(2R)-2-(氨基甲基)-4,4-二氟吡咯烷-1-羧酸叔丁酯 | 1407991-24-5

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡咯烷类
• 中文名称: (2R)-2-(氨基甲基)-4,4-二氟吡咯烷-1-羧酸叔丁酯
• 英文名称: tert-butyl (2R)-2-(aminomethyl)-4,4-difluoropyrrolidine-1-carboxylate
• 英文别名: (R)-1-Boc-2-(aminomethyl)-4,4-difluoropyrrolidine
• CAS: 1407991-24-5
• 化学式: C₁₀H₁₈F₂N₂O₂
• 分子量: 236.262
• InChiKey: MHRFRDWLNRHXMY-SSDOTTSWSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1
• 重原子数：
  16
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.9
• 拓扑面积：
  55.6
• 氢给体数：
  1
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  (2R)-2-(氨基甲基)-4,4-二氟吡咯烷-1-羧酸叔丁酯 、 3-amino-6-[3-methylimidazo[1,2-a]pyridin-6-yl]-5-(1,3-oxazol-2-yl)pyrazine-2-carboxylic acid 在 1-丙基磷酸酐 、 N,N-二异丙基乙胺 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 以88.95%的产率得到(R)-tert-butyl 2-((3-amino-6-(3-methylimidazo[1,2-a]pyridin-6-yl)-5-(oxazol-2-yl)pyrazine-2-carboxamido)methyl)-4,4-difluoropyrrolidine-1-carboxylate
  参考文献：
  名称：

  WO2020035052A5

  摘要：

  公开号：

  WO2020035052A5

文献信息

• PYRAZINE COMPOUNDS AND USES THEREOF
  申请人：Dizal (Jiangsu) Pharmaceutical Co., Ltd.

  公开号：US20210251989A1

  公开（公告）日：2021-08-19

  The present disclosure novel pyrazine compounds targeting adenosine receptors (especially A1 and A2, particularly A2a). The present disclosure also relates to pharmaceutical compositions comprising one or more of the compounds as an active ingredient, and use of the compounds in the treatment of adenosine receptor (AR) associated diseases, for example cancer such as NSCLC, RCC, prostate cancer, and breast cancer.
• [EN] PYRAZINE COMPOUNDS AND USES THEREOF<br/>[FR] COMPOSÉS DE PYRAZINE ET LEURS UTILISATIONS
  申请人：DIZAL JIANGSU PHARMACEUTICAL CO LTD

  公开号：WO2020035052A1

  公开（公告）日：2020-02-20

  The present disclosure novel pyrazine compounds targeting adenosine receptors (especially A1 and A2, particularly A2a). The present disclosure also relates to pharmaceutical compositions comprising one or more of the compounds as an active ingredient, and use of the compounds in the treatment of adenosine receptor (AR) associated diseases, for example cancer such as NSCLC, RCC, prostate cancer, and breast cancer.