(3S)-1-(3'-methoxy-4'-hydroxyphenyl)-7-(4''-hydroxyphenyl)-(6E)-6-hepten-3-ol | 1452487-92-1

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 二芳基庚烷
• 英文名称: (3S)-1-(3'-methoxy-4'-hydroxyphenyl)-7-(4''-hydroxyphenyl)-(6E)-6-hepten-3-ol
• 英文别名: 4-[(E,3S)-3-hydroxy-7-(4-hydroxyphenyl)hept-6-enyl]-2-methoxyphenol
• CAS: 1452487-92-1
• 化学式: C₂₀H₂₄O₄
• 分子量: 328.408
• InChiKey: RDXGNAHMAOEPKS-WVMJFEGXSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.5
• 重原子数：
  24
• 可旋转键数：
  8
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.3
• 拓扑面积：
  69.9
• 氢给体数：
  3
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  (3S)-1-(3'-methoxy-4'-hydroxyphenyl)-7-(4''-hydroxyphenyl)-(6E)-6-hepten-3-ol 在 吡啶 作用下， 以 甲醇 、 正己烷 为溶剂， 反应 27.0h， 生成 [(E,3S)-1-(3,4-dimethoxyphenyl)-7-(4-methoxyphenyl)hept-6-en-3-yl] (2S)-3,3,3-trifluoro-2-methoxy-2-phenylpropanoate
  参考文献：
  名称：

  Diarylheptanoids with inhibitory effects on melanogenesis from the rhizomes of Curcuma comosa in B16 melanoma cells

  摘要：

  The methanolic extract from the dried rhizomes of Curcuma comosa cultivated in Thailand was found to inhibit melanogenesis in theophylline-stimulated murine B16 melanoma 4A5 cells. From the methanolic extract, three new diarylheptanoids, diarylcomosols I-III, were isolated together with 12 known diarylheptanoids. Their chemical structures were elucidated on the basis of chemical and physicochemical evidence. The diarylheptanoids inhibited melanogenesis, and several structural requirements of the active constituents for the inhibition were clarified. In particular, (3R)-1,7-bis(4-hydroxyphenyl)-(6E)-6-hepten-3-ol exhibited stronger inhibitory effect [IC50 = 0.36 mu M] without inducing cytotoxicity. The biological effect was much stronger than that of a reference compound, arbutin [IC50 = 174 mu M]. We conclude that diarylheptanoid analogs are promising therapeutic agents for the treatment of skin disorders. (C) 2013 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2013.07.010