2-Methyl-4-chlorstyrol | 121135-78-2

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2-Methyl-4-chlorstyrol
• 英文别名: 2-Methyl-4-chlorostyrene；4-chloro-1-ethenyl-2-methylbenzene
• CAS: 121135-78-2
• 化学式: C₉H₉Cl
• 分子量: 152.623
• InChiKey: BPVVTRJJQZINNG-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.2
• 重原子数：
  10
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.11
• 拓扑面积：
  0
• 氢给体数：
  0
• 氢受体数：
  0

反应信息

• 作为反应物：
  描述：

  2-Methyl-4-chlorstyrol 在 dimethyl sulfide borane 、 三乙胺 作用下， 以 四氢呋喃 、 二氯甲烷 为溶剂， 反应 6.5h， 生成
  参考文献：
  名称：

  [EN] HISTONE DEMETHYLASE INHIBITORS
  [FR] INHIBITEURS D'HISTONES DÉMÉTHYLASES

  摘要：

  这份披露涉及抑制组蛋白去甲基化酶活性的化合物。具体而言，该披露涉及抑制组蛋白赖氨酸去甲基化酶KDM5B的化合物，以及使用这些化合物和药物组合物的方法，例如使用本文披露的化合物和药物组合物治疗癌症的方法。

  公开号：

  WO2017143011A1

文献信息

• New carboxamide compounds having melanin concentrating hormone antagonistic activity, pharmaceutical preparations comprising these compounds and process for their manufacture
  申请人：Boehringer Ingelheim International GmbH

  公开号：US20040242572A1

  公开（公告）日：2004-12-02

  The present invention relates to carboxamide compounds of general formula I 1 wherein the groups and residues A, B, W, X, Y, Z, R 1 , R 2 , R 3 and k have the meanings given in claim 1. Moreover the invention relates to process for preparing the above mentioned carboxamides as well as pharmaceutical compositions containing at least one carboxamide according to the invention. In view of their MCH-receptor antagonistic activity the pharmaceutical compositions according to the invention are suitable for the treatment of metabolic disorders and/or eating disorders, particularly obesity, bulimia, anorexia, hyperphagia and diabetes.

  本发明涉及具有通式I的羧酰胺化合物 1 其中，A、B、W、X、Y、Z、R 1 、R 2 、R 3 和k的含义如权利要求1中所述。此外，本发明还涉及制备上述羧酰胺的方法以及含有至少一种根据本发明的羧酰胺的药物组合物。由于它们对MCH受体的拮抗活性，根据本发明的药物组合物适合用于治疗代谢紊乱和/或饮食紊乱，特别是肥胖症、厌食症、暴食症、糖尿病。
• Transparent polycarbonate polyester composition and process
  申请人：——

  公开号：US20040097662A1

  公开（公告）日：2004-05-20

  Disclosed is a transparent/translucent molding composition and process for making prepared from an impact modifier and a resin blend of polycarbonate and a cycloaliphatic polyester having a matching index of refraction.

  公开了一种透明/半透明的模塑组合物和制备过程，该组合物由冲击改性剂和聚碳酸酯和环状脂肪族聚酯的树脂混合物制成，具有匹配的折射率指数。
• 3-Imidazolyl-Indoles for the Treatment of Proliferative Diseases
  申请人：Boettcher Andreas

  公开号：US20100125064A1

  公开（公告）日：2010-05-20

  The invention relates to 3-heterocyclyl indolyl compounds capable of inhibiting the interaction between p53, or variants thereof, and MDM2 and/or MDM4, or variants thereof, respectively, said compounds having the formula I, wherein R 1 , R 2 , R 3 , R 4 , R A , Y and Y are as defined in the specification. Due to their activity, the compounds are useful in the treatment of various disorders and diseases mediated by the activity of MDM2 and/or MDM4, or variants thereof, such as inflammatory or proliferative diseases or in the protection of cells.

  本发明涉及能够抑制p53或其变体与MDM2和/或MDM4或其变体相互作用的3-杂环基吲哚化合物，其中所述化合物具有式I，其中R1、R2、R3、R4、RA、Y和Y的定义见说明书。由于其活性，这些化合物可用于治疗由MDM2和/或MDM4或其变体介导的各种疾病和疾病，例如炎症性或增殖性疾病或细胞保护。
• Transparent Polycarbonate Polyester Composition and Process
  申请人：Gaggar Satish Kumar

  公开号：US20110086951A1

  公开（公告）日：2011-04-14

  Disclosed is a transparent/translucent molding composition and process for making prepared from an impact modifier and a resin blend of polycarbonate and a cycloaliphatic polyester having a matching index of refraction.

  本发明涉及一种透明/半透明的模塑组合物和制备方法，该组合物由冲击改性剂和聚碳酸酯和环状脂肪族聚酯的树脂混合物制成，其具有匹配的折射率指数。
• MODIFIED CARBON BLACK AND PREPARATION METHOD THEREFOR
  申请人：ZHANG Yigang

  公开号：US20160251519A1

  公开（公告）日：2016-09-01

  The present invention provides a modified carbon black, with an unsaturated coupling agent being grafted on the surface thereof. An unsaturated double bond on one end of the coupling agent is grafted on the surface of the carbon black to serves as a grafting group; and an active group on the other end serves as a crosslink group to retain a crosslinking function with rubber in the future. At least one coupling agent is selected from sulfur-containing compound, halogen-containing compound, nitrogen-containing compound, polyunsaturated compound. The present invention also provides an energy ball milling preparation method for the described product, and provides the formulas and preparation method of two kinds of sulfur-containing unsaturated coupling agent i.e., thioether and thiuram compounds for the described product. The modified carbon black could be crosslinked together with tire rubber. If the carbon black does not move, the rubber also does not move, thereby improving wet grip and driving safety. If the rubber moves, the carbon black also move, thereby reducing internal friction and saving oil, and reducing heat generated from the tire and prolonging the service life of the tire.

  本发明提供了一种改性碳黑，其表面接枝有不饱和偶联剂。偶联剂一端的不饱和双键被接枝在碳黑表面上，作为接枝基团；另一端的活性基团作为交联基团，将来与橡胶保持交联功能。至少选择一种偶联剂，包括含硫化合物、含卤化合物、含氮化合物、多不饱和化合物。本发明还提供了所述产品的能量球磨制备方法，并提供了两种含硫不饱和偶联剂即硫醚和硫脲化合物的配方和制备方法。改性碳黑可以与轮胎橡胶交联。如果碳黑不动，橡胶也不动，从而提高湿地抓地力和行车安全性。如果橡胶移动，碳黑也移动，从而减少内部摩擦和节省油耗，减少轮胎产生的热量并延长轮胎使用寿命。