH-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.7
• 重原子数：
  13
• 可旋转键数：
  5
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.4
• 拓扑面积：
  55.5
• 氢给体数：
  2
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  2-Amino-4-(naphthalen-1-yloxy)-butyric acid 、 2-amino-4-phenoxybutanoic acid 以, 24, 1794 (1959), 2-amino-4-phenoxy-1-butanol, γmaxCHCl3 3230-3400, is obtained的产率得到2-Amino-4-phenoxy-butan-1-ol
  参考文献：
  名称：

  Aryloxy aminobutanols, their preparation and use thereof

  摘要：

  本文披露了式子##STR1##的化合物，其中Ar是苯或1-萘基；R.sup.1是氢或低碳基；而R.sup.2和R.sup.3是相同或不同的从氢或低碳基选择的群组，但是当R.sup.1为低碳基时，R.sup.2是相同的低碳基。这些化合物是抗抑郁剂，还披露了它们的制备和使用方法。

  公开号：

  US04071552A1

文献信息

• 4,5-DIHYDRO-OXAZOL-2YL DERIVATIVES
  申请人：Galley Guido

  公开号：US20100029589A1

  公开（公告）日：2010-02-04

  The invention relates to compounds of formula I wherein R 1 , R 2 , X, Y, and n are defined in the specification and to pharmaceutically acceptable acid addition salts thereof. The invention also provides pharmaceutical compositions and methods of manufacture of such compounds. The compounds are useful for the treatment of diseases related to the biological function of the trace amine associated receptors, which diseases are depression, anxiety disorders, bipolar disorder, attention deficit hyperactivity disorder, stress-related disorders, psychotic disorders, schizophrenia, neurological diseases, Parkinson's disease, neurodegenerative disorders, Alzheimer's disease, epilepsy, migraine, substance abuse and metabolic disorders, eating disorders, diabetes, diabetic complications, obesity, dyslipidemia, disorders of energy consumption and assimilation, disorders and malfunction of body temperature homeostasis, disorders of sleep and circadian rhythm, and cardiovascular disorders.

  该发明涉及公式I的化合物，其中R1、R2、X、Y和n在规范中定义，并且其药学上可接受的酸盐。该发明还提供了制备这种化合物的药物组合物和方法。这些化合物可用于治疗与痕量胺相关受体的生物功能相关的疾病，这些疾病包括抑郁症、焦虑症、躁郁症、注意缺陷多动障碍、与压力有关的疾病、精神疾病、精神分裂症、神经系统疾病、帕金森病、神经退行性疾病、阿尔茨海默病、癫痫、偏头痛、物质滥用和代谢紊乱、进食障碍、糖尿病、糖尿病并发症、肥胖症、脂质代谢异常、能量消耗和吸收异常、体温稳态异常、睡眠和昼夜节律异常、心血管疾病。
• Aryloxy aminobutanols for alleviating symptoms of depression
  申请人：Ayerst, McKenna & Harrison Limited

  公开号：US04118511A1

  公开（公告）日：1978-10-03

  Disclosed herein are compounds of the formula ##STR1## in which Ar is phenyl or 1-naphthyl; R.sup.1 is hydrogen or lower alkyl; and R.sup.2 and R.sup.3 are either the same or different selected from the group consisting of hydrogen or lower alkyl; with the proviso that when R.sup.1 is lower alkyl then R.sup.2 is the same lower alkyl. The compounds are antidepressant agents and methods for their preparation and use also are disclosed.

  本文披露了公式##STR1##的化合物，其中Ar为苯或1-萘基；R.sup.1为氢或低碳基；R.sup.2和R.sup.3为氢或低碳基，且有一个限制条件，即当R.sup.1为低碳基时，R.sup.2为相同的低碳基。这些化合物是抗抑郁剂，并且还披露了它们的制备和使用方法。
• TRICYCLIC ERYTHROMYCIN DERIVATIVES
  申请人：Abbott Laboratories

  公开号：EP0876388A1

  公开（公告）日：1998-11-11
• 4,5-DIHYDRO-OXAZOL-2-YL DERIVATIVES
  申请人：F. Hoffmann-La Roche AG

  公开号：EP2321287A1

  公开（公告）日：2011-05-18
• US4071552A
  申请人：——

  公开号：US4071552A

  公开（公告）日：1978-01-31