1,2-bis(diphenylphosphino)hexane | 163189-33-1

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 1,2-bis(diphenylphosphino)hexane
• 英文别名: 1-Diphenylphosphanylhexan-2-yl(diphenyl)phosphane
• CAS: 163189-33-1
• 化学式: C₃₀H₃₂P₂
• 分子量: 454.532
• InChiKey: ZWAJONDTYCQXGB-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  7.7
• 重原子数：
  32
• 可旋转键数：
  10
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.2
• 拓扑面积：
  0
• 氢给体数：
  0
• 氢受体数：
  0

反应信息

• 作为反应物：
  描述：

  1,2-bis(diphenylphosphino)hexane 在 双氧水 作用下， 生成 hexane-1,2-diylbis(diphenylphosphine oxide)
  参考文献：
  名称：

  Khachatryan, R. A.; Grigoryan, N. Yu.; Indzhikyan, M. G., Russian Journal of General Chemistry, 1994, vol. 64, # 8.1, p. 1134 - 1138

  摘要：

  DOI：
• 作为产物：
  描述：

  1-己炔 、 二苯基膦 在 1,3-二叔丁基咪唑-2-叉 、 copper dichloride 作用下， 以 neat (no solvent) 为溶剂， 反应 24.0h， 以79%的产率得到1,2-bis(diphenylphosphino)hexane
  参考文献：
  名称：

  在炔烃上依次向膦中添加膦，以在催化下选择性合成1,2-二膦基乙烷。定义明确的NHC铜磷酸盐与原位CuCl2 / NHC催化剂

  摘要：

  The well-defined NHC-copper phosphides [(NHC)CuPPh2](3) (1, NHC = 1,3-diisopropy1-4,5-dimethyli- midazol-2-ylidene (I'Pr); 2, NHC = N,N-di-tert-butylimidazol-2-ylidene ((IBu)-Bu-t)) have been prepared by the reaction of simple copper halides with HPPh2 in the presence of N-heterocyclic carbenes (NHCs). Complexes 1 and 2 enabled catalytic double hydrophosphination of alkyl and aryl terminal alkynes to yield 1,2-diphosphinoethanes selectively in good yields. On the basis of these results, the most efficient and pratical in situ CuCl2/NHC catalyst has been developed. It catalyzes the selective double hydrophosphination of the alkynes with high efficiency and a wide substrate scope and exhibits even better performance than the well-defined NHC-Cu phosphides. The mechanistic studies disclosed that the formation of a copper acetylide in the catalytic cycle played an important role in the acceleration of the catalytic process.

  DOI：

  10.1021/acs.organomet.6b00854

文献信息

• ANTI-CANCER PHOSPHINE CONTAINING [AuIIIm(CNC)mL]n+ COMPLEXES AND DERIVATIVES THEREOF AND METHODS FOR TREATING CANCER USING SUCH COMPOSITIONS
  申请人：Che Chi Ming

  公开号：US20080166429A1

  公开（公告）日：2008-07-10

  Gold(III)phosphine complexes [Au m (CNC) m L] n+ (where HCNCH=2,6-diphenylpyridine) and their use as anti-tumor agents are disclosed. Notable results for the appearance of new potential anti-tumor application of these gold(III) complexes are reported. The described complexes show promising cytotoxic properties toward cancer cells in both in vitro and in vivo studies.
• US7632827B2
  申请人：——

  公开号：US7632827B2

  公开（公告）日：2009-12-15